University Hospital, Toulouse

This study tests whether performing intrauterine insemination (IUI) at 42 hours after a hormone trigger shot leads to more live births than the standard 36-hour timing. About 692 women with infertility will be randomly assigned to one of the two timing groups. The goal is to see …

This phase 2 trial tests whether injecting stem cells from fat tissue directly into finger ulcers can help them heal in people with scleroderma. The study will compare the stem cell treatment to a placebo in 32 adults who have at least one painful, non-healing finger sore. The go…

This early study tests whether injecting stem cells from donated fat tissue can help heal complex anal fistulas in people with Crohn's disease who haven't gotten better with standard treatments. Nine adults will receive the stem cell injection and be followed for six months to ch…

This study looks at women with postmenopausal osteoporosis who have been on denosumab for at least two years and are now stopping it. Stopping denosumab can cause a rapid bone loss and increase fracture risk. The trial compares two strategies using zoledronic acid infusions: one …

This study compares two treatments for a condition called primary aldosteronism, where a small adrenal gland tumor causes high blood pressure. One treatment is laparoscopic surgery to remove the tumor; the other is radiofrequency ablation (RFA), which uses heat delivered through …

This study looks at whether placing a temporary balloon in the stomach can help control asthma in people who are obese. About 84 adults with uncontrolled asthma and obesity will either get the balloon plus diet and exercise, or just diet and exercise. The main goal is to see if a…

This study looks at two ways to treat a fast, dangerous heart rhythm called ventricular tachycardia in people with coronary artery disease and relatively good heart function. One treatment uses a catheter to burn the tiny area causing the problem (radiofrequency ablation), and th…

This study tests whether a bedside device called Quantra can help doctors manage bleeding during liver transplant surgery. The device measures blood clotting in real time to guide transfusion decisions. Researchers will compare this approach to standard care in 56 adults receivin…

This study collects breath samples from 235 people with type 2 diabetes or obesity to improve a device that estimates blood sugar from exhaled air. Participants simply breathe into a portable analyzer. The goal is to refine the device's algorithm so it can one day offer a painles…

This study tests whether a special PET scan tracer called [18F]-DPA-714 can detect brain inflammation in people with autoimmune encephalitis (AE). Researchers will compare scans from 40 newly diagnosed AE patients to healthy volunteers. If the tracer works well, it could become a…

This study tests whether measuring HIV drugs in hair can reliably show if patients are taking their medication as prescribed. Researchers will collect hair and blood samples from 30 HIV patients who are known to be compliant. The goal is to see if hair can be a simple, non-invasi…

This study looks at whether measuring a substance called D-lactate in spinal fluid can help doctors diagnose meningitis (a brain infection) in patients who have a brain drain (ventriculostomy). About 185 adults with suspected meningitis will have their spinal fluid tested. The go…

This study looks at whether emergency doctors using a lung ultrasound in an ambulance can better diagnose the cause of severe breathing trouble. About 40 adults with serious shortness of breath will be included. The goal is to see if the ultrasound helps doctors choose the right …

This study aims to confirm if a test using a sample of amniotic fluid can accurately predict how well a baby's kidneys will work after birth. Researchers will analyze 78 fetuses with kidney and urinary tract malformations from hospitals across France. The goal is to see if this t…

This study is testing whether a special PET scan called 18F-FES PET/CT can find endometriosis lesions more accurately than standard MRI. The scan measures estrogen receptors in the lesions, which may help doctors understand pain levels and guide treatment. About 20 women with end…

This study looks at whether using lung and heart ultrasound can help emergency doctors give the right treatment faster to older adults (over 65) who come to the ER with sudden breathing trouble. About 504 participants will be enrolled. The goal is to see if ultrasound reduces the…

This study aims to see if analyzing DNA from fluid left over after a lung nodule biopsy can better detect cancer. About 60 adults with small lung nodules (20 mm or less) will have a standard bronchoscopy, and the leftover fluid will be tested for cancer-related DNA changes. If su…

This study tests whether wearing a compression bandage after mastectomy can prevent lymphoceles—painful fluid pockets that often form after surgery. About 84 breast cancer patients will either get a drain plus bandage or just a drain. The goal is to see if the bandage reduces flu…

This study tests whether taking a daily low-dose aspirin (150 mg) starting early in pregnancy can prevent preterm preeclampsia in first-time mothers who became pregnant through assisted reproductive technology (ART) like IVF. About 1,164 women will be randomly assigned to receive…

