INFERTILITY

This study tested a new way to stimulate the ovaries for in vitro fertilization (IVF) that aims to keep estrogen levels more natural while still producing many eggs. The goal was to see if this method leads to more live births compared to the usual approach. The trial included 12…

This study tested whether giving a small daily dose of a hormone (human menopausal gonadotropin) after egg retrieval could improve the chance of having a baby for women undergoing IVF. 600 women aged 20-40 took part. The researchers measured live birth rates, pregnancy rates, and…

This study looked at whether a step-up dose of the drug letrozole helps women with PCOS who have trouble getting pregnant. 70 women took either a step-up or standard low dose for three menstrual cycles. The step-up group had more women with mature eggs and thicker uterine lining,…

This study looked at whether losing weight before in vitro fertilization (IVF) helps overweight and obese women have a live birth. Researchers followed 197 women aged 20-36 who were having their first IVF treatment. Some women followed a diet and exercise program for 3 months bef…

This study tested whether giving an extra hormone (FSH) along with the usual hCG trigger shot before egg retrieval improves egg quality and pregnancy rates in people undergoing IVF. Researchers compared the two-hormone combination to the standard single-hormone approach in 232 pa…

This study tested a high dose of the fertility drug follitropin delta combined with hCG in 118 women undergoing IVF. The goal was to see if it could increase the number of good-quality embryos. Participants were women aged 18 to 42 with regular cycles. The study was completed and…

This study tested a microfluidic chip that gently sorts sperm by swimming ability, compared to the standard spinning method, in 393 couples doing IVF for unexplained infertility. The goal was to see if the chip leads to more high-quality embryos on day 3. The approach aims to red…

This study tested whether a nursing program based on Levine's Conservation Model could improve the emotional well-being of women struggling with infertility. 80 women in Egypt were split into two groups: one received the special nursing care, and the other received standard care.…

This study tested a ready-to-use liquid called GM508 CultActive on 68 IVF patients who had low fertilization or poor embryo quality in previous cycles. The medium was used to treat eggs during fertilization to try to improve success. Results showed better fertilization rates and …

This study looked at whether taking melatonin supplements can improve egg quality and pregnancy rates in infertile women undergoing IVF. Researchers measured melatonin levels in the fluid around the eggs and tracked how many eggs matured, became embryos, and led to pregnancy. The…

This study looked at whether watching a video about IVF medications can improve quality of life and reduce anxiety in women going through IVF for the first time. 62 women participated, with some receiving the video education and others standard care. The goal was to see if this s…

This study tested whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) could help people dealing with the emotional stress of infertility. Nine adults with infertility completed 12 therapy sessions. Researchers measured changes in mood, stress, and how we…

This study looked at whether psychological support could help reduce anxiety in women about to undergo egg retrieval for IVF. 180 women were split into two groups: one received psychological help, the other did not. Their anxiety levels were measured using a questionnaire just be…

This study tested a supportive care program for couples undergoing IVF or other fertility treatments. 50 couples were randomly assigned to receive either the extra support or their usual care. The program aimed to reduce infertility-related stress and improve coping strategies. R…

This study looks at whether a new pain management protocol can reduce pain for people undergoing in vitro fertilization (IVF). Researchers compared pain scores from 206 patients who received the new protocol to data from an earlier study. The goal is to see if the new approach he…

This study looked at whether less invasive methods, like a vaginal swab or collecting fluid from the womb, can reliably measure the microbiome (the community of bacteria) in the reproductive tract. 57 women aged 18-50 provided samples using these gentler methods and the standard …

This study looked at people with low or no GnRH, a hormone that controls puberty and fertility. Researchers measured hormone levels, did imaging scans, and tested smell and hearing to find new patterns and genes linked to the condition. The goal was to better understand these rar…

This study looked at 87 women who had no eggs retrieved during their first IVF egg collection. Researchers tried giving them a second hormone trigger to see if eggs could then be collected. The goal was to understand how often this works and what factors might help predict succes…

This study looked at two methods of choosing sperm for in vitro fertilization (IVF) in 29 couples with infertility. One method used sperm that naturally bind to the egg's outer layer, while the other relied on the embryologist's manual selection. The goal was to see which method …

This study looked at how lifestyle factors like diet and health habits affect a couple's ability to conceive. Researchers followed 266 couples planning their first pregnancy, tracking how long it took to get pregnant and whether early pregnancy loss occurred. The goal was to bett…

