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Scientists probe uterine fluid absorption to unlock fertility secrets

NCT ID NCT06847685

Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the uterus absorbs fluid during early pregnancy, which may affect fertility. Researchers will compare tissue samples from women with and without endometriosis or infertility. The goal is to understand the role of certain proteins in this process. No treatment is given; this is an observational study to gather knowledge.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Feb 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Women between the ages of 18-45 with or without endometriosis.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Subject must be a healthy woman between the ages of 18 and 45 years. 2. Women with diagnosed endometriosis or infertility (cases). 3. Women without a diagnosis of endometriosis or infertility (controls). 4. Subject must have regular menstrual cycles. 5. Subject must have a body mass index (BMI) between 18 and 40. 6. Subject must be or have been sexually active or have had a previous vaginal exam that used a speculum. 7. Subject must be able to understand and provide consent to procedures and use/disclosure of protected health information. 8. No history of Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, hepatitis B, and HIV. 9. For IVF study subjects, a minimum endometrial thickness of 7mm at the time of sample collection. Exclusion Criteria: 1. Pregnant women. 2. Study subjects with endometrial cancer. 3. Study subjects with a history of endometrial ablation. 4. Study subjects with undiagnosed uterine bleeding. 5. Women with reproductive diseases that affect the endometrium (such as fibroids or uterine polyps that distort endometrial cavity). 6. Study subjects with an intrauterine device (IUD).

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Conditions

The condition(s) this trial relates to.

endometriosis infertility disorder ovarian endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometrioma Endometriosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Johns Hopkins Hospital

    RECRUITING

    Baltimore, Maryland, 21287, United States

  • Rutgers University

    ACTIVE_NOT_RECRUITING

    Piscataway, New Jersey, 08854, United States

  • University of Georgia

    NOT_YET_RECRUITING

    Athens, Georgia, 30602, United States

More trials for these conditions

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