Endometriosis

This trial tests whether screening women with endometriosis for pain complications before surgery, and offering specialized pain care to those who need it, improves their quality of life a year after the operation. Researchers will compare women who receive this extra pain manage…

This trial compares HHK001, an investigational version of leuprorelin acetate, to Enantone, an approved treatment for endometriosis. Both contain the same active ingredient, but HHK001 uses an updated formulation. The study will enroll 30 women aged 18-45 with endometriosis, who …

This trial investigates whether salsalate, an anti-inflammatory drug, can reduce the elevated risk of cardiovascular disease seen in women with endometriosis. Researchers will measure blood vessel function and markers of inflammation in 24 women with endometriosis compared to hea…

This study tests whether giving two injections of a long-acting hormone (GnRH-a) before standard hormone therapy can improve pregnancy rates in women with deep infiltrating endometriosis undergoing their first frozen embryo transfer. The hormone pretreatment aims to suppress endo…

This phase 3 trial tests whether taking Relugolix combination therapy (Rel-CT) right after endometriosis surgery leads to better quality of life and less chance of the disease coming back. About 110 women having laparoscopic or robotic surgery for endometriosis will be randomly a…

This study compares a new barbed suture (SYMMCORA) with a standard one (V-Loc) for closing the vaginal cuff after laparoscopic hysterectomy. The goal is to see if the new suture reduces stitching time without increasing complications. About 132 women having elective laparoscopic …

Stanford University is testing the da Vinci Xi robot for various surgeries in children aged 6-21. The study will enroll 250 participants to check if the robot is safe and works well. The goal is to see if robotic surgery can be a good option for kids needing procedures like gallb…

This study looks at whether surgically removing deep endometriosis from the bowel before IVF improves pregnancy rates compared to IVF alone. It includes 120 women with infertility and pain from deep endometriosis. Participants are randomly assigned to either have surgery then IVF…

This study compares three surgical treatments for endometriomas (ovarian cysts from endometriosis) in 332 women aged 18-43 who want to become pregnant. Participants are randomly assigned to cystectomy, plasma vaporization, or sclerotherapy. The main goal is to see which approach …

This study is testing whether a daily pill called Relugolix CT (Myfembree) can reduce pelvic pain, inflammation, and pain sensitivity in women with endometriosis. Researchers will measure changes in blood markers of inflammation and brain scans related to pain. The trial involves…

This study looks at whether giving a GnRH agonist before a frozen embryo transfer can help women with endometriosis or adenomyosis get pregnant. About 180 women aged 18 to 36 will be randomly assigned to receive either standard hormone support or standard support plus one or two …

This study looks at a treatment for large ovarian cysts caused by endometriosis (6 cm or bigger). The approach involves draining the cyst during a keyhole surgery and then using hormone therapy to lower the chance of the cyst coming back and to protect the ovaries. The goal is to…

This study tests whether giving patients a special nutritional drink (immunonutrition) before bladder removal surgery can reduce complications like infections. About 232 adults having open cystectomy for various bladder conditions will be randomly assigned to receive the drink or…

This study compares two surgical methods for treating ovarian endometriomas (cysts caused by endometriosis): standard cystectomy (removing the cyst wall) and argon plasma coagulation (using a gas-based tool to destroy the cyst lining). The goal is to see which method better prese…

This study tests if injecting alcohol into endometriosis-related ovarian cysts (sclerotherapy) can better preserve egg supply and reduce cyst return compared to standard surgical removal. Sixty women aged 18-40 with cysts at least 2 cm will be randomly assigned to one of the two …

This study compares two approaches for women under 39 with advanced endometriosis who want to get pregnant: having surgery to remove endometriosis lesions before IVF, or going straight to IVF. The goal is to see which leads to more live births within three years. The trial will e…

This study follows 140 patients who previously received High-Intensity Focused Ultrasound (HIFU) for rectal endometriosis. Researchers want to see if the treatment's benefits—like pain relief and better quality of life—hold up over the long term. Participants fill out online ques…

