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Does endometriosis surgery harm fertility? new study investigates

NCT ID NCT07469007

Knowledge-focused Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study looks at how surgery for severe deep endometriosis impacts a woman's egg supply, measured by a hormone called AMH. Researchers will follow 100 women aged 18 to 39 for 12 months after surgery. The goal is to see if the procedure lowers AMH levels, which could help guide decisions about fertility preservation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors decide whether to recommend fertility preservation before surgery for deep endometriosis.
What could go wrong
This is an observational study, not a treatment trial. It only measures changes in ovarian reserve and does not test a new therapy or cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 39 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female, aged 18 to 39 years old; * Suspected severe deep posterior pelvic endometriosis on reference pelvic MRI (ovarian kissing, obliteration of the pouch of Douglas) with concordant clinical examination, or confirmed severe deep posterior pelvic endometriosis during exploratory laparoscopy; * Patient affiliated with or covered by a social security plan; * Patient having been informed and having given her free, informed, and written consent Exclusion Criteria: * Presence of ovarian involvement defined by the presence of at least one endometrioma \>5 mm; * History of surgery for severe deep endometriosis; * Severe preoperative premature ovarian insufficiency (defined by AMH \<1ng/mL and antral follicle count \<8); * Concurrent use of GnRH agonist therapy at or within the preceding 3 months of enrollment; * BMI \>35 kg/m²; * Menopausal status; * Patient participating in another trial with an exclusion period that has not yet expired at the time of screening; * Protected patient: adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision; * Pregnant, breastfeeding, or postpartum woman.

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Conditions

The condition(s) this trial relates to.

endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometriosis Ovarian reserve

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Clinique la croix du sud

    RECRUITING

    Quint-Fonsegrives, 31130, France

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