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Warm dye may ease pain during key fertility exam

NCT ID NCT07226310

Symptom relief Sponsor: University of Oklahoma Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tests whether warming the contrast dye used in a hysterosalpingogram (HSG) — a standard X-ray test for blocked fallopian tubes — can reduce pain and cramping during the procedure. About 240 women aged 18–45 will be randomly assigned to receive either warm or room-temperature dye. The goal is to see if warm dye leads to less discomfort and fewer false signs of blockage, which can happen when the tubes spasm from the cold liquid.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
warmed contrast dye
What this could lead to
If it works, this could make a common fertility test less painful and more accurate by reducing false blockages.
What could go wrong
This is a very early, small trial. Warming the dye may not meaningfully reduce pain or improve test results, and the effect may vary from person to person.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 240 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1\. Women ages 18-45 undergoing tubal assessment via HSG. Exclusion Criteria: 1. History of fibroids 2. History of pelvic inflammatory disease (PID or STD including gonorrhea, chlamydia, or trichomonas) 3. History of surgically diagnosed endometriosis or suspected endometriosis on ultrasound (indicated by visualization of likely endometrioma) 4. History of ectopic pregnancy or 3 or more biochemical pregnancies/pregnancy of unknown location 5. History of tubal or ovarian surgery 6. History of known Mullerian anomaly 7. History of pelvic surgery including appendectomy 8. Allergy to iodine-based contrast media 9. History of prior abnormal fallopian tubes on HSG 10. History of ultrasound with hydrosalpinx (unilateral or bilateral)

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Conditions

The condition(s) this trial relates to.

infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infertility

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Oklahoma Health Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

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