INFERTILITY

This study tests a new way to prepare sperm for in vitro fertilization (IVF) to see if it is safe and leads to healthier embryos. About 202 couples will be randomly assigned to use either the new method or the standard one. The main goal is to check the number of normal embryos, …

This study looks at how safe and effective a fertility drug called corifollitropin alfa is for women aged 36 to 40 who are doing IVF. About 200 women will take the drug and be watched for side effects and pregnancy rates over one year. The goal is to see if this treatment helps o…

This study tests whether using two medications (a GnRH agonist and HCG) together to trigger egg maturation works better than HCG alone for women who respond poorly to fertility treatments. About 164 women with low ovarian reserve will be randomly assigned to one of the two trigge…

This study tests whether adding a traditional Chinese herbal formula (Xiehe DOR Bushen Tongzhi Formula) to standard ovulation induction therapy improves the chance of natural pregnancy in women aged 22-39 with diminished ovarian reserve (DOR). Participants will receive either the…

This study looks at whether surgically removing uterine fibroids (myomectomy) before in vitro fertilization (IVF) helps more women have a baby. It includes about 792 women under 40 with infertility and specific fibroids (4-6 cm, not distorting the uterine cavity). Half will have …

This study tests whether giving three doses of a hormone trigger (GnRH agonist) instead of the usual single dose before egg retrieval improves egg quality and pregnancy rates in women who produce many eggs during IVF. About 190 participants will be randomly assigned to one of the…

This study tests whether taking progesterone (a hormone) after intrauterine insemination (IUI) with letrozole can increase the chance of pregnancy. About 690 women with infertility will be randomly assigned to receive progesterone or standard care. The goal is to see if this simp…

This study explores whether a special blood product called pure platelet-rich plasma (P-PRP) can improve sperm movement. In the first phase, researchers will standardize how to prepare P-PRP. In the second phase, they will mix sperm samples with P-PRP to see if it increases motil…

This study tests whether a gamified healthy lifestyle training program helps women undergoing fertility treatments like IVF feel more confident and adopt healthier habits. About 105 women will be split into three groups: one gets the game-like program plus a booklet, another gets…

This study compares a new ultra-rapid embryo freezing method to the standard approach in 80 women receiving donor eggs. The goal is to see if the faster method is safe and effective by checking embryo survival after thawing and pregnancy rates. Participants must be using donor eg…

This study looks at 1,500 couples undergoing IVF to see if a computer can predict which embryos will successfully implant in the womb. Researchers will use time-lapse videos of embryo development and patient health data to train a machine learning algorithm. The goal is to make e…

This study looks at whether infertility or IVF treatments are linked to heart and blood vessel problems in women. Researchers will compare the health of women planning pregnancy naturally or after IVF, and those who already had a baby. The goal is to understand any connections an…

This study looks at whether women with deep endometriosis affecting the bowel have a higher chance of developing colorectal cancer. Researchers will compare gene activity in healthy and endometriosis-affected bowel tissue from 30 women having surgery. The goal is to improve risk …

This study looks at whether having a tattoo affects the success of fertility treatments like IVF. Researchers will compare pregnancy rates in women with and without tattoos after embryo transfer. The goal is to see if tattoo size, location, or ink color plays a role. About 328 wo…

This study aims to learn about the reproductive health experiences of female members and veterans of the Canadian Armed Forces. Researchers will survey over 1,000 women and interview about 30 individuals to understand issues like contraception, pregnancy, infertility, and pelvic …

This study looks at how different germs (like bacteria and viruses) spread between partners who are having trouble getting pregnant. Researchers will follow 200 couples for two years, collecting samples from the mouth and genitals every six months. The goal is to learn more about…

This study tests whether adding lab-grown ovarian support cells (made from stem cells) helps immature eggs mature in a dish. About 100 women undergoing IVF will donate extra eggs for research. The eggs will be split into two groups: one with the support cells and one without. The…

This study looks at whether tiny plastic particles in the body are linked to fertility problems. Researchers will measure microplastics in semen, eggs, and other samples from 1,000 men and women. The goal is to understand how these particles might affect pregnancy rates and help …

This study looks at a hormone called relaxin in women who become pregnant after embryo transfer. Researchers want to see if relaxin levels differ between fresh and frozen embryo transfers, which may help explain why frozen transfers have higher risks of problems like preeclampsia…