This study tests the WHO's ICOPE program, which screens older adults for early signs of decline in mobility, memory, nutrition, vision, hearing, and mood. If problems are found, a personalized care plan is created. The goal is to see if this approach can prevent or delay loss of …

This pilot study tests whether a 4-week home-based cognitive strategy training program can help adults with chronic stroke become more independent in daily activities like dressing and cooking. Eighteen participants will work with an occupational therapist in their own homes. The…

This study is testing whether a short, guided breathing exercise (called cardiac coherence) can help reduce anxiety in people who are nervous about getting an MRI. Sixty adults who are anxious about their MRI will either do the breathing exercise or just read an information sheet…

This study tests whether a steroid injection (betamethasone) guided by ultrasound can quickly reduce pain from a degenerative meniscus tear in the knee. About 152 adults with persistent knee pain will receive either the steroid or a placebo injection. The main goal is to see if p…

This pilot study tests a mechanical in-exsufflator (MIE) device that helps ALS patients cough more effectively by pushing air in and then pulling it out. The goal is to see if daily use for four weeks can maintain or improve lung function. The study will enroll 36 adults with ALS…

This study tests whether a two-week intensive rhythmic dance program can improve learning ability in children with cerebral palsy. Six children aged 6-17 will take dance classes and be assessed repeatedly on motor, cognitive, and social goals. The goal is to see if dance, which c…

This study tests whether a 6-month adapted physical activity program can improve endurance in children and teenagers with Marfan syndrome. About 30 participants aged 7 to 17 will take part. The program focuses on safe, tailored exercises to help them be more active without puttin…

This study looks at whether a single educational session about the benefits of exercise can help people with Crohn's disease or ulcerative colitis (IBD) become more physically active. The goal is to reduce fatigue, improve digestion, and enhance quality of life. About 71 adults w…

This study tests whether a 6-month adapted physical activity program can improve endurance and quality of life in 30 children and teenagers with osteogenesis imperfecta (brittle bone disease). Participants will do supervised exercises designed for their condition. The main goal i…

This study tests whether a personalized brain-training therapy (neurofeedback) can improve arm movement in people who recently had a stroke. About 44 participants will either receive standard or personalized neurofeedback during 15 sessions over three weeks. The goal is to see if…

This study tests whether a support group for siblings (ages 2-18) of teenagers with anorexia nervosa is acceptable and helpful. About 24 siblings will attend group sessions and fill out questionnaires about their experience and quality of life. The goal is to see if this kind of …

This study tests a wearable neuroprosthesis that uses mild electrical stimulation to help stroke survivors open their hand. Two participants will use the device at home for one year to see if it improves daily activities and quality of life. The goal is to understand how well the…

This study tests a 100% remote education program for adults with moderate depression who recently started antidepressants. The program aims to help them stick with their medication and improve their symptoms. Researchers will compare the program to usual care in 220 participants …

This study tests whether learning music—rhythm, singing, and body movements—can improve attention and thinking in people with schizophrenia. About 120 adults with stable schizophrenia will take part. The goal is to see if music-based training is a more engaging and effective way …

This study looks at whether a guided exercise program can improve quality of life and lower healthcare costs for women with breast cancer who are undergoing treatment like surgery, chemo, or radiation. About 866 women will be split into two groups: one gets the exercise program, …

This study looks at whether a special wrap treatment, done by a nurse after a bath, can reduce skin discomfort in people with moderate to very severe hereditary ichthyosis. About 34 adults will receive three wraps over a short period. The main goal is to see if at least a 3-point…

This study tests a special hand device that helps people who had a stroke and cannot open their hand to grab things. The device is designed to let users control it themselves to pick up, move, and release objects like a glass or spoon. Researchers will compare how well 30 partici…

This study tests custom-made 3D-printed stents for people with narrowed airways. The stents are designed to fit each person's unique airway shape, which may reduce serious complications like stent movement or blockage. About 30 adults with severe symptoms will receive the stent a…

This study tests a home grip assistance glove (SaeboGlove) to help stroke survivors use their weaker arm in everyday tasks. About 100 adults who had a stroke more than three months ago and have trouble opening their hand will try the glove at home. Researchers will compare how we…

This study follows 200 head and neck cancer patients who need facial reconstruction using a bone flap from another part of the body. Researchers will track their medical visits, treatments, and costs over time using national health data. The goal is to understand typical care pat…