This phase 3 trial tests whether a plant-based supplement (Indinol Forto, made from indole-3-carbinol) works as well as a standard hormone drug (Visanne, dienogest) for reducing pelvic pain in endometriosis. About 290 women aged 18-45 with surgically confirmed endometriosis will …

Researchers at Semmelweis University are building and testing artificial intelligence algorithms that read standardized transvaginal ultrasound images. The study includes women aged 18 to 45 who have suspected endometriosis or adenomyosis, a confirmed uterine mass scheduled for s…

Endometriosis is a painful condition where tissue similar to the uterine lining grows outside the uterus, often causing pain and infertility. Currently, diagnosis requires invasive surgery. This study investigates whether measuring two proteins, SNCG and BCL6, in blood or menstru…

This study tests a new blood test called EndoCheck that uses artificial intelligence to detect endometriosis in women with chronic pelvic pain. Researchers aim to see if the test is accurate enough to replace or reduce the need for exploratory surgery. About 1,200 women aged 14 t…

This study is testing whether a special full-body PET/CT scan can spot endometriosis without needing surgery. Up to 30 women with suspected endometriosis will get two scans using different tracers that highlight bleeding and scarring. The scan results will be compared with findin…

This study follows 20,000 women who take a new saliva test (Endotest) to diagnose endometriosis. Researchers want to see how the test result—positive or negative—affects their quality of life, emotions, and care decisions. Participants fill out questionnaires and share medical da…

This study is testing a new, non-invasive lab test that uses menstrual blood to diagnose endometriosis. Currently, diagnosis requires surgery, which can take years to get. The study will enroll 200 women aged 14-49 to see how accurate the test is compared to standard methods.

This study aims to find markers in menstrual blood that can diagnose endometriosis, a painful condition affecting many women. Researchers will compare menstrual blood from 250 women with and without endometriosis, and also look at changes after surgery. If successful, this could …

This study is testing whether a special PET scan called 18F-FES PET/CT can find endometriosis lesions more accurately than standard MRI. The scan measures estrogen receptors in the lesions, which may help doctors understand pain levels and guide treatment. About 20 women with end…

This study is looking at whether a protein called L-PGDS can be used to diagnose adenomyosis, a condition where uterine tissue grows into the muscle wall, causing pain and heavy bleeding. Researchers will measure L-PGDS levels in vaginal swabs, blood, and urine from 60 women with…

This study tests whether a specific ultrasound measurement can reliably detect superficial endometriosis on the uterosacral ligaments. Researchers will compare ultrasound findings with laparoscopic surgery results in 64 women undergoing gynecological surgery. If a clear cutoff th…

This study tests a new blood test called HerResolve™ to see if it can accurately detect endometriosis in women aged 18 to 49 who have symptoms like pelvic pain or abnormal bleeding. About 100 participants will give a blood sample before their scheduled laparoscopy (a surgical pro…

This study tests whether ultrasound-guided alcohol sclerotherapy can reduce pelvic pain and improve quality of life in women aged 18-45 with ovarian endometriomas. Participants are randomly assigned to receive the procedure or no treatment (expectant management) and are followed …

This study tests a new drug called vipoglanstat to see if it can reduce pelvic pain in people with endometriosis. About 190 women aged 18 to 44 with moderate to severe pain will take either the drug or a placebo for four months. The goal is to find a better treatment option for t…

Researchers at Mount Sinai are testing whether a reinforcement learning system can deliver personalized daily exercise recommendations to people with chronic pelvic pain. The study enrolls 45 adults who receive alternating standard and AI-generated exercise advice over four two-w…

This study compares two types of radiation therapy—proton therapy and standard intensity-modulated radiation therapy (IMRT)—given after surgery for cervical or endometrial cancer. The goal is to see if proton therapy causes fewer bowel side effects. About 120 women will fill out …

