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Uterine infection linked to infertility: antibiotics may boost pregnancy chances

NCT ID NCT07603492

Disease control Sponsor: Faculty Hospital Kralovske Vinohrady Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at 100 women with infertility to see how common chronic endometritis (a long-term inflammation of the womb lining) is and whether antibiotic treatment can improve their chances of getting pregnant and having a healthy baby. Participants will have a camera test and tissue sample, and if inflammation is found, they will receive antibiotics. Researchers will track fertility and pregnancy outcomes for up to a year after treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of women aged 18-40 years with primary or secondary infertility undergoing diagnostic hysteroscopy with endometrial biopsy for infertility evaluation or suspected chronic endometritis (CE). Participants will be recruited at University Hospital Královské Vinohrady and collaborating reproductive medicine centers in Prague, Czech Republic. Eligible participants must provide written informed consent and agree to protocol-defined diagnostic procedures, antibiotic treatment if indicated, and prospective follow-up of reproductive outcomes. The study will include women with previous unsuccessful assisted reproductive technology (ART) cycles, recurrent implantation failure, recurrent pregnancy loss, or unexplained infertility. Approximately 100 participants are expected to be enrolled.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Female participants aged 18-40 years. * Diagnosis of infertility (primary or secondary infertility). * Indication for diagnostic hysteroscopy with endometrial biopsy as part of infertility evaluation. * Suspected or confirmed chronic endometritis. * Ability and willingness to provide written informed consent prior to any study-related procedures. * Willingness to undergo protocol-defined antibiotic treatment. * Willingness to comply with study procedures and follow-up assessments. * Agreement to reproductive outcome monitoring following treatment, including spontaneous conception and pregnancies achieved through assisted reproductive technologies (ART). Exclusion Criteria * Age \>40 years. * Current pregnancy. * Known hypersensitivity or contraindication to tetracycline antibiotics or other study-related antibiotic therapy without a suitable alternative treatment option. * Severe systemic disease or medical condition that, in the opinion of the investigator, could interfere with study participation, safety, or interpretation of study results. * Active malignant disease requiring systemic treatment. * HIV infection or other severe immunodeficiency disorder. * Acute pelvic inflammatory disease or clinically significant active genital tract infection requiring immediate treatment. * Previous participation in this study. * Inability to undergo planned hysteroscopy or endometrial biopsy. * Inability or unwillingness to comply with study procedures or follow-up requirements. * Failure or refusal to provide written informed consent.

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Conditions

The condition(s) this trial relates to.

chronic endometritis endometritis infertility disorder pregnancy disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometritis Hysteroscopy Infertility Pregnancy disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty Hospital Královské Vinohrady

    RECRUITING

    Prague, 14000, Czechia

  • PRONATAL Sanatorium

    RECRUITING

    Prague, 14000, Czechia

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