This study explores whether a high-density mapping system can precisely locate the tiny heart structures responsible for a common type of fast heartbeat called AVNRT. Researchers will map the hearts of 20 people—half with the condition and half without—using a special catheter an…

This study aims to understand why lymphedema develops by comparing gene activity in swollen versus healthy limbs. Researchers will take tiny tissue samples from 60 adults with primary or secondary lymphedema. The goal is to identify molecular differences that could point toward f…

This study is building a large collection of blood, urine, saliva, and other samples from 3000 people with lung nodules or lung cancer. Researchers hope to find biological markers that can help diagnose lung cancer earlier, predict how the disease will progress, and guide treatme…

This study is creating a collection of blood, urine, and leftover surgical tissue from 350 patients with bone, calcium, and growth plate disorders. The goal is to better understand how these diseases progress and to find markers that could predict outcomes. No new treatments are …

This study interviews children aged 10 and older who had Guillain-Barré Syndrome two to five years ago. Researchers want to understand their emotional and psychological experiences, including any lingering anxiety or depression. The goal is to improve care and mental health suppo…

This study follows 2,000 people with multiple myeloma in the West-Occitanie region of France to understand how they are treated in real life and how their quality of life changes over time. Participants fill out questionnaires about their well-being and stress at key points durin…

This study aims to collect blood samples and medical data from 3000 people with autoimmune diseases like lupus, scleroderma, and myositis. Researchers will use these samples to identify new biomarkers and better understand the diseases. The goal is to support future research into…

This study tests whether drinking 1.5 liters of water before an MRI scan can give doctors clear images of the small bowel in people with Crohn's disease, compared to the standard polyethylene glycol (PEG) prep. About 194 participants will be randomly assigned to water or PEG, and…

This study is a national registry in France that collects information on adults newly diagnosed with immune thrombocytopenia (ITP) or autoimmune hemolytic anemia (AIHA). It aims to describe how these diseases progress and how well treatments work in real life. Researchers will tr…

This study looks at 100 healthy adults over 60 to see if brain scans and eye-tracking tests can predict memory changes. Researchers focus on a small brain area called the locus coeruleus, which is linked to early Alzheimer's changes. Participants will have MRI scans and do comput…

This study aims to create a collection of blood and urine samples from 300 people with Marfan syndrome or related conditions. Researchers will use these samples to study how the disease works and find clues that might predict how it will progress. Participants provide extra sampl…

This study is testing a new method to measure allergy-related substances (IgE) in blood and urine. Researchers want to see if this new technique works as well as current tests. About 1,376 children and adults with allergies will provide blood and urine samples during routine visi…

This study looks at 150 people with memory problems caused by damage to specific brain areas (medial temporal lobe). Researchers will use MRI scans and memory tasks to see how these patients can still learn new information. The goal is to understand which brain parts are importan…

This study is examining heart valve tissue from 100 people undergoing surgery for aortic stenosis to see how often ATTR amyloid deposits are present. Researchers will use mass spectrometry to identify the type of amyloid. The goal is to better understand the link between amyloido…

This study is looking at the gum health and mouth bacteria of 30 women who have had three or more miscarriages. Researchers want to see if there is a connection between certain bacteria in the mouth and pregnancy loss. Participants will have a standard dental checkup and provide …

This study looks at whether women with high blood pressure who skip their medication have more sexual problems than those who take it regularly. Researchers will compare sexual function in 348 women using questionnaires and blood tests. The goal is to understand if not taking med…

This study collects tumor tissue and medical information from 1,500 people with pancreatic cancer. The goal is to build a large biobank that scientists can use to better understand the disease and develop new treatments. Participants undergo standard diagnostic procedures, and no…

This study involves 20 people with drug-resistant epilepsy who already need brain electrodes to find where seizures start. Researchers will test if using a wider range of electrical stimulation frequencies helps doctors better map the seizure zone compared to standard methods. Th…

This study aims to create a collection of blood and urine samples from 100 people with Noonan syndrome. Researchers will use these samples to study how the disease works and look for factors that predict how it will progress. The study does not test any treatment, but may help gu…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biomarkers that predict how well a patient responds to treatment. The …

This study looks at how common tooth staining is in children who had very high bilirubin levels (jaundice) early in life. Researchers will check 120 children with certain liver conditions to see if their teeth are discolored and whether that affects their daily life. The goal is …

This study aims to create a large collection of blood samples and medical information from 800 people with autoimmune or inflammatory skin diseases. Researchers will use these samples to find new biomarkers and better understand what causes these conditions. The goal is to help d…

This study looks at why some people with Parkinson's disease feel pain. Researchers will use brain scans to see how serotonin, a natural chemical, is involved. About 34 adults with Parkinson's will take part. The goal is to better understand pain, not to test a new treatment.

