INFERTILITY

This study is for women aged 18-40 who have trouble getting pregnant and may have chronic endometritis, a long-term inflammation of the uterus lining that often has no symptoms. Researchers will check how common this condition is, treat it with antibiotics, and then follow partic…

This study tests whether atosiban, a drug that relaxes the uterus, can improve live birth rates in women who have had previous embryo implantation failures and abnormal uterine contractions. About 792 women aged 20-40 will receive either atosiban or a placebo before a single embr…

This study tests whether using special devices to keep embryos at a stable temperature and control the transfer process can improve pregnancy rates in IVF. About 160 people will be randomly assigned to standard transfer or transfer with one or both devices. The goal is to see if …

This study tests whether taking letrozole for 10 days instead of the usual 5 days helps more women with PCOS ovulate and get pregnant. About 84 women aged 18-40 will be randomly assigned to one of two groups. The main goal is to see if the longer treatment leads to more ovulation…

This study tests a new combination of fertility hormones (follitropin alfa and lutropin alfa) against a standard treatment (hMG) in Japanese women with low LH and FSH who are undergoing IVF. The goal is to see if the new drug helps produce more eggs for retrieval. About 333 women…

This study compares two different daily doses (600 mg vs 800 mg) of vaginal progesterone in women undergoing a frozen embryo transfer. The goal is to see if the lower dose works just as well as the higher dose for supporting pregnancy. About 1,020 women aged 18-50 will take part.…

This study compares a generic version of the drug cetrorelix to the original brand-name drug for women undergoing IVF. The goal is to see if the generic works just as well at helping women get pregnant and have a baby. About 1,338 women will take part, and the main measure of suc…

This study looks at whether having surgery to remove deep endometriosis in the bowel before IVF helps women with infertility get pregnant. About 120 women will be randomly assigned to either surgery plus IVF or IVF alone. The main goal is to see how many achieve a clinical pregna…

This study tests whether a cheaper hormone (dydrogesterone) can replace the standard drug (GnRH antagonist) to prevent early ovulation in women with low ovarian reserve who are undergoing two rounds of egg retrieval in one cycle. About 120 participants will be randomly assigned t…

This study tests a fixed, low dose of a hormone drug (follitropin delta) in women undergoing fertility treatment called intrauterine insemination (IUI). The goal is to stimulate the ovaries to produce exactly two mature eggs, boosting the chance of pregnancy while lowering the ri…

This early-stage study is testing a combination of herbs (Melats P) to see if it can help women with Polycystic Ovary Syndrome (PCOS) have regular periods and improve fertility. The study will include 116 women aged 18-40 with PCOS and insulin resistance. Researchers will track m…

This study looks at whether levothyroxine, a thyroid hormone medication, can improve pregnancy rates in women with subclinical hypothyroidism (a mild underactive thyroid) who are undergoing IVF. Researchers will compare women who receive the drug to those who do not, tracking liv…

This study offers boys aged 0-17 the chance to freeze testicular tissue before starting treatments like chemotherapy or radiation that could cause infertility. The goal is to use this tissue later to help them have biological children. Researchers will track how many pregnancies …

This study tests whether testicular tissue frozen before puberty can be transplanted back into adult men who are infertile after cancer treatment. About 20 men who had gonadotoxic therapy as children and now have no sperm will receive their own stored tissue. Doctors will check i…

This study tests whether treating eggs and sperm before fertilization can help people who have had complete failure with standard IVF or a previous ICSI cycle. Researchers will measure fertilization rates and embryo development. The goal is to improve the chance of pregnancy for …

This study tests a new AI-assisted platform called IntelliWell that can identify rare sperm cells in testicular tissue samples from men with non-obstructive azoospermia (no sperm in ejaculate). Instead of discarding tissue that appears sperm-free under standard analysis, the plat…

This study tests whether a newer sedative, remimazolam, combined with alfentanil, can lower the risk of low oxygen levels (hypoxia) during egg retrieval for IVF, compared to the standard propofol-alfentanil combo. About 400 women aged 18-50 will take part. The goal is to make the…

This study tests whether adding a hormone called LH to standard fertility drugs improves egg quality and pregnancy rates in women aged 35-40 who had a low number of eggs in a previous IVF cycle. Participants will receive either the standard treatment or the standard plus LH. The …

This study looks at whether warming the dye used in a standard fertility test (HSG) can reduce pain and prevent false signs of blocked fallopian tubes. About 240 women aged 18-45 will be randomly assigned to receive either warm or room-temperature dye. The goal is to make the tes…

This study tests whether pentoxyfilline, a drug that improves blood flow, can thicken the uterine lining and increase pregnancy rates in women with unexplained infertility who are using frozen embryos. About 100 women will take the drug before their embryo transfer. The main goal…

This study tests whether inhaling lavender essential oil for four weeks can improve mental health in women waiting for IVF treatment. 120 participants will be split into three groups: one using real lavender oil, one using a placebo scent, and one receiving no treatment. The goal…

This study tests whether taking semaglutide (a weight-loss medication) for 12 weeks before starting IVF can improve the quality of embryos in overweight or obese women. About 62 women aged 38 or younger with a BMI between 27 and 40 will be randomly assigned to receive semaglutide…

