Kratom extract effects under the microscope: new study recruits regular users
NCT ID NCT06640569
First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times
Summary
This study from Johns Hopkins University aims to understand how commercial kratom extract products affect mood, thinking, and physical signs like heart rate and pupil size in adults who use them regularly. Researchers will also study how the body processes these products. The goal is to gather basic information, not to treat any condition.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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2 people
The number who actually took part.
- Started
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Nov 2024
- Finished
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Jul 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
US adults who use kratom extract products on a regular basis
- Ages
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21 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 1\) \>21 years old; * 2\) Experienced kratom extract product consumer of one of the leading US brands listed in the study protocol; * 3\) Reports a specific kratom extract product brand and specific dose amount (or range of typical dose amount) on the online screener; * 4\) English language proficient; * 5\) Willingness to provide requested samples of the kratom extract product currently being taken. Exclusion Criteria: * 1\) Reports any acute adverse or unexpected or otherwise sudden health event related to their typical kratom product dose that occurred within 30 days of screening; * 2\) Having ever sought medical attention for an acute adverse health event as a result of taking any kratom product; * 3\) Cannot or will not provide their kratom extract product samples in the form of an unopened package that is clearly labeled with at least the product and vendor name; * 4)The kratom extract product used by the participant has any semi-synthetic or fully synthetic ingredient listed or is known by the study team to have such an ingredient; * 5\) Currently breastfeeding or pregnant; * 6\) history or current diagnosis of psychotic disorder; * 7\) current untreated bipolar disorder; 8) current untreated major depressive disorder; * 8\) Current physical dependence on alcohol, benzodiazepines, or opioids (self-reported or otherwise evidenced) requiring medical intervention; * 9\) Reports use of fentanyl within the past month and/or has a fentanyl positive drug screen; * 10\) Discordance between self-reported substance use and drug screen results obtained during screening; * 11)Any physical, psychiatric, environmental, situational, or kratom product-related condition considered by the study team to increase risk or undue burden.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Johns Hopkins University
Baltimore, Maryland, 21224, United States
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Johns Hopkins University Behavioral Pharmacology Research Unit
Baltimore, Maryland, 21224, United States
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