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Could a sticky solution help IVF embryos implant?

NCT ID NCT06165367

Disease control Sponsor: ART Fertility Clinics LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a substance called hyaluronan to the liquid used during embryo transfer can improve pregnancy rates in IVF. Researchers will compare live birth rates between women whose embryos are placed in a hyaluronan-rich medium versus a standard one. The trial involves 783 women using genetically normal frozen embryos.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hyaluronan-enriched medium (EmbryoGlue)
What this could lead to
If it works, this could improve the chance of a live birth after IVF by using a special medium during embryo transfer.
What could go wrong
This is a mid-stage trial, and previous studies have not shown clear benefits. The outcome depends on many factors, so success is not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 783 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 46 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All frozen embryo transfer (FET) cycles with euploid blastocysts biopsied and vitrified on Day 5 after PGT-A. * Rank of randomization based on embryo quality. * Only hormonal replacement theraphy (HRT) cycle regimen. * Women aged 18 years to 46 years. * Having at least 1 chromosomally normal vitrified blastocyst(s) on Day 5 available for transfer. * All sperm samples. * BMI between 18 and 35. Exclusion Criteria: * FET cycles with preimplantation genetic testing for monogenic disorders (PGT-M) and for structural rearrangements (PGT-SR). * FET cycles with mosaic / aneuploid blastocysts. * FET cycles with unknown outcome. * FET cycles with Day 6 or Day 7 biopsied blastocysts. * FET with patients' endometrium preparation with treatments other than HRT. * FET where PGT-A was performed for gender selection.

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Conditions

The condition(s) this trial relates to.

infertility disorder tremor, hereditary essential, 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blastocysts Clinical pregnancy rate FET Implantation rate Infertility Live birth rate

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • ART Fertility Clinics LLC

    RECRUITING

    Abu Dhabi, Abu Dhabi Emirate, 60202, United Arab Emirates

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