This study collects blood samples and health data from 1000 people with rare neurological diseases that may be caused by the immune system attacking the body. The goal is to build a large biobank that researchers can use to discover new biomarkers and develop better treatments. P…

This study examines bacteria living on heart valves in 200 patients having aortic valve surgery. Researchers want to see if these bacteria are linked to serious complications after surgery, like stroke or infection. The goal is to better understand how oral health and heart disea…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study is looking for 400 people with multiple sclerosis to see if a substance in urine, called S1P, can tell doctors how well the bladder is working. Right now, checking for bladder problems requires a tube inserted into the bladder, which is uncomfortable. If S1P levels in …

This study looks at how sleeping at high altitude (2,877 meters) affects the sleep of 32 employees at the Pic du Midi observatory. Researchers will use sleep monitoring to compare nights spent at the summit with nights spent at home. The goal is to understand sleep changes in peo…

This study tests whether a monthly monitoring program (ICOPE) can help detect early signs of decline in people over 70 with multiple myeloma. The goal is to prevent loss of independence. About 30 participants will use a digital app or chatbot for one year to track their health.

This study will enroll 5,000 adults with kidney disease or at risk for it, including transplant recipients. Researchers will analyze blood and urine samples to find molecular patterns that predict disease progression, complications, or treatment response. The goal is to improve r…

This study looks at a common problem after bowel surgery called postoperative ileus, where the bowel temporarily stops working. The researchers want to test a scoring system called IFEED to see if it can better define this condition and predict how long patients stay in the hospi…

This study takes skin or blood cells from 20 people with eye malformations and turns them into stem cells, which are then grown into tiny 3D eye-like structures (organoids) in a dish. Researchers will study these mini eyes to understand what goes wrong during development and test…

This study collects tumor, blood, urine, and stool samples from 1000 adults with suspected or confirmed bladder cancer. The samples are stored securely for future biological and genetic research. The goal is to build a resource that can help scientists better understand the disea…

This study is looking at whether a rare condition called carotid web, which is a small flap in the neck artery that can raise stroke risk, runs in families. Researchers will use a simple neck ultrasound to screen close relatives (like siblings or children) of people already diagn…

This study aims to improve how acyclovir is dosed in people with obesity. Researchers will measure lean body mass and kidney function in 20 healthy volunteers with different BMIs to see if these factors predict how the body clears the drug. The goal is to create better dosing gui…

This study looks at how Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a rare condition where the uterus and vagina are underdeveloped, affects women's overall quality of life, sexual health, and mental well-being. Researchers will compare 102 women with MRKH to a control group …

This study looks at whether detecting a specific type of brain wave, called fast-ripples, can help doctors better plan surgery for people with epilepsy that doesn't improve with medication. About 440 adults will take part, with half getting the new brain wave test during their st…

This study looks at whether adding a steady beat helps children with cerebral palsy or coordination disorders learn dance moves more easily. About 68 children aged 8 to 16 will take part, including those with and without movement problems. Researchers will compare how well they r…

This observational study looks at the bacteria in dental plaque of 170 people with obesity (BMI 30+) who are scheduled for bariatric surgery. Researchers want to see if the types and amounts of mouth bacteria differ between those with obesity (BMI 30-35) and those with morbid obe…

This study looks at whether inflammation inside the heart plays a role in arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare heart condition. Researchers will measure inflammatory markers in the blood of 80 participants, including people with ARVC and healthy controls…

This study looks at pain in people with idiopathic REM sleep behavior disorder (iRBD), a condition that strongly increases the risk of developing Parkinson's disease. Researchers will compare pain levels and patterns between 24 participants with iRBD and a control group with narc…

This study uses small motion sensors to detect internal tremors—a common but hard-to-measure symptom—in people with Parkinson's disease. Researchers will compare 60 participants (30 with Parkinson's and 30 healthy volunteers) to see if a specific 4-6 Hz rhythm can be identified. …