ENDOMETRIOSIS

This study tests if a newer surgical method called argon plasma coagulation (APC) is gentler on the ovaries than the standard cystectomy for treating ovarian endometriomas. Seventy-two women will be randomly assigned to one of the two procedures. The main goal is to see how each …

This study is testing a new robotic surgery system (Medtronic Hugo™) for hysterectomy, a surgery to remove the uterus. The goal is to see if the robot is safe and works well for treating conditions like fibroids, endometriosis, and certain cancers. About 70 adult women who need a…

This study looks at whether a medication called goserelin acetate, which temporarily stops menstruation (like a short-term menopause), can reduce fat buildup in the liver of women with endometriosis. About 62 women will receive the drug and have their liver fat and stiffness meas…

This study looks at whether having surgery to remove deep endometriosis from the bowel before IVF helps women with infertility get pregnant. About 120 women will be randomly assigned to either surgery plus IVF or IVF alone. The main goal is to see how many achieve a clinical preg…

This study looks at 350 women under 39 with advanced endometriosis (stage III-IV) who want to get pregnant. It compares two approaches: having surgery to remove endometriosis tissue before starting IVF, or going straight to IVF without surgery. The goal is to see which method lea…

This study tests whether a special PET scan (18F-FES PET/CT) can find endometriosis lesions more accurately than MRI. It involves 20 women with endometriosis—some with high pain, some with low or no pain. The scan measures estrogen receptor activity in lesions, which may help doc…

This study looks for signs of endometriosis in menstrual blood, which is easy to collect. Researchers will compare samples from 250 women with and without the condition, and also check if these signs change after surgery. The goal is to create a simple, non-invasive test to diagn…

This study is testing whether a special PET/MRI scan can accurately diagnose endometriosis. About 24 women with suspected endometriosis will get the scan before their planned surgery. The goal is to see if the scan can find endometriosis as well as or better than current methods,…

This small pilot study tests an internet-based therapy program for 10 people with endometriosis and chronic pain. The program teaches skills like mindfulness and acceptance to help reduce pain's impact on daily life. Participants work through online exercises and have phone suppo…

This study tests whether a single, short mindfulness session before endometriosis surgery can help reduce pain and the need for painkillers afterward. About 20 adults with endometriosis will either get the mindfulness session plus usual care, or just education plus usual care. Re…

This study tests whether giving a GnRH agonist injection before a frozen embryo transfer can improve pregnancy rates in women with endometriosis or adenomyosis. About 180 women aged 18-36 will be randomly assigned to receive either the hormone plus standard estrogen/progestin sup…

This study tests whether a multidisciplinary educational program, including workshops and regular nurse phone calls, can improve quality of life for women with endometriosis. About 260 women with confirmed endometriosis and chronic pelvic pain will be enrolled. The program is des…

This study tests a non-invasive device that stimulates the vagus nerve through the ear to reduce chronic pelvic pain in women with endometriosis. About 72 women will use the device at home and report if their pain improves. The goal is to see if this gentle stimulation offers a n…

This study tests whether using a dye to see the ureters during deep endometriosis surgery causes less pain afterward than the usual plastic stents. About 70 women aged 18–50 will take part across two UK hospitals. The goal is to see if this approach is practical and acceptable be…

This study is testing whether a low-fat plant-based diet can reduce pain and improve quality of life in women with endometriosis. 120 women aged 18-45 with confirmed endometriosis will be randomly assigned to either follow the diet for 12 weeks or stick with their usual eating ha…

This study tests whether a special 'good pain consultation' that includes pain education can help women with endometriosis feel more in control of their pain and improve their quality of life. About 110 women will either receive this consultation plus usual care, or usual care al…

This study tests a smartphone app called Lyv Endo designed to help women with endometriosis manage their condition. The goal is to see if using the app improves quality of life and reduces symptom severity. The study will enroll 304 women with confirmed endometriosis who have mod…

This study tests a new drug called vipoglanstat to see if it can reduce pelvic pain in women with endometriosis. About 190 women aged 18 to 44 with moderate to severe pain will take either the drug or a placebo for four months. The goal is to find a better treatment option for th…

This study follows 200 adult women who visit the emergency room for endometriosis or related symptoms. Researchers will track whether they receive proper treatments, specialist referrals, and imaging tests. The goal is to understand how emergency care impacts their long-term heal…

This study looks at whether a simple, noninvasive eye scan can detect signs of inflammation in women with endometriosis. Researchers will compare retinal images from 100 women—half with endometriosis and half without. The goal is to see if the eyes can provide a new way to monito…

This study looks at how the uterus absorbs fluid during early pregnancy, which may affect fertility. Researchers will compare tissue samples from women with and without endometriosis. The goal is to understand the role of certain proteins in this process. About 140 women aged 18-…

This study looks at how different fertility treatments (ovarian stimulation) affect blood clotting and clot breakdown in 300 women with infertility. Researchers want to see if certain protocols increase clotting risk, especially in women with endometriosis. The goal is to underst…

This study follows 15,000 women with endometriosis for up to 10 years to see how well different medical and surgical treatments work over time. Researchers track symptoms, quality of life, disease return, and pregnancy rates. The goal is to learn which treatments help most in the…

This study looks at how the immune system and inflammation might be involved in migraine. Researchers will compare levels of certain immune cells and inflammatory markers in 396 women with and without migraine, some of whom also have autoimmune diseases like multiple sclerosis or…

This study looks at whether surgery to remove deep endometriosis reduces a woman's egg supply. Researchers will measure a hormone called AMH before and 12 months after surgery in 100 women aged 18-39. The goal is to help doctors decide if women should consider freezing eggs befor…