INFERTILITY

This study tests two treatments—oral isotretinoin (an acne medication) and hCG injections—to see if they can help men with low or no sperm count produce moving sperm. About 100 men aged 19 to 50 will receive one of the treatments for three months. The goal is to find new options …

This study tests whether adding a substance called cpFT to the liquid used to grow eggs and embryos can improve the chance of a live birth after a common fertility treatment called ICSI. The trial involves 366 couples where the woman is under 37 years old. Researchers will compar…

This study tests a new device called SwimCount Harvester that prepares sperm for IVF. It compares the device to standard methods in 1,600 couples undergoing IVF with genetic testing. The goal is to see if the device leads to more usable embryos and more normal embryos. The study …

This study tests whether injecting platelet-rich plasma (PRP) into the lining of the womb or infusing it into the womb works better for women who have had repeated failed embryo transfers. 180 women aged 18-40 with a history of at least two failed transfers will be randomly assig…

This study tests whether a progesterone injection works as well as a vaginal gel for helping embryos implant and maintain early pregnancy after frozen embryo transfer. About 680 women aged 35 to 42 with infertility will receive either the injection or the gel, and researchers wil…

This study tests whether group preconception care, adapted from group prenatal care, can improve pregnancy and newborn outcomes for fertility patients. About 140 couples at Penn Fertility Care will be randomly assigned to either group virtual sessions or usual care. Researchers w…

This pilot study tests whether an internet-based stress management program called Stress Free Now can lower stress and increase pregnancy rates in women aged 18-34 who have been trying to conceive for 6-12 months. Forty women will be randomly assigned to the program or a waitlist…

This study looks at how obesity may cause fertility problems by disrupting hormones and metabolism. Researchers will measure hormone levels and insulin response in 84 women with a healthy weight. The goal is to understand the link between obesity and infertility to guide future t…

This study was designed to measure how a hormone called GnRH is processed by the body when given through a wearable pump (OmniPod) in healthy women aged 18-40. The goal was to understand the drug's levels in the blood, which could help treat certain types of infertility. However,…

This study tests whether a program that sends helpful text messages and educational videos can help people complete their fertility testing more quickly. About 160 new patients at a fertility clinic will be randomly assigned to either receive the program or standard care. The goa…

This study looks at how well the fertility drug REKOVELLE works for ovarian stimulation in Asian women undergoing their first IVF or ICSI cycle. Researchers will track live birth rates and how the drug is used in everyday medical practice. The study involves 1,500 women across mu…

This study looks at whether an AI program called MAGENTA BLAST can accurately predict which 3-day-old embryos will grow into blastocysts by day 5. Researchers will review data from 80 women who had IVF to see if the AI's predictions match what actually happened. The goal is to gi…

This study looks at how the process of diagnosing infertility affects the sex lives of couples. Researchers will ask 80 heterosexual couples at a French hospital to fill out questionnaires about their sexual function and satisfaction. The goal is to understand if the diagnosis it…

This study looks at 2000 IVF patients to see if time-lapse videos of embryos can reveal clues about their genetic health. Researchers will compare the videos with genetic test results to find patterns. The goal is to learn more, not to provide a treatment.