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New study hopes to unlock fertility clues for women with endometriosis

NCT ID NCT07182643

Knowledge-focused Sponsor: Region Stockholm Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at fluid and tissue samples from the uterus and ovaries of women with moderate to severe endometriosis. Researchers want to find biological markers that explain why some women with endometriosis have trouble getting pregnant. The goal is to improve fertility treatments by understanding what happens in the body before an embryo implants.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could identify new ways to diagnose and treat infertility in women with endometriosis, leading to more personalized fertility care.
What could go wrong
This is an early exploratory study with no treatment being tested. It may not find clear biomarkers or lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2025

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

We are going to recruit 30 patients who undergo fertility preservation or fertility treatment before endometriosis surgery in the Reproductive Medicine Clinic in Karolinska University Hospital. Our patients are diagnosed with stage III/IV endometriosis according to rASRM staging by using ultrasound. The control group will consist of 60 healthy women without endometriosis signs in the ultrasound who present to our clinic as oocyte donors or for fertility treatment because of male factor or pregenetic testing for genetic diseases of the partner

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-40 years old * Diagnosed with moderate/severe endometriosis by ultrasound or laparoscopy (patient group) * Regular menstrual cycles 28-35 days * Speak English or Swedish and agree to participate in the study Exclusion Criteria: * Pregnancy or lactation in the last 3 months * Uterine anomalies * Pelvic inflammatory disease, endometritis, STD * Gynaecological cancers or other malignancies in the patient's history * Smoking (more than 10 cigarettes per day) or alcohol abuse * Immunosuppressing medicines * Major abdominal or pelvic surgery in the last 3 months * A specific genetic disease that is diagnosed before PGT in women undergoing treatment

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Conditions

The condition(s) this trial relates to.

endometriosis infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometriosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Karolinska Institute and Karolinska University Hospital Huddinge

    Stockholm, 14433, Sweden

More trials for these conditions

Other studies related to the condition(s) this trial covers.