Your cough could reveal hidden lung disease
NCT ID NCT05854563
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aims to develop a simple, non-invasive way to detect lung diseases like cancer, asthma, and COPD by analyzing DNA and proteins from cough samples. Researchers will collect cough specimens from 2000 adults, including smokers and non-smokers, and compare them to samples from standard lung procedures. The goal is to find early markers of disease without the need for invasive tests.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 2,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2023
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
All consenting subjects \>=21 y.o.with a clinical indication/imminent bronchoscopy.
- Ages
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21 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age: minimum age of 21 years * Gender: Male and Female adults * Ethnicity: All ethnic groups and races * Subjects undergoing bronchoscopy for diagnostic purposes or therapy * Subjects without a known diagnosis of lung cancer who are not scheduled for lung tissue collection procedures * Subjects with a known or suspected diagnosis of asthma or COPD and are scheduled for a visit at Montefiore Asthma or COPD Center and individual practices, and/or in-hospital with exacerbation Exclusion Criteria: * Bleeding diathesis or known coagulopathy precluding clinically indicated biopsy (e.g., INR\>1.3, PTTr\>1.3), thrombocytopenia \<50,000, uremia with serum creatinine \>3.0 * Unstable angina * Recent myocardial infarction (within 3 months), * Uncontrolled congestive heart failure or severe pulmonary hypertension (mean PAP\>75 mmHg)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Albert Einstein College of Medicine
RECRUITINGThe Bronx, New York, 10461, United States
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