New study creates ovarian tissue databank to unlock fertility secrets
NCT ID NCT05440617
First seen Jun 27, 2026 · Last updated Sep 17, 2026 · Updated 13 times
Summary
This study collects and stores ovarian tissue from females aged 4 to 35 who choose to freeze a sample before cancer treatment that could harm their fertility. Researchers will also gather medical data and annual surveys for up to 30 years. The goal is to build a national database to better understand ovarian function and long-term reproductive health outcomes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this databank could improve understanding of ovarian function and help develop better fertility preservation methods for cancer patients.
- What could go wrong
- This is an observational study, not a treatment trial. It collects data and tissue for research, so there is no direct benefit to participants. Results may take decades to yield practical insights.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2022
- Expected to finish
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Sep 2041
An estimate. End dates often move.
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Subjects who will undergo gonadotoxic treatment at NCI.
- Ages
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4 to 35 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Provision of signed and dated informed consent/assent form. * Stated willingness to comply with all study procedures and availability for the duration of the study. * Subjects who have planned to undergo OTC for gonadotoxic therapy based on current standard of care. EXCLUSION CRITERIA: -An individual who meets any of the following criteria will be excluded from participation in this study: --Adults subjects with psychological, psychiatric, or other conditions which prevent giving fully informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
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