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Could a sleep hormone boost IVF success?

NCT ID NCT07343947

Symptom relief Sponsor: University of Sao Paulo General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking melatonin, a natural antioxidant, can improve egg quality and pregnancy rates in women undergoing IVF. Eighty infertile women received either melatonin or a placebo. Researchers measured melatonin levels in ovarian fluid and tracked egg maturation, embryo development, and pregnancy. The goal is to see if this simple supplement can help women struggling with infertility.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
melatonin
What this could lead to
If it works, this could point toward a simple, low-cost supplement to improve IVF success rates.
What could go wrong
This is a small, completed trial with 80 participants. Melatonin is not a standard fertility treatment, and results may not apply to all women or lead to higher pregnancy rates.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Jan 2022

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Infertile women aged 18-40 years * No previous infertility treatment * No previous hormonal treatment * No previous radio-chemotherapy treatment Exclusion Criteria: * Fertile women * Previous hormonal treatment * Previous radio-chemotherapy treatment

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Conditions

The condition(s) this trial relates to.

infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infertile women undergoing ivf or icsi Infertility Infertility (ivf patients)

Contacts and locations

Locations

  • Univertity of Sao Paulo, Clinics Hospital

    São Paulo, São Paulo, Brazil

More trials for these conditions

Other studies related to the condition(s) this trial covers.