This Phase 3 trial tests HMI-115, a monoclonal antibody, in 540 women with moderate to severe endometriosis pain. Participants receive either the drug or a placebo for 24 weeks, with a 28-week extension. The goal is to see if HMI-115 reduces menstrual and pelvic pain better than …

Endometriosis often causes long-lasting pelvic pain that can disrupt daily life. This trial tests whether specialized pelvic floor physical therapy, combined with a structured exercise program, can lower pain more than a placebo version of the therapy. Women aged 18 to 45 with co…

This trial tests whether a custom-formulated, high-CBD hemp product can reduce pain in women with endometriosis, adenomyosis, or chronic pelvic inflammatory disease. Over 7 days, participants receive either the CBD product or a placebo. Researchers will measure how the body proce…

This study tests whether up to 9 sessions of electroacupuncture can reduce pelvic pain in women with suspected endometriosis who are scheduled for diagnostic surgery. 38 women aged 18-45 with moderate to severe pain will be enrolled. The goal is to see if this treatment can impro…

This phase 2 trial tests a custom high-CBD sublingual product against a placebo in 30 women with endometriosis. Over 12 weeks, researchers will measure changes in pain and quality of life. The goal is to see if cannabinoids can help manage symptoms where few proven options exist.

This study tests whether a specialized kit helps women with endometriosis manage pain during sex. The kit includes a guidebook, a tracking app, a TENS device, lubricants, and supplements. One hundred women aged 18 to 45 with confirmed endometriosis and sexual pain will either use…

This study tests a 12-week digital program called Samphire Guided Care for people with menstrual or pelvic health conditions like PMS, endometriosis, or menopause. The program combines a wearable device that gently stimulates the brain, coaching, and symptom tracking to see if it…

This study tests whether injecting the local anesthetic bupivacaine into the small surgical cuts and the vaginal cuff at the end of a laparoscopic hysterectomy can lower postoperative pain. 120 women having the surgery for non-cancer reasons will be randomly assigned to receive t…

This study tests if whole-body cryotherapy (standing in a -120°C chamber for 3 minutes) can safely reduce pain and improve quality of life in people with endometriosis. Thirty participants with chronic pelvic pain will attend 5 sessions over 4 weeks. Researchers will measure pain…

This study tests whether a 12-week virtual yoga program can reduce pain in women with endometriosis. Researchers will enroll 30 women aged 18-45 who have moderate pain and a confirmed diagnosis. Participants will attend online yoga classes and report their pain levels using quest…

This study tests whether pulsed electromagnetic field (PEMF) therapy can reduce pain and improve quality of life in women with endometriosis. Sixty women aged 18–45 will receive either real PEMF or a sham device three times a week for 8 weeks. Researchers will measure pain, pelvi…

This study tests whether a physiotherapy program that combines gentle exercise with pain education can reduce pain and improve daily life for women with endometriosis. About 62 women will take part, with half receiving the combined program and half receiving pain education alone.…

This study tests a new surgical technique called intra-operative dual laparoscopy and neo-rectoscopy (IDLnR) for treating bowel endometriosis. Researchers will compare it to standard laparoscopic surgery in 192 women aged 18-55. The goal is to see if the new method leads to bette…

This study tests whether listening to an educational podcast can improve quality of life, reduce stigma, and increase satisfaction for people with chronic pelvic pain or endometriosis. One hundred participants will either receive standard care or standard care plus access to the …

This study is testing whether a low-FODMAP diet can reduce pain and improve quality of life in women with endometriosis who also have gut symptoms like bloating and nausea. Researchers will compare the diet to standard care in 150 women aged 18-45. The goal is to see if changing …

This study tests whether a special pain consultation and education session can help women with endometriosis feel more in control of their pain and improve their quality of life. About 110 women will either receive the new consultation plus usual care, or usual care alone. They w…

This study tests whether a whole food plant-based diet can reduce pain in women with endometriosis. 120 women aged 18-45 with moderate to severe pelvic pain will be randomly assigned to either follow the special diet or stay on their usual diet for 12 weeks. The goal is to see if…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can reduce pelvic pain in women with endometriosis. The trial will include 64 women who have moderate to severe pain and are waiting for surgery. Half will receive 40 HBOT sessions…

