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New embryo test may boost IVF success without risky biopsies

NCT ID NCT04339166

Knowledge-focused Sponsor: Peking University Third Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether testing the fluid around embryos (non-invasive chromosome screening, or NICS) can help doctors choose the best embryo for IVF. Over 1,100 couples took part, with women aged 35-42. The goal was to see if adding NICS to standard visual checks leads to more live births and fewer miscarriages compared to visual checks alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,152 people

The number who actually took part.

Started

Apr 2020

Finished

Aug 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 42 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Infertile couples receiving IVF- ICSI procedure for assisted reproduction cycle 2. Female age: 35 - 42 years old 3. Women receiving controlled ovarian hyperstimulation treatment (including ultra-long protocol、long-protocol 、short protocol treatment with GnRH agonist and GnRH antagonist treatment protocol); and the number of oocytes ≥6; The female BMI is from 18 to 30kg/m2. 4. Culture embryos to blastocyst stage and all the blastocysts will be single cryopreserved. 5. Single frozen-thawed blastocyst Transferred for the first time 6. The number of blastocysts ≥2, morphology grade (above 4BC/4CB) 7. Written informed consent Exclusion Criteria: 1. One of couples with IVF or ICSI contraindications(such as poorly controlled type I or type II diabetes; liver disease or dysfunction; kidney disease or renal function abnormality; significant anemia; history of deep venous thrombosis, pulmonary embolus; history of cerebrovascular accident; uncontrolled hypertension or diagnosed heart disease; history of cervical, endometrial or breast cancer; undiagnosed vaginal bleeding.) 2. PGT cycles 3. Women who have pathologies or malformations that affect the pregnancy outcome: genital malformations, untreated hydrosalpinx, untreated uterine infections, intramural myomas \> 4cm , benign tumor of pelvic and abdominal cavity\> 4cm, intimal thickness\<8mm, pituitary tumors and malignant tumors of various tissues and organs during the patient's participation in the study 4. Untreated hyperprolactinemia, thyroid disease, adrenal disease 5. Women with endometrial polyps that were not treated before embryo transfer

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Conditions

The condition(s) this trial relates to.

chromosomal disorder Chromosome Aberrations infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chromosome abnormality Infertility

Contacts and locations

Locations

  • Hebei Maternity and Reproductive hospital

    Shijiazhuang, Hebei, China

  • Jinling Hospital,Nanjing University,School Medicine

    Nanjing, Jiangsu, China

  • Northwest women's and children's hospital

    Xi'an, China

  • Peking University Shenzhen Hospital

    Shenzhen, Guangdong, China

  • Peking University Third Hospital

    Beijing, China

  • Reproductive & Genetic Hospital of Citic-Xiangya

    Changsha, Hunan, China

  • Shengjing Hospital of China Medical University

    Shenyang, Liaoning, China

  • The First Affiliated Hospital,Sun Yat-sen University

    Guanzhou, Guangdong, China

  • The First Medical Center of Chinese People's Liberation Army General Hospital

    Beijing, China

  • The Second Affiliated Hospital of Wenzhou Medical University

    Wenzhou, Zhejiang, China

  • The Second Hospital of Hebei Medical University

    Shijiazhuang, Hebei, China

  • The Third Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, China

  • West China Second Hospital of Sichuan University

    Chengdu, Sichuan, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.