Eyes may reveal hidden clues about endometriosis
NCT ID NCT07232485
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether a simple, non-invasive eye scan can detect signs of inflammation in women with endometriosis. Researchers will compare retinal images from 100 women—half with endometriosis and half without—to see if the eyes can reveal information about this condition. The goal is to find a new way to assess endometriosis without surgery or invasive tests.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a simple, non-invasive eye scan to help diagnose or monitor endometriosis.
- What could go wrong
- This is an early observational study with only 100 participants, so results may not apply to everyone. It's exploring a link, not testing a treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Sep 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
This is a matched case-control study. We will recruit 50 women with endometriosis (case) and 50 women matched for age without endometriosis (controls).
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Participants with a previous surgical or imaging diagnosis of endometriosis * Pre-menopausal women and those assigned female at birth * Aged 18 years and over * A past surgical or imaging diagnosis of endometriosis within the last 5 years from date of consent * Ability to understand and willingness to sign the informed consent form 2. Healthy volunteers * Women and those assigned female at birth * Aged 18 years and over * No history of endometriosis or chronic pelvic pain * Ability to understand and willingness to sign the informed consent form Exclusion Criteria: 1. Participants with a previous surgical or imaging diagnosis of endometriosis * The subject has donated blood (450 ml) within the last 4 weeks * Known reproductive tract malignancy * Ocular Diseases: * Subjects with clinically diagnosed glaucoma, optic neuropathy, optic neuritis, cataracts, or other conditions that affect the ocular structures. * Subjects with age-related macular degeneration, retinal vascular diseases, or other retinal disorders. * Subjects with any other ocular conditions that may influence the retinal or optic nerve structure. * Refractive Errors: * Subjects with high myopia (\>6 diopters) or high hyperopia (\>3 diopters). * Subjects with significant astigmatism (\>2 dioptres) or other refractive errors. * Ocular Surgery History: Subjects with a history of ocular surgery, particularly involving the lens, cornea, retina, or optic nerve (e.g., laser vision correction, retinal surgeries, etc.). * Subjects with significant ocular trauma, corneal abnormalities, or active ocular infections that may interfere with OCT imaging. * Subjects with diabetes mellitus 2. Healthy volunteers * The subject has donated blood (450 ml) within the last 4 weeks * Known reproductive tract malignancy * A history of symptoms suggestive of endometriosis or chronic pelvic pain * Ocular Diseases: * Subjects with clinically diagnosed glaucoma, optic neuropathy, optic neuritis, cataracts, or other conditions that affect the ocular structures. * Subjects with age-related macular degeneration, retinal vascular diseases, or other retinal disorders. * Subjects with any other ocular conditions that may influence the retinal or optic nerve structure. * Refractive Errors: * Subjects with high myopia (\>-6 dioptres) or high hyperopia (\>+6 dioptres). * Subjects with significant astigmatism (\>2 dioptres) or other refractive errors. * Ocular Surgery History: Subjects with a history of ocular surgery, particularly involving the lens, cornea, retina, or optic nerve (e.g., laser vision correction, retinal surgeries, etc.). * Subjects with significant ocular trauma, corneal abnormalities, or active ocular infections that may interfere with OCT imaging. * Subjects with diabetes mellitus
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Edinburgh
RECRUITINGEdinburgh, Scotland, EH16 4UU, United Kingdom
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Other studies related to the condition(s) this trial covers.
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