New IVF method aims for more natural hormone levels to boost live births
NCT ID NCT02892942
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a new ovarian stimulation protocol for IVF that aims to keep estrogen levels more natural while still producing many eggs. 129 women with good IVF prognosis participated. The goal was to see if this approach leads to more live births compared to the standard method.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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129 people
The number who actually took part.
- Started
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Jan 2017
- Finished
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Feb 2019
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * IVF-ET candidates (excluding PGD and oocyte donor); * Body mass index from 18 to 30 kg/m2; * Non smokers; * Regular menstrual cycles (25-35 days); * Presence of both ovaries; * Antral follicle count (follicles measuring from 3 to 10 mm in diameter) ranging from 10 to 30 on cycle days 2 to 4; * Serum AMH levels ranging from 0.5 to 5.0 ng/mL; * Normal endometrium at ultrasound (US) and/or hysteroscopy; * Informed consent signed Exclusion Criteria: * Iatrogenic ovarian insufficiency (surgery, radiotherapy, chemotherapy); * Uterine abnormalities as demonstrated by pelvic US and/or hysteroscopy; * Usual contra-indications for COH (cancer risk, blood coagulation disorders, etc) * Renal insufficiency
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Antoine Béclère
Clamart, 92141, France
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