This study looks at two forms of vaginal progesterone (soft capsules vs. pessaries) used in frozen embryo transfer. It aims to see which one women find more satisfying, convenient, and tolerable. About 400 women undergoing treatment will report their experiences and have pregnanc…

This study compares two types of liquid used to transfer embryos into the womb during IVF. One liquid has a high amount of hyaluronic acid (a natural sticky substance), and the other has a low amount. The goal is to see if the stickier liquid helps more women have a live birth. A…

This study tests whether adding growth hormone and DHEA (a natural hormone) before IVF can increase the number of mature eggs in women with poor ovarian reserve. About 165 women will take one of these treatments for several weeks before their IVF cycle. The goal is to see which a…

This study looks at how infertility and fertility treatments impact women's sexual function and behavior. About 500 women under 45 with infertility will fill out an anonymous questionnaire about their sexual experiences. The goal is to help doctors better support the sexual healt…

This study looks at whether low levels of a protein called mannose-binding lectin (MBL) in the blood are linked to repeated pregnancy loss or failed embryo transfers. Researchers will measure MBL levels in 500 women who have had three or more pregnancy losses or failed IVF attemp…

This study looks at whether blood-thinning drugs (anticoagulants) used in routine care can improve the womb lining and pregnancy rates in women with infertility. About 300 women aged 20-45 will be observed using special ultrasound scans. The study does not assign treatments—it si…

This study looks at whether the amount of a hormone called AMH in the fluid around a woman's egg can tell us if the resulting embryo has the right number of chromosomes. Researchers will collect fluid from the first egg follicle of each ovary during egg retrieval for IVF. They wi…

This study is testing a new automated system called AURA that can prepare sperm, find eggs, fertilize them, and freeze embryos for IVF. About 150 people will have their eggs and sperm processed by the robot, while a few eggs are handled the usual way for comparison. The goal is t…

This study tests a patient navigator program for 40 underserved people with infertility at Boston Medical Center. The navigator helps with insurance, appointments, and testing to speed up care. Researchers will compare how fast these patients get treatment versus similar patients…

This study looks at how searching the internet for health information affects stress and emotional well-being in women undergoing infertility treatment. Researchers will survey 201 women about their online search habits, stress levels, and emotional health. The goal is to underst…

This study looks at how the uterus's natural wave-like contractions (called peristalsis) affect pregnancy success in frozen embryo transfer. Researchers will track 356 women aged 18-42 to see if different hormone preparation methods change these contractions and impact implantati…

This study will follow about 2,500 Chinese women who are prescribed REKOVELLE for the first time during IVF or ICSI procedures. Researchers will observe how the drug is used in everyday practice and track key outcomes like live birth rates and side effects. The goal is to gather …

This study collects and stores ovarian tissue from females aged 4 to 35 who choose to freeze it before cancer treatment. Researchers will use a small portion of the tissue to learn how ovaries work and how they are affected by treatment. Participants also fill out yearly surveys …

This study tests whether a new automated machine can freeze human eggs and embryos as well as trained lab staff do by hand. About 125 people having IVF will donate extra eggs or embryos that would otherwise be thrown away. The machine's freezing success will be compared to the st…

This study follows 900 couples in Paris who tried preimplantation genetic diagnosis (PGD) during IVF but did not have a baby from it. Researchers want to learn how many later had a healthy child through other means, and why some couples stop trying. The goal is to better support …

This study is testing whether an artificial intelligence tool can better predict IVF outcomes by analyzing ultrasound images of the ovaries. Researchers will enroll 4,000 people undergoing fertility treatments to see if the AI can accurately count egg-containing follicles and for…

This study tests whether artificial intelligence can analyze routine vaginal ultrasound images of the uterine lining to predict whether an embryo will implant during IVF. About 1,500 women aged 18–40 undergoing IVF will participate, with no extra visits or procedures beyond stand…

This study looks at whether doing intrauterine insemination (IUI) 42 hours after a hormone shot (hCG) leads to more live births than the usual 36-hour wait. About 692 women with infertility will be randomly assigned to one of the two timing groups. The goal is to see if a slightl…

This study aims to find genetic causes of inherited reproductive disorders, such as early or delayed puberty and infertility. Researchers will collect blood samples, medical histories, and smell tests from 850 participants with these conditions and their family members. No treatm…

This study looks at how pesticides and the bacteria in the gut and reproductive tract might affect infertility in women with endometriosis. Researchers will compare 160 women with and without endometriosis to find patterns in DNA damage and bacterial signatures. The goal is to be…

This study looks at whether collecting sperm after just one hour of abstinence (instead of the usual 2-5 days) results in embryos with normal chromosomes during IVF. About 187 couples with infertility will each provide sperm after both short and standard abstinence, and the embry…

This study compares an AI system to doctors for deciding the optimal day to trigger ovulation in IVF. About 644 women undergoing ovarian stimulation will be randomly assigned to AI-guided or doctor-led monitoring. The goal is to see if the AI can achieve similar results in the nu…

This study aims to measure tiny, short-lived molecules called free radicals in individual sperm cells using a new diamond-based sensor. Researchers want to see if these molecules, along with gut bacteria and lifestyle factors, affect male fertility. The study involves 80 men visi…

This study looks at how the bacteria and natural chemicals in couples' bodies might influence the success of IVF treatment. Researchers will collect samples from 1000 couples to see if these factors are linked to pregnancy, miscarriage, or live birth. The goal is to better unders…