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New IVF medium may help those with low fertilization rates

NCT ID NCT05722067

Disease control Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a ready-to-use calcium ionophore medium (GM508 CultActive) on eggs from 68 IVF patients who had low fertilization rates, poor embryo quality, or were over 40. The medium was applied shortly after sperm injection to try to improve fertilization and embryo development. The goal was to see if it could increase normal fertilization and high-quality blastocyst formation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
calcium ionophore (GM508 CultActive) medium
What this could lead to
If it works, this could help people with low fertilization rates or poor embryo quality have better success with IVF.
What could go wrong
This was a small, completed study with no phase designation, so results may not apply to all IVF patients. The treatment is a lab procedure, not a drug, and success depends on many factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

68 people

The number who actually took part.

Started

Jan 2023

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Low fertilization rate in previous IVF cycle (\<30%), or * Poor embryo developmental problems in previous IVF cycle, or * Diminished ovarian reserve (AMH\<1.2 or AFC\<5) and/or more than 40 y/o. Exclusion Criteria: * Without or just one oocyte picked up

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Conditions

The condition(s) this trial relates to.

infertility disorder long QT syndrome 3 ventricular fibrillation, paroxysmal familial, type 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Artificial oocyte activation Infertility IVF

Contacts and locations

Locations

  • Chang Gung Memorial Hospital

    Kaohsiung City, 123, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.