Could waiting just 6 more hours boost IUI success?

NCT ID NCT06804538

Disease control Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether performing intrauterine insemination (IUI) at 42 hours after a hormone trigger shot leads to more live births than the standard 36-hour timing. About 692 women with infertility will be randomly assigned to one of the two timing groups. The goal is to see if a small delay helps eggs and sperm meet at a better moment for fertilization.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: intrauterine insemination (IUI) procedure
What this could lead to: If successful, this could show that delaying insemination by a few hours boosts pregnancy and live birth rates for people undergoing IUI.
What could go wrong: This is a timing adjustment, not a new treatment, so the impact may be modest. The trial is still recruiting, and results may not apply to all infertility cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 692 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 43 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Single unmarried woman or heterosexual or homosexual couple in which the woman wishing to carry the pregnancy is aged 18 to 43 and the spouse is aged 18 to 60 at the time of inclusion * 2 permeable tubes for the woman receiving the insemination * Spouse's sperm (Number of inseminable sperm ≥ 1 million in prior survival migration test) or sperm donation * 1st or 2nd intrauterine insemination for this child project * Ovarian stimulation by gonadotropin with GnRH antagonist (introduced on a fixed day or according to the follicular size criterion of the center) * Luteal phase support with a progestin until at least the pregnancy test * Affiliation or beneficiary of a social security scheme or equivalent for both partners of the couple if applicable * Free and informed consent signed by the unmarried woman or both members of the couple * Couples and unmarried women meeting the conditions for access to PMA according to the French bioethics law Exclusion Criteria: * Endometriosis stage III or IV * History of ectopic pregnancy * ≥ 3 spontaneous miscarriages * Single woman or couple where one of the two partners (or both) is (are) under the protection of justice, under guardianship or under curatorship * Single woman or couple who have already participated in the study once * Single woman or couple participating in another interventional clinical study

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Conditions

The condition(s) this trial relates to.

infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infertility Intrauterine insemination (IUI)

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

4 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Could waiting just 6 more hours boost IUI success?

What the study statuses mean