This study looks at whether combining pain neuroscience education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related distress in women with endometriosis. About 32 adult women diagnosed with endometriosis will take part. Researchers will tr…

This study tests whether a small electrical device (TENS) can reduce pelvic pain in women with endometriosis or adenomyosis. 92 women on stable hormone therapy will use the device for 45 minutes daily over 4 weeks, rating their pain on a scale. The goal is to see if the device lo…

This study tests whether a food supplement called Doliral can improve quality of life and reduce pelvic pain in women with endometriosis. About 60 women with confirmed endometriosis and ongoing pelvic pain will take either Doliral or a placebo for 12 weeks. Researchers will track…

This pilot study tests whether internet-based Acceptance and Commitment Therapy (ACT) can help people with endometriosis cope with chronic pain. Ten participants will receive online sessions focused on mindfulness, acceptance, and value-based behavior change, with phone support f…

This study compares robot-assisted hysterectomy to standard laparoscopic surgery for women with deep endometriosis and adenomyosis. The goal is to see which approach leads to fewer complications and better quality of life. 224 participants will be randomly assigned to one of the …

This study tests an 8-week group program called PEEPS for people with endometriosis-related chronic pelvic pain. Participants attend weekly sessions with others and get education and support, in addition to their usual care. The goal is to see if this approach reduces how much pa…

This study tests whether a series of workshops led by different health experts, plus regular nurse phone calls, can improve quality of life for women with endometriosis. About 260 women with confirmed endometriosis and chronic pelvic pain will take part. The program focuses on ed…

This study tests whether a wearable device called NettleEndo, which delivers mild electrical stimulation to the brain, can reduce chronic pelvic pain in women with endometriosis. About 120 women will use the device at home for 20 minutes a day, five days a week, for 12 weeks. Hal…

This pilot study tests whether a single, brief mindfulness session before endometriosis surgery can help women cope with pain and use fewer opioids afterward. Twenty adults with endometriosis will be split into two groups: one gets the mindfulness session plus usual care, the oth…

This study tests if a non-invasive device that stimulates a nerve in the ear can reduce chronic pelvic pain caused by endometriosis. The device is thought to lower inflammation and change brain chemicals that affect pain. Researchers will enroll 72 women with endometriosis to see…

This study compares a home pelvic floor physical therapy program to standard care for 30 women having endometriosis surgery (without hysterectomy). Participants will report their pain and quality of life over the recovery period. The goal is to see if a simple home program can ea…

This study looks at whether a special low-FODMAP diet and probiotics can reduce chronic pelvic pain in women who have both endometriosis and irritable bowel syndrome (IBS). Researchers will compare three groups: one getting the diet plus a placebo, one getting the diet plus probi…

This pilot study tests whether using a dye called indocyanine green to highlight the ureters during endometriosis surgery causes less pain and fewer side effects than the standard method of placing temporary plastic stents. The trial will recruit 70 women aged 18–50 who are sched…

Researchers are studying atypical endometriosis, a form of the condition whose cells look unusual under the microscope and may sometimes precede ovarian cancer. The study enrolls about 200 adults scheduled for endometriosis surgery or surgery for suspected ovarian or endometrial …

This study follows 200 adult women who visit the gynecological emergency department for endometriosis or related symptoms. Researchers want to see if emergency care leads to proper follow-up, like specialist visits or imaging. The goal is to understand how well the emergency syst…

This study looks at women who had surgery for deep endometriosis affecting the ureters, the tubes that carry urine from the kidneys to the bladder. The goal is to see how their kidney function and blood pressure fare years after the operation, and whether the type of surgery matt…

This study will compare patient satisfaction between telehealth (video or phone) and in-person follow-up visits after minimally invasive gynecologic surgery. About 100 women will be randomly assigned to one of the two follow-up methods. The goal is to see if virtual visits are as…

