Could a Full-Body scan replace surgery for endometriosis diagnosis?
NCT ID NCT07523997
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing whether a special full-body PET/CT scan can spot endometriosis without needing surgery. Up to 30 women with suspected endometriosis will get two scans using different tracers that highlight bleeding and scarring. The scan results will be compared with findings from their planned surgery to see if the scan works.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 68Ga-FAPI and 18F-GP1 radiotracers
- What this could lead to
- If successful, this could provide a non-surgical way to diagnose endometriosis, reducing diagnostic delays and surgical risks.
- What could go wrong
- This is a small early study with only 30 participants, and the tracers may not clearly distinguish endometriosis from other conditions. The scans also involve radiation exposure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2026
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
30 patients in NHS Lothian with clinically diagnosed endometriosis due to undergo confirmatory laparoscopy in the subsequent four months will be recruited. All subjects recruited for the study will be able to withdraw from the study at any time. The patients will be referred to the study by their treating physicians to investigate clinically diagnosed endometriosis. We will not recruit or enroll healthy volunteers in this study.
- Ages
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18 to 60 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Chronic pelvic pain * Clinical/radiological diagnosis of likely endometriosis and due to undergo confirmatory laparoscopy in the subsequent four months Exclusion Criteria: * Inability or unwilling to give informed consent * Actively trying to conceive, pregnant or breastfeeding * Post menopausal (no periods for \>12 months and not taking hormonal treatments to prevent periods or bilateral oophorectomy performed) * Previous hysterectomy * Confirmed or suspected pelvic malignancy * Contraindication to MRI (ferromagnetic material in the body, metallic device implantation or claustrophobia) * Contraindication to buscopan (e.g. glaucoma, unstable cardiac disease, arrythmias, myasthenia, previous hypersensitivity to buscopan) * Taking part in a CTIMP or interventional non-CTIMP study * Previous severe pelvic inflammatory disease * Previous peritonitis
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh
RECRUITINGEdinburgh, City Of Edinburgh, EH16 4UU, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Appendix: the hidden driver of endometriosis pain?
- Allergy pill put to the test against endometriosis pain
- Can ultrasound and tissue clues reveal which endometriosis lesions carry cancer risk?
- Can AI personalize exercise to ease pelvic pain?
- Can AI learn to spot endometriosis and fibroids on ultrasound?