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Can a sperm 'Quality Check' boost IVF success?

NCT ID NCT05017740

Disease control Sponsor: KK Women's and Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests whether a technique called PICSI, which selects sperm by their ability to bind to hyaluronic acid, can improve pregnancy rates and reduce miscarriage compared to standard ICSI. It involves couples who had poor fertilization in their first IVF cycle and are now trying again. The goal is to see if this sperm selection method makes a meaningful difference in achieving a healthy pregnancy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
PICSI (physiological intracytoplasmic sperm injection) - a procedure where sperm are selected by binding to hyaluronic acid before being injected into an egg during IVF.
What this could lead to
If PICSI proves better than standard ICSI, it could offer a simple way to improve pregnancy chances and lower miscarriage risk for couples who have struggled with poor fertilization in IVF.
What could go wrong
This is a small, early-stage trial, and previous evidence on PICSI is mixed. It may not show a clear benefit, and the procedure adds an extra step to IVF without guaranteed improvement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

47 people

The number who actually took part.

Started

Mar 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Couples with \<50% fertilisation in their first ICSI cycle, and scheduled for their second ICSI/PICSI cycle Exclusion Criteria: * Women with diminished ovarian reserves (AMH \<1.2ng/ml) or severe endometriosis (rAFS Stage III or IV) * Male partner with severe oligoasthenoteratozoospermia (Density \< 5 million, Total motility \< 40) or those require surgically retrieved sperm * Couples using donor gametes * Couples using frozen gametes * Couples undergoing split IVF-ICSI cycles * Couples where a freeze all approach has been done, either clinically indicated or secondary to patient choice

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Conditions

The condition(s) this trial relates to.

infertility disorder ventricular fibrillation, paroxysmal familial, type 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infertility IVF

Contacts and locations

Locations

  • KK Women's and Children's Hospital

    Singapore, 229899, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.