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Two-step embryo transfer may boost IVF success rates

NCT ID NCT07499453

Knowledge-focused Sponsor: Hopital Pierre Rouques - Les Bluets Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 778 couples undergoing IVF to see if transferring embryos in two steps (sequential double embryo transfer) leads to more live births than the standard one-step double transfer. Researchers compared pregnancy and miscarriage rates between the two methods. The goal was to find out if the sequential approach helps embryos implant better, especially in couples who had failed IVF before.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could point toward a better embryo transfer strategy for couples with previous IVF failures, potentially improving pregnancy chances.
What could go wrong
This is an observational study, not a randomized trial, so results may be influenced by other factors. The findings are not yet proven and need further confirmation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

778 people

The number who actually took part.

Started

Jan 2014

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of couples undergoing assisted reproductive technology (ART) at Pierre Rouquès - Les Bluets Hospital between January 2014 and December 2023. Female participants are biologically capable of becoming pregnant and have undergone either sequential double embryo transfer (SEQ-ET) or standard double embryo transfer (DET). The population includes women with a history of previous ART attempts, and does not exclude participants based on the presence or absence of a specific disease or condition.

Ages

20 to 42 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Infertile patients undergoing IVF with planned SEQ-ET or DET. * Age ≤ 42 years. Exclusion Criteria: * Age aged 43 years. * Cycles in which only a single embryo was ultimately transferred and cycles in which no embryo transfer occurred.

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Conditions

The condition(s) this trial relates to.

infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infertility

Contacts and locations

Locations

  • Hôpital Pierre Rouquès - Les Bluets.

    Paris, 75012, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.