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Fertility drug choice may impact IUI success, large study suggests

NCT ID NCT03669276

Knowledge-focused Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study reviewed 1251 intrauterine insemination (IUI) cycles at one hospital to see if the type of fertility drug used or the cause of infertility affected pregnancy rates. Participants were women aged 20-44 with normal ovulation and their partners with adequate sperm. The researchers looked at clinical pregnancy and live-birth rates, aiming to identify factors that lead to better outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
gonadotropins (recombinant FSH, urinary FSH, or hMG)
What this could lead to
If successful, this could help doctors choose the best ovarian stimulation drug for each couple, potentially improving IUI success rates.
What could go wrong
This is a retrospective review, not a controlled trial, so results may not prove cause and effect. Findings may not apply to all fertility clinics or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,251 people

The number who actually took part.

Started

Aug 2014

Finished

Nov 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All couples attending our reproductive medical center to obtain homologous IUI program with COS between January 2007 and August 2014 ll couples had undergone a standard infertility evaluation, which included medical history, physical examination, and assessment of tubal patency by either hysterosalpingography or laparoscopy and hormonal analysis on cycle day 3.

Ages

20 to 44 years

Sex

Female participants only

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * women with a failure to conceive after, ≥12 months of unprotected and regular intercourse, * aged 20-44 years * with normal ovulation reserve (basal follicle- stimulating hormone (FSH) level \< 10 IU/l and estradiol (E2) level \< 30ng/mL); * theirpartnershadtohaveatotal motile sperm (TMS) count of\>1×106. Exclusion Criteria: * TMS ≤1×106; * sperm donation; * seropositivity for human immunodeficiency virus (HIV) for any couple member; * inseminations performed in a natural cycle or with clomiphene citrate (CC)

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Conditions

The condition(s) this trial relates to.

infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infertility

Contacts and locations

Locations

  • CHU Amiens-Picardie

    Amiens, 80054, France

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