This study looked at how in vitro fertilization (IVF) affects the quality of life of working women. Researchers followed 200 women starting their first IVF treatment at a hospital in France, using surveys to measure their emotional, physical, and social well-being over 18 months.…

This study looked at 110 women aged 35-40 with low ovarian reserve undergoing IVF. It compared a milder stimulation approach (using clomiphene citrate plus a low dose of follicle-stimulating hormone) to a more intense one (a higher dose of hormone alone). The goal was to see whic…

This study tested a new method for preparing sperm samples used in IVF (in vitro fertilization) to see if it helps embryos develop better. Researchers compared the new method to the standard way in 41 couples undergoing fertility treatment. The main goal was to see if more embryo…

This study looked at three different ways to perform a hysterosalpingography (HSG), an X-ray test that checks if a woman's fallopian tubes are open. The goal was to see which method caused less pain and gave doctors clearer images. Researchers reviewed records of 251 women with i…

This study looked at 148 women with infertility and an overactive immune system in the uterus. All received steroids before embryo transfer, but some had a sensitivity test first to see if the steroids would work. The goal was to see if testing improved live birth rates. The stud…

This study tested whether a simple mindfulness technique—paying close attention to changes in body sensations—could improve well-being for couples dealing with infertility. Researchers enrolled 70 people (infertile patients and their partners) who were about to start their first …

This study tested whether robots and artificial intelligence could automate key steps of IVF, such as preparing sperm and eggs, injecting sperm, and growing embryos. Researchers compared the automated process to the standard manual method using 42 patients' gametes. The goal was …

This study looked at 111 couples receiving donated eggs to see if the type of freezing solution used affected pregnancy rates. Researchers compared a solution made just for eggs versus a 'universal' one used for multiple stages. The goal was to see if switching to the universal s…

This completed early-stage study looked at how two fertility hormones, FSH and hCG, are processed by the body after daily injections in 28 healthy women. The goal was to understand the drug's absorption and buildup over time. The study did not test for pregnancy or infertility tr…

This study looked at 400 couples (some fertile, some infertile) to see how diet, lifestyle, and genetics impact the chance of getting pregnant. Researchers collected food questionnaires, blood tests, and body measurements. The goal was to understand nutritional factors, not to pr…

This study looked at 158 women having intrauterine insemination (IUI) to see if a hormone called progesterone, measured on the day of the procedure, is linked to getting pregnant. Researchers collected blood samples and tracked early pregnancies. The goal is to find a simple way …

This study tested if analyzing the fluid embryos grow in, using a technique called nuclear magnetic resonance (NMR), can quickly and cheaply identify which embryos have the right number of chromosomes. The goal is to improve success rates in assisted reproduction (IVF) by making …

This study looked at genes in the cells that surround a woman's eggs to see if they can help predict which embryos are most likely to lead to a pregnancy. Researchers studied 137 women undergoing IVF treatment. They measured gene activity in these cells and checked how it related…

This study followed 214 children born from two different fertility treatments—CAPA-IVM (a lab-based egg maturation technique) and conventional IVF—to see if their development, behavior, and growth differed at age 5. Parents completed questionnaires on communication, motor skills,…

This study tested whether a smartphone app that reminds patients to take their fertility medications helps them forget fewer doses. 387 women undergoing their first IVF treatment used either the app or standard care. Researchers compared missed doses, patient satisfaction, and th…

This study looked at how a single injection of Gonadotropins-IBSA, a fertility drug, is processed by the body. It involved 29 healthy women aged 18 to 45. The goal was to measure levels of follicle-stimulating hormone (FSH) and human chorionic gonadotrophin (hCG) in the blood and…

This study looked at whether transferring embryos in two separate steps (sequential double embryo transfer) leads to more live births than transferring them all at once. Researchers compared 778 couples undergoing IVF, matching similar patients in each group. The goal was to see …

This study compared two advanced embryo culture systems used in IVF to see which one helps embryos grow better. Researchers looked at how many embryos successfully implanted in the womb. The goal is to improve success rates for people struggling with infertility.

This study looked at whether testing the fluid around an embryo for genetic health can help doctors choose the best embryo to transfer during IVF. Over 1,100 couples took part, and the test was compared to the usual method of just looking at the embryo's shape. The goal was to se…