ENDOMETRIOSIS

This study tests a less invasive surgery called laparoscopic sclerotherapy for ovarian cysts (endometriomas) caused by endometriosis. Instead of removing the whole cyst, doctors drain it and inject a solution to shrink it, which may better preserve a woman's egg supply. The study…

This study aims to develop a non-invasive diagnostic test for endometriosis, a painful condition affecting 1 in 10 women. Researchers will combine AI-enhanced ultrasound with blood, saliva, and tissue markers to detect the disease without surgery. 365 women aged 18-45 with suspec…

This observational study will follow 33 women with endometriosis who are taking relugolix combination therapy, a hormone-blocking drug, to see how well it reduces pelvic pain over 24 weeks in a real-world clinic. Researchers will measure pain changes using a standard pain scale a…

This study tests a new device called Hyivy that people with endometriosis can use at home. The device delivers gentle heat and stretches the vagina to help reduce chronic pelvic pain. Twenty adults with endometriosis and ongoing pelvic pain will use the device three times a week …

This study tests whether individual psychotherapy, group therapy focused on body image, or a mix of both can improve quality of life and reduce anxiety in women with endometriosis. Forty women will be randomly assigned to one of three therapy programs or a control group. The goal…

This study looks at whether following a Mediterranean diet can help women with endometriosis feel better and have less pain. Endometriosis is a chronic condition that causes inflammation and pain. The Mediterranean diet is known to fight inflammation. Researchers will ask 104 wom…

This study tests whether a 10-week virtual mindfulness program can improve quality of life for people with endometriosis-related chronic pelvic pain. Researchers will enroll 124 adults aged 18-50 with a diagnosis of endometriosis. Participants will attend online mindfulness works…

This study looks at whether magnetic stimulation using a device called the 'Tesla chair' can help reduce pain in women with endometriosis. Many women still have pain even after surgery or medication, and painkillers may stop working. The study will include 30 women and measure pa…

This study tests a new drug called HMI-115 to see if it can reduce pain in women with moderate to severe endometriosis. About 540 women aged 18-49 who have had surgery-confirmed endometriosis will receive either the drug or a placebo for 24 weeks, with a possible 28-week extensio…

This study tests a portable device called ActiTENS mini that uses mild electrical pulses to relieve chronic pelvic pain in women with endometriosis. About 208 women will try different stimulation strengths over 9 months to see if it reduces pain and improves quality of life. If i…

This study will compare two laparoscopic hysterectomy methods—total removal of the uterus versus partial removal (leaving the cervix)—in 500 women with benign conditions like fibroids, endometriosis, or abnormal bleeding. The main goal is to see which surgery leads to better qual…

This study will compare immune cells and gut bacteria in 40 women with and without endometriosis. Researchers hope to find biological markers that explain why the disease develops and worsens. The goal is to pave the way for new treatments that target the immune system rather tha…

This study will measure levels of certain environmental chemicals (called persistent organic pollutants) in the blood of 650 women with endometriosis. Researchers want to see if higher levels of these chemicals are linked to more severe disease. The study does not test any treatm…

This study looks at whether using ultrasound during surgery helps doctors better remove deep endometriosis from the bowel while keeping the bowel wall safe. About 57 women with bowel endometriosis will have their surgery guided by ultrasound. The goal is to see if this approach r…

This study aims to create a new lab model of human diaphragm muscle cells using tissue from women undergoing surgery for diaphragmatic endometriosis. Researchers will compare these cells to arm muscle cells to understand what makes the diaphragm unique. The goal is to provide a t…

This study aims to find out if women with deep endometriosis affecting the bowel have a higher chance of developing colorectal cancer. Researchers will compare gene activity in healthy and endometriosis-affected bowel tissue from 30 women who need surgery for their condition. The…

This study aims to understand why some women repeatedly fail to get pregnant or experience multiple miscarriages, even with fertility treatments. Researchers will compare uterine tissue and blood samples from 100 women with and without these conditions to look for differences in …

This study looks at two ways to measure endometriosis growths in the bowel before and during surgery. About 98 women will get both a standard vaginal ultrasound before surgery and a special ultrasound during their operation. The goal is to see if the during-surgery ultrasound giv…

This study looks at whether women with endometriosis who use AI tools like ChatGPT to prepare for their doctor visit have better or worse experiences. Researchers will compare satisfaction, treatment plan adherence, and communication quality between AI users and non-users. About …

This study looks at the immune system of 120 women aged 18-40 with chronic pelvic pain that hasn't improved with hormone treatment. Researchers will measure specific immune markers in the blood to see if there is a unique pattern linked to the pain. The goal is to better understa…

This study follows 100 women with deep endometriosis for 2 years to see if their lesions grow, shrink, or stay the same, and how this relates to symptoms and quality of life. Researchers will use regular ultrasounds and questionnaires to track changes. The goal is to learn whethe…

This study looks for biological markers in the fluid and tissue of the uterus and ovaries in women with moderate to severe endometriosis. The goal is to understand why some women with endometriosis have trouble getting pregnant and to find ways to personalize fertility care. Abou…

This study looks at why migraine and endometriosis often happen together in women. Researchers will follow 150 women over several menstrual cycles, tracking symptoms and taking blood samples. The goal is to find differences in a molecule called CGRP and hormone patterns that may …