This study follows women aged 18 to 45 with endometriosis, along with healthy matched controls, for 24 months to see how the condition affects pain, cyst recurrence, and pregnancy outcomes. Participants receive their usual care, and researchers collect clinical data at regular in…

This study aims to understand the challenges women with endometriosis face when trying to access pelvic health physiotherapy in Quebec. Researchers will interview patients, survey physiotherapists, and hold group discussions with patients and healthcare providers. The goal is to …

This study looks at the immune system of 120 women aged 18-40 with chronic pelvic pain that hasn't improved with hormone treatment. Researchers will measure specific immune markers in the blood to see if there is a unique pattern linked to the pain. The goal is to better understa…

This study investigates how pelvic floor muscle strength, endurance, and relaxation ability are linked to chronic pelvic pain in women with endometriosis. Researchers will compare 50 women with endometriosis to 50 healthy women, measuring muscle function with a vaginal pressure d…

This study looks at how deeply argon beam coagulation (a tool that uses ionized gas to seal tissue) penetrates the ovary during laparoscopic surgery for ovarian endometriomas. Researchers will apply the technique to the cyst surface before removing it, then examine the tissue und…

This study looks at how surgery for severe deep endometriosis impacts a woman's egg supply, measured by a hormone called AMH. Researchers will follow 100 women aged 18 to 39 for 12 months after surgery. The goal is to see if the procedure lowers AMH levels, which could help guide…

This study investigates why endometriosis and migraine often occur together. Researchers will measure pain sensitivity and sex hormone levels in four groups: people with endometriosis, people with migraine, people with both conditions, and healthy controls. Participants complete …

This study investigates why endometriosis causes pelvic pain by measuring how the body processes heat, cold, and pressure. Researchers will also analyze hormone levels, immune markers, and genetic factors from blood, urine, saliva, and tissue samples. Participants are females age…

This study looks at tissue samples from 40 women with endometriosis to see how certain molecules behave in diseased tissue compared to healthy tissue. The goal is to better understand what causes endometriosis. No treatments are being tested—this is a fact-finding study using sto…

This study compares how laparoscopic removal of ovarian cysts affects ovarian reserve—a key measure of fertility potential—in women with endometriotic cysts versus non-endometriotic cysts. Researchers will measure levels of anti-Müllerian hormone (AMH) before and three months aft…

ENDO1000 is a UK-wide research project involving 1000 people with endometriosis. Participants will use a mobile app to track symptoms like pain, fatigue, and sleep, and some will provide blood, urine, and other samples at home. The goal is to collect detailed data over time to he…

This study is looking at 135 women with and without endometriosis to understand how hormones, environmental chemicals, and vaginal bacteria differ between the groups. Researchers hope to find patterns that could lead to faster diagnosis and better treatments. Participants give bl…

This study looks at whether women with Ehlers-Danlos syndrome (EDS) experience more severe period pain than those without the condition. Researchers will compare pain levels and other gynecological issues in 156 women using an online questionnaire. The goal is to better understan…

This study looks at how pesticides and the bacteria in your gut and genital tract might be linked to endometriosis and infertility. Researchers will compare 160 women with and without endometriosis to find patterns in their DNA and bacteria. The goal is to better understand the d…

This study listens to 150 people with endometriosis across Europe to understand how they manage their condition every day. Researchers want to learn what makes people feel empowered or abandoned by their support systems. Participants will share their stories through diaries, inte…

This study aims to understand how stem cells from menstrual blood and the immune system behave differently in women with endometriosis compared to healthy women. Researchers will collect menstrual blood, tissue samples, and questionnaires from 40 women aged 18-45. No treatments a…

This study looks at whether Ryeqo, a newer hormone treatment for uterine fibroids and endometriosis, increases the risk of dangerous blood clots. Researchers will take blood samples from 30 women before they start Ryeqo and again after 3 months of treatment. The goal is to measur…

