University Hospital, Toulouse

This study tests whether adding avacopan to standard treatment helps people with severe ANCA vasculitis—a rare autoimmune disease that attacks the kidneys. About 130 adults with rapidly worsening kidney function will receive either avacopan or a placebo alongside usual drugs and …

This study tests whether rapamycin is safe and well-tolerated in teenagers aged 12 to 17 with familial adenomatous polyposis (FAP), a condition that causes many polyps in the colon. Researchers will give two low doses of rapamycin and monitor side effects closely. The goal is to …

This study tests a new care pathway for people with epilepsy who are starting or switching anti-seizure medication. For six months, participants will be monitored remotely by a nurse to help detect side effects and seizure changes early. The goal is to improve medication adherenc…

This study tests whether treating children with uncomplicated appendicitis using antibiotics alone works as well as surgery. About 724 children aged 5 to 15 will be randomly assigned to receive either antibiotics or an operation. The goal is to see if the antibiotic approach lead…

This early-stage trial is testing whether stem cells taken from donated fat tissue are safe when given through an IV to people with mild to moderate Alzheimer's disease. Nine participants will receive increasing doses of the cells and be monitored for side effects over six months…

This study tests whether an artificial intelligence (AI) program that gives personalized diet and exercise advice can help people with non-alcoholic fatty liver disease (NAFLD) reduce liver fat more than standard lifestyle counseling. About 216 adults with NAFLD and overweight wi…

This study looks at 100 healthy older adults (half with a genetic risk for Alzheimer's) to see if simple eye tests and MRI scans can detect early signs of the disease. The goal is to find a non-invasive way to diagnose Alzheimer's earlier, before memory problems start. Participan…

This study aims to see if a special MRI scan can accurately diagnose invasive upper urinary tract tumors. About 178 adults with suspicious findings on a CT scan will receive an MRI, and the results will be compared to standard biopsy or follow-up CT. If successful, MRI could offe…

This study looks at whether eating only during early hours and exercising in the afternoon can prevent muscle loss (sarcopenia) in postmenopausal women who have obesity and type 2 diabetes. About 45 women will follow a 12-week program combining early time-restricted eating with e…

This study tests whether using a TENS device before a back injection can lower pain during the procedure. About 52 adults with chronic low back pain will be randomly assigned to receive either active TENS or a sham TENS. Researchers will compare pain scores and satisfaction betwe…

This study tests a hearing rehabilitation program called Hear2Share for elderly people in nursing homes who have hearing loss. The program uses a simple hearing device and is run by nursing home staff. Researchers will measure how well participants can hear words and how often th…

This pilot study will test whether two intravenous ketamine infusions can quickly reduce symptoms in 38 adults with severe borderline personality disorder. Participants receive the infusions 24 hours apart and are followed for three months. The goal is to see if ketamine, combine…

This study tests whether injections of stem cells from donated fat tissue can help loosen mouth fibrosis in people with systemic scleroderma. Fifty adults with limited mouth opening will receive either stem cell or placebo injections around the mouth and be followed for 24 weeks.…

This study tests whether intensive music-based rhythm training can improve attention, thinking, and reading in children aged 8 to 10 with complex neurodevelopmental disorders (like ADHD plus dyslexia). Six children will take part in a structured program, and researchers will meas…

This study tests whether injecting botulinum toxin (Botox) into the hands or feet can help people with Buerger's disease, a rare condition that blocks blood flow and causes severe pain. Eight adults with critical limb ischemia will receive a single injection session and be follow…

This study looks at whether medical hypnosis or virtual reality can reduce anxiety in adults with acute myeloid leukemia during their first round of chemotherapy. About 99 participants will be split into three groups: standard care alone, standard care plus hypnosis, or standard …

This study tests whether clinical hypnosis and self-hypnosis can improve quality of life and reduce hot flashes in menopausal women who cannot or choose not to use hormone therapy. About 94 women will be randomly assigned to hypnosis or a supportive conversation group. The main g…

This study aims to see if a portable, very low-field MRI can detect brain damage in coma patients after cardiac arrest as well as standard high-field MRI does. Researchers will scan 60 participants (30 coma patients and 30 healthy volunteers) multiple times over two weeks. If suc…

This study will survey 200 adults with Fabry disease to understand how men and women experience different paths to diagnosis. Researchers want to see if symptoms or family screening lead to diagnosis more often in one sex, and how long diagnosis takes. The goal is to identify pat…

This study looks at whether a new observation grid can help doctors and therapists consistently identify early signs of developmental problems in very premature babies (born at 27-32 weeks). Researchers will film 35 infants at home and have different professionals rate their deve…

This study follows 209 adults aged 65 and older who are hospitalized for neurosurgery in France, Spain, or Portugal. Researchers will measure changes in their ability to perform daily activities (like bathing, dressing, eating) from before surgery to 3 months after. The goal is t…

This pilot study will test a flexible, home-based care pathway for 100 people newly diagnosed with Parkinson's disease and their caregivers. The program includes questionnaires and educational tools to help patients and families better understand the disease and manage their care…

This study looks at how brain processes like attention and inhibition help people adapt after hearing loss. Researchers will use EEG to measure brain waves in 90 adults receiving cochlear implants, comparing them to normal-hearing participants. The goal is to find brain markers t…

This study looks at obese people who use a CPAP machine for sleep apnea but may still have low oxygen at night. Researchers will use a special monitor to check breathing in 139 participants. The goal is to find out how common this hidden problem is.

This study looks at whether cannabis byproducts can be found in the sweat of young children (3 months to 3 years) who come to the emergency room with acute cannabis poisoning. Researchers want to know if sweat contamination might affect hair tests used to check for past exposure.…

This study looks at how well platelets work in patients on a life-support machine called ECMO, which helps people with severe lung or heart problems. The goal is to understand why these patients often have dangerous bleeding. Researchers will measure platelet function over time a…

This study tests two artificial intelligence (AI) models that aim to predict how Parkinson's disease will progress and whether medication will cause side effects. Researchers will collect information from 100 people with Parkinson's, including data from a smartwatch and a mobile …

This study aims to translate and adapt an English scale (EmNSA) into French to better assess sensation in the legs of adults with acquired brain injury. Researchers will test the new French version on 50 patients to ensure it is accurate and reliable. The goal is to provide a val…

This study looks at 117 people who had a brain bleed (intracerebral hemorrhage) to understand how inflammation and damage to the brain's protective barrier affect recovery. Participants will get special brain scans and blood tests about 10 days after the bleed. The goal is to lin…

This study looks at how different parts of the brain handle thinking skills like memory, language, and perception. Researchers will test 120 people with brain tumors before and during awake surgery to see which brain areas are active. The goal is to create a detailed map of the b…