Can growth hormone or DHEA help women with low egg reserve get pregnant?
NCT ID NCT07323329
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving growth hormone or DHEA (a natural hormone) can improve egg production and pregnancy rates in women with poor ovarian reserve who are undergoing IVF. 165 women will receive one of these treatments or a placebo (folic acid only) for 1-3 months before their IVF cycle. The goal is to see which approach leads to more mature eggs and higher pregnancy rates.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Somatropin (growth hormone) and dehydroepiandrosterone (DHEA)
- What this could lead to
- If it works, this could offer a way to improve egg quantity and quality in women with poor ovarian reserve, potentially increasing their chances of pregnancy through IVF.
- What could go wrong
- This is a mid-stage trial with only 165 participants, so results may not apply to everyone. Hormone treatments can have side effects, and success is not guaranteed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
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About 165 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2025
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 35 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: At least two of the following three criteria had to be present after maximal stimulation: 1. Advanced maternal age (\>40 years) or any other risk factor for Poor Ovarian Response (POR). 2. ≤3 oocytes with a conventional stimulation protocol). 3. An abnormal ovarian reserve test \[i.e. antral follicle count (AFC) less than 5-7 follicles or anti-Müllerian hormone (AMH) below 0.5-1.1 ng/ml\]. Exclusion Criteria: 1. Any endocrine or metabolic disorder such as hyperprolactinemia, diabetes and thyroid dysfunction. 2. Any pelvic pathology such as hydrosalpinx, uterine anomaly. 3. Any male factor infertility such as Oligo-Astheno-Teratozoospermia (OAT) or azoospermia
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Beni-Suef University Hospital
RECRUITINGBanī Suwayf, Beni Suweif Governorate, 62521, Egypt
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