Fat stem cells injected into face could ease scleroderma mouth stiffness
NCT ID NCT07326033
First seen Jan 10, 2026 · Last updated Jun 22, 2026 · Updated 20 times
Summary
This study tests whether injections of stem cells from donated fat tissue can help loosen mouth fibrosis in people with systemic scleroderma. Fifty adults with limited mouth opening will receive either stem cell or placebo injections around the mouth and be followed for 24 weeks. The main goal is to see if the treatment improves mouth function and quality of life.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Bordeaux Hospital
Bordeaux, France
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Dijon Hospital
Dijon, France
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Montpellier Hospital
Montpellier, France
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Nantes Hospital
Nantes, France
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Toulouse Hospital
Toulouse, France
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
allogeneic cultured adipose-derived mesenchymal stromal cells (AdMSC)
What this could lead to
If it works, this could offer a new way to reduce mouth tightness and improve eating, speaking, and oral care for people with scleroderma.
What could go wrong
This is an early phase 2 trial with only 50 participants, so results may not apply to everyone. The treatment involves injections and could cause side effects like pain or swelling.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.