LUNG DISEASES

This study tests an inhaled medicine called mosliciguat for people with high blood pressure in the lungs caused by scarring lung disease. About 135 adults will receive either the drug or a placebo for 16 weeks. The goal is to see if the drug improves blood flow in the lungs and w…

This study tests a new device called the Aventus Thrombectomy System to safely remove blood clots from the lungs in people with acute pulmonary embolism. About 130 adults aged 18 to 80 with recent clot symptoms will be treated. The goal is to see if the device improves heart func…

This study was designed to test a special tube called the Versus Catheter for dissolving blood clots in the lungs. The goal was to see how well the catheter cleared clots and how easy it was for doctors to use. The study was withdrawn before any participants were enrolled, so no …

This program gives adults with advanced or spreading ROS1-positive non-small cell lung cancer access to taletrectinib when they cannot use approved treatments or join ongoing studies. It is for patients who, in their doctor's opinion, might benefit from the drug. The goal is to p…

This study looks at the long-term safety of a drug called ralinepag for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug is …

This study looks at how well the drug osimertinib combined with chemotherapy works as the first treatment for people with advanced EGFR-mutant non-small cell lung cancer. It involves 532 adults with stage IIIB, IIIC, or IV disease who have not had prior therapy. The goal is to me…

This study tests whether a combination of fish oil (Lovaza) and curcumin (from turmeric root) can reduce the size of lung nodules in current and former smokers aged 55 and older. Nineteen participants took the supplements for 6 months to see if nodules shrank and if the treatment…

This study looks at whether a bronchodilator (a drug that opens airways) can reduce shortness of breath and improve exercise ability in adults with cystic fibrosis. About 20 participants will receive either the drug or a placebo and then switch, so each person acts as their own c…

This study gathers lung sounds from 750 adults, both healthy and with lung conditions, using digital stethoscopes. The goal is to create an artificial intelligence algorithm that can automatically identify abnormal sounds like wheezes or crackles. This tool could help doctors spo…

This study looks at how well the Ion Endoluminal System works in everyday medical practice for taking tissue samples from lung spots or nodules. About 1,300 adults who need a lung biopsy or lesion localization will be observed. The goal is to see how often the system correctly di…

This study uses special brain scans (PET) to track how metabolism in the brain changes over time in people with lung, gut, or hormone diseases. Researchers want to see if these brain changes can help predict serious outcomes like tumor recurrence or survival. About 200 participan…

This study looks at the genes of 600 people with cystic fibrosis to find out why some have more severe lung disease than others. It does not test any new treatment. Instead, it collects genetic information to help researchers understand the disease better. Participants must have …

This study looks at whether educating doctors in small and mid-sized city hospitals about standard guidelines helps improve testing and treatment for people with advanced non-small cell lung cancer. About 1000 patients will be observed to see if more get the right molecular tests…

This study planned to give low-dose CT scans to firefighters aged 35 and older to check for lung cancer and other lung diseases caused by job-related smoke and chemical exposure. It aimed to see if screening based on occupation, not just smoking history, could catch cancers earli…