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Surgery before IVF may boost pregnancy odds in deep endometriosis

NCT ID NCT02948972

Disease control Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether surgically removing deep endometriosis from the bowel before IVF improves pregnancy rates compared to IVF alone. It includes 120 women with infertility and pain from deep endometriosis. Participants are randomly assigned to either have surgery then IVF, or IVF without surgery. The main goal is to see who gets a clinical pregnancy after two IVF cycles.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
complete surgery of colorectal deep infiltrating endometriosis
What this could lead to
If it works, this could show that surgery before IVF increases the chance of pregnancy for women with deep endometriosis and infertility.
What could go wrong
This is a relatively small trial (120 people) and surgery carries risks like infection or bowel injury. The benefit over IVF alone is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2016

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 38 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Primary and secondary infertility * Indication for IVF * Persistent pain related to endometriosis with analgesic medical treatment failure * Persistent pain including at least one of the following digestive symptoms related to endometriosis: Dyschesia / Sub-occlusive syndrome / Rectal bleeding / Painful defecation * Colorectal deep infiltrating endometriosis : Whatever lesion size / With at least rectal serosal involvement / Confirmed by MRI and 1 different investigation: vaginal ultrasound echography or coloscopic CT scan or rectal endoscope ultrasound * Eligible for DIE surgery Exclusion Criteria: * Contraindication to pregnancy or to IVF * Viral risk * Previous IVF cycle(s) * Previous colorectal surgery * Need of myomectomy during surgery * The use of oocytes donor

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Conditions

The condition(s) this trial relates to.

endometriosis endometriosis of intestine infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometriosis Infertility

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AP-HP, Hôpital Tenon

    RECRUITING

    Paris, France

  • CHU

    RECRUITING

    Clermont-Ferrand, France

  • CHU

    RECRUITING

    Poissy, France

  • CHU

    RECRUITING

    Rouen, France

  • Hôpital Jeanne de Flandres, CHRU

    RECRUITING

    Lille, France

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