LUNG DISEASES

This study tests a drug called teniposide in people with a hard-to-treat type of lung cancer that has spread and has not responded to standard treatments. The cancer must have a specific gene change (c-Myc-driven). The goal is to see if the drug can shrink tumors and control the …

This study tests whether adding an inhaled antibiotic (amikacin liposome suspension) to standard treatment helps clear a rare lung infection caused by M. xenopi bacteria. About 190 adults with this infection will receive either standard care alone or standard care plus the inhale…

This study looks at whether monitoring the immune response to cytomegalovirus (CMV) can help prevent CMV disease in people who receive a lung transplant. About 100 adult lung transplant patients who have had CMV in the past will be followed. The goal is to use immune system testi…

This study is for people with non-small cell lung cancer who had surgery but still had cancer cells left behind. It tests whether adding two drugs (sacituzumab and zimberelimab) after surgery can help keep the cancer from returning. About 129 participants will be split into three…

This study tests a drug called belumosudil for people who develop a serious lung condition (bronchiolitis obliterans syndrome) after a stem cell transplant. The goal is to see if the drug can improve lung function or slow the disease. About 45 participants with new or early-stage…

This study tests a new inhaled drug, mosliciguat, added to an existing treatment (treprostinil) for people with high blood pressure in the lungs caused by scarring lung disease. About 20 adults will take part to see if the combination is safe and tolerable. The goal is to manage …

This study tests whether a blood test (ctDNA) can help doctors decide if adding chemotherapy to the immunotherapy drug cemiplimab improves survival in people with advanced non-small cell lung cancer. About 63 adults with stage IV or stage IIIB/C lung cancer that has not been trea…

This study explores whether electrical impedance tomography (EIT), a non-invasive imaging method, can monitor lung function as well as standard spirometry. Researchers will compare EIT readings with spirometry results in 400 adults, including those with lung diseases and healthy …

This study tests a new way to manage breathing during lung cancer surgery. The 'open lung' method adjusts air pressure based on each patient's lung stiffness, aiming to prevent low oxygen levels and lung damage. 120 adults having lung cancer surgery will be randomly assigned to t…

This study looks at whether a simple bedside lung ultrasound can spot early signs of lung trouble in women admitted to the intensive care unit for pregnancy complications or gynecologic cancer. Researchers will track different ultrasound patterns and see how they relate to patien…

This study collects blood and tissue samples from 100 adults who have had a lung transplant in the last 10 years. Researchers will use these samples to study biomarkers and how infections affect outcomes. The goal is to improve care for people with advanced lung disease, not to t…

This study looks at how hard children with muscle or lung problems have to work to breathe. Researchers will use a small tube to measure breathing effort in 550 kids at Necker Hospital. The goal is to better understand these conditions and improve care.

This study aims to develop a non-invasive test using cough samples to detect lung diseases like cancer, asthma, and COPD early. Researchers will collect cough, mouthwash, and lung fluid from 2000 adults to analyze DNA and protein markers. The goal is to create a simple, breath-ba…

This early-stage study tests a new tablet form of the experimental COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how well the body absorbs the new tablet compared to the original version, and whether taking it with food or as a drink changes absorption.…

This study aims to develop a standard method for using a new freezing catheter to take lung tissue samples and treat lung lesions. Researchers will test the technique on donated human lungs from 200 patients undergoing lung transplant surgery. The goal is to measure how well the …

This study will follow 4,000 adults aged 25-35 without severe lung disease for many years. Researchers will measure lung function and track changes over time to learn what keeps lungs healthy and how to spot early signs of chronic lung disease. Participants will not receive any t…

This study gathers lung sound recordings from 200 adults (with and without breathing conditions) using digital stethoscopes in real clinics. The goal is to train machine learning algorithms to automatically detect wheezes, crackles, and other abnormal sounds. No treatment is give…

This study gathers normal and abnormal lung sounds from 250 adults and children using a digital stethoscope. Doctors will record sounds like wheezes and crackles during routine checkups. The goal is to train an artificial intelligence program to automatically detect these sounds,…

This study is for people who have had a lung transplant. It uses advanced blood tests to try to predict if the new lung will start to fail. The goal is to catch problems early and improve long-term health for transplant recipients.

This study looks at 1000 healthy people aged 25 to 35 to understand how their body, environment, and overall lung health relate to lung structure and function. Participants will take simple breathing tests to measure air movement, lung size, and gas exchange. The goal is to learn…