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Brain scans may predict surgery success for endometriosis pain

NCT ID NCT07313345

Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study from the University of Oxford is looking at whether brain scans can predict which women with severe endometriosis will have less pain after surgery. Researchers will scan the brains of 100 women before their operation and then check their pain levels a year later. The goal is to find a way to avoid surgery in women who are unlikely to benefit.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors identify which patients are most likely to benefit from surgery for severe endometriosis, avoiding unnecessary procedures.
What could go wrong
This is a small observational study, not a treatment trial. It may not find a reliable way to predict pain outcomes, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients on the waiting list for surgery for severe endometriosis at the Oxford University Hospitals NHS Trust

Ages

18 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * willing and able to give informed consent * aged between 18 and 50 years of age * female or born female * diagnosed with stage III or IV endometriosis by scan (MRI or USS) or previous surgery * surgical treatment of severe endometriosis planned (surgical procedure at discretion of operating surgeon) * reports pelvic pain of ≥4/10 (measured using a 0 - 10 numerical rating scale asking about the participant's worst pelvic pain associated with their endometriosis) * reasonably fluent in English * in the Investigator's opinion, is able and willing to comply with all study requirements * willing to allow his or her General Practitioner and consultant to be notified of participation in the study Exclusion Criteria: * pregnant, lactating or planning pregnancy during the course of the study * contraindication to MRI

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Conditions

The condition(s) this trial relates to.

endometriosis Pelvic Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometriosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Oxford University Hospitals Foundation Trust

    RECRUITING

    Oxford, Oxfordshire, OX3 9DU, United Kingdom

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