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Brain scans probe Serotonin's role in Parkinson's pain

NCT ID NCT06008704

Knowledge-focused Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to understand why some people with Parkinson's disease experience central pain. Researchers will use brain scans (PET and MRI) to examine the serotonin system in 34 participants. The goal is to see how serotonin relates to pain, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal why some Parkinson's patients experience central pain, pointing toward future pain management strategies.
What could go wrong
This is a small, early-stage observational study (34 participants) focused on understanding, not treatment. It may not lead to any direct therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with PD defined according to United Kingdom Parkinson's Disease Brain Bank (UKPDSBB) criteria * Patients with stable anti-parkinsonian treatment for at least 4 weeks prior to inclusion * Patients with a Montreal Cognitive Assessment (MoCA) score \> 25 * Patients with a Hospital Anxiety and Depression Scale (HADS)-D score ≥ 11 * Person affiliated or benefiting from a social security scheme. * Free, informed and written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research). • For patients with pain * Patients with PD-related central pain defined according to the criteria of Marques et al, 2019 * Patients with chronic central pain (i.e. present for at least 3 months) * Patients who have average pain over the previous month according to a VAS ≥ 4. • For patients without pain * Patients who do not have pain defined as VAS ≤ 4, meaning that it does not interfere with daily activity. Exclusion Criteria: * Patients treated with second line therapy * Patients with a history of significant psychiatric pathology according to the investigator * Patients treated with drugs interacting with 5HT1A receptors in the previous 4 weeks * Patients with contraindication to MRI * Patients refusing to be informed of an abnormality discovered during brain imaging * Patients with dyskinesias judged by the investigator to be disabling for imaging. * Patients under guardianship or other legal protection, deprived of their liberty by judicial or administrative decision * Pregnant woman, breastfeeding woman

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centre Hospitalier Universitaire de Toulouse

    RECRUITING

    Toulouse, Haute-Garonne, 31000, France

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