This study will use pelvic ultrasound to check for endometriosis and adenomyosis in 400 women aged 29–37 who are freezing their eggs for non-medical reasons. Researchers will compare imaging findings with symptoms, anxiety, depression, and quality of life. The goal is to understa…

This study looks at whether using ultrasound during surgery can help doctors more accurately find and treat deep endometriosis in the bowel. About 200 women with suspected bowel endometriosis will have an ultrasound probe placed in the vagina or rectum during their operation. The…

This study looks at how the uterus absorbs fluid during early pregnancy, which may affect fertility. Researchers will compare tissue samples from women with and without endometriosis or infertility. The goal is to understand the role of certain proteins in this process. No treatm…

This study looks at whether MRI scans can help doctors predict which women with endometriosis will benefit from the drug dienogest. Researchers will follow 48 women aged 19-45 who are starting dienogest for the first time. By comparing MRI images before treatment with changes in …

This study follows 650 women with endometriosis who want to have children after diagnosis. Researchers compare pregnancy rates and the need for fertility treatments between those who had surgery and those who took medication. The goal is to understand which approach leads to bett…

This study aims to create a complex lab-grown model of endometrial tissue using biopsies from women with and without endometriosis. Researchers will test how different hormone treatments affect the tissue, with the goal of predicting individual responses. The study involves 90 wo…

This study tests whether a new smartphone app called elleFA can help women with endometriosis track their symptoms and communicate better with their doctors. Twenty pre-menopausal women aged 18 and older will use the app for 6 months, completing monthly surveys and optional daily…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study from the University of Oxford is looking at whether brain scans can predict which women with severe endometriosis will have less pain after surgery. Researchers will scan the brains of 100 women before their operation and then check their pain levels a year later. The …

This study looks at how well pelvic organs move in women with endometriosis using dynamic MRI. Researchers want to see if measuring this movement can help diagnose the disease better and explain why some treatments don't work. About 52 women with suspected endometriosis will take…

This study looks at how different ovarian stimulation protocols affect blood clotting in 300 infertile women, including those with endometriosis. Researchers will measure clot formation and breakdown before and after treatment. The goal is to understand which protocols may be saf…

This study is building a national registry to collect data on people with parietal endometriosis, a condition where endometriosis tissue grows in the abdominal wall. Researchers will track those treated with either surgery or a less invasive technique called cryoablation (freezin…

This study looks at whether a simple, non-invasive eye scan can detect signs of inflammation in women with endometriosis. Researchers will compare retinal images from 100 women—half with endometriosis and half without—to see if the eyes can reveal information about this condition…

This study follows 15,000 women with endometriosis for up to 10 years to see how well different medical and surgical treatments work. Researchers will track symptoms, quality of life, disease return, and pregnancy rates. The goal is to better understand the long-term outcomes of …

This study is looking at 60 women who are getting a hormone-releasing IUD (LNG-IUD) to see if the timing of insertion during their menstrual cycle affects whether they develop ovarian cysts. Researchers will use ultrasound to check for cysts at 0, 3, 6, and 12 months after insert…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study follows 5,300 women aged 18-42 with endometriosis or adenomyosis to see if these conditions get worse over time. Researchers track pain, bleeding, fertility, and use imaging to monitor changes. They also explore immune system and gut bacteria links. No new treatment is…

This study looks at whether chlordecone, a pesticide still present in the environment in Guadeloupe, is linked to fertility problems in women. Researchers will measure a key fertility hormone (AMH) and count egg follicles in 634 women seeking fertility treatment. The goal is to u…

This study tests a surgical tool called CUSA Clarity that uses ultrasound to selectively remove endometriosis cyst lining while leaving healthy ovary tissue intact. Researchers will examine cyst wall samples from 10 women to see if the tool can spare ovarian tissue, which may hel…

This observational study is recruiting 530 women to better understand endometriosis and adenomyosis. Researchers will analyze genetic, epigenetic, and imaging data, using artificial intelligence to develop better diagnostic tools. The goal is to enable earlier detection and more …

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…