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Freeze your pain away? cryotherapy trial for endometriosis launches

NCT ID NCT07603960

Symptom relief Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests if whole-body cryotherapy (standing in a -120°C chamber for 3 minutes) can safely reduce pain and improve quality of life in people with endometriosis. Thirty participants with chronic pelvic pain will attend 5 sessions over 4 weeks. Researchers will measure pain changes and collect blood, saliva, and stool samples to understand how the body responds.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women or assigned female at birth * Aged 16 or over * Endometriosis identified at laparoscopy or imaging, performed within the last ten years * Chronic pelvic pain for more than six months * Willing to comply with the treatment * Willing to use effective contraception throughout the trial (if needed) * Willing and able to give informed consent Exclusion Criteria: * Pregnant, breastfeeding or actively trying to get pregnant * Post-menopausal (no periods for \>12 months and not taking hormonal treatments to prevent periods, or bilateral oophorectomy performed) * Previous hysterectomy with bilateral oophorectomy * Raynaud's Disease * Current treatment for malignancy * Diabetes * Known hypothyroidism * Pre-existing or current diagnosis of anaemia * Cardiovascular disease: severe hypertension (180/100, unstable angina, arrhythmia, recent (\<6months) myocardial infarction, peripheral artery disease, cardiac pacemaker, recent (\<6months) stroke or transient ischaemic attack) * Acute kidney and urinary tract diseases * Cryoglobulinemia * Previous venous thromboembolism or peripheral artery occlusive disease * Cold urticaria * Livedo reticularis * Open wounds or ulcers, large-area bacterial and viral skin infections * Uncontrolled seizure disorder * Known coagulopathy (eg von Willibrand disease, haemophilia) * Severe claustrophobia * Acute infections and fever * Intoxication (alcohol, drugs) * Signs or symptoms of cold allergy * Severe wasting diseases * Known Hepatitis B/C and/or HIV (due to Royal Mail restrictions on biospecimen postage)

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Conditions

The condition(s) this trial relates to.

endometriosis Inflammation Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometriosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Institute for Regeneration and Repair, University of Edinburgh and Royal Infirmary of Edinburgh

    RECRUITING

    Edinburgh, Scotland, EH16 4UX, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.