ENDOMETRIOSIS

This Phase 3 trial tests whether taking Elagolix, a hormone-blocking drug, before IVF can increase live birth rates in women with endometriosis. About 97 women will receive either Elagolix or a placebo before their IVF cycle. The goal is to see if this pre-treatment improves the …

This study is testing a new robotic surgery system (Medtronic Hugo™) to see if it is safe and works well for hysterectomy. About 70 adult patients with conditions like fibroids, endometriosis, or certain cancers will have their surgery using this robot. The main goal is to see ho…

This study tests whether giving an anti-TNFα drug (a type of anti-inflammatory) a few days before transferring a frozen embryo can improve pregnancy rates in women with endometriosis who have already had one failed IVF cycle. About 145 women will receive either the drug or standa…

This study looks at whether a simple saliva test (Ziwig Endotest) can help doctors make better decisions about managing endometriosis in women with chronic pelvic pain but unclear imaging results. Over 2,500 women will provide a saliva sample, and researchers will compare treatme…

This study tests whether a special PET/MRI scan can find endometriosis more accurately than current methods like ultrasound or MRI alone. About 60 women with suspected endometriosis will get the scan before surgery, and results will be compared to surgical findings. If successful…

This study was designed to check how well a new saliva test, called Endotest®, can diagnose endometriosis. Researchers planned to test the test's repeatability, how time of day affects results, and sample stability. The study was withdrawn before enrolling any participants, so no…

This study tests a new ultrasound technique called SPG to diagnose superficial endometriosis, a common but hard-to-see form of the disease. Researchers will compare the ultrasound results with the standard surgical diagnosis in 50 women. If successful, this could provide a faster…

This study planned to check if a specific MRI technique (3DT1) can accurately find superficial endometriosis, compared to the usual method of looking inside the belly with a camera (laparoscopy). It was designed for adults scheduled for exploratory surgery and a pelvic MRI. Howev…

This study compares two types of radiation therapy—proton therapy and standard intensity-modulated radiation therapy (IMRT)—given after surgery for cervical or endometrial cancer. The goal is to see if proton therapy causes fewer bowel side effects. About 120 women will fill out …

This study aimed to see if adding ketamine to standard anesthesia during endometriosis surgery could lower pain afterward. It was designed for adults with chronic pelvic pain and central sensitization, but the trial was withdrawn before enrolling any participants. No results are …

This Phase 3 study tests whether a new drug, KLH-2109, works as well as an existing treatment (leuprorelin) for reducing pelvic pain in endometriosis. About 288 premenopausal women with confirmed endometriosis will take part. The main goal is to see if KLH-2109 can lower daily pa…

This study aimed to see if a synthetic THC pill (Marinol) could safely reduce chronic pelvic pain in women with endometriosis. It planned to enroll up to 75 women aged 18-64 and give them THC or a placebo for 8 weeks. However, the study was withdrawn before any participants were …

This study tests whether adding the drug elagolix to birth control pills can reduce moderate to severe pain from endometriosis. About 800 premenopausal women with surgically confirmed endometriosis will take either elagolix plus birth control or a placebo for 3 months, then all w…

This study looks at two different hormone treatments for endometriosis, a condition that causes pelvic pain and infertility. Both treatments combine a progestin with a natural estrogen patch. The goal is to see which one women are more satisfied with after 6 months. The study inv…

This study tests a smartphone app called Lyv Endo designed to help women with endometriosis manage their symptoms and improve their quality of life. The app is used alongside standard medical care. The trial involves 400 women in France who have confirmed endometriosis and bother…

This study aimed to see if newer MRI techniques could better detect endometriosis, a condition where tissue similar to the uterine lining grows outside the uterus, causing pain and scarring. The plan was to compare MRI results with standard ultrasound and laparoscopy. However, th…

This study looks at whether certain genetic changes (mutations) in endometriosis tissue are linked to resistance to progesterone therapy. Researchers will compare tissue samples from 135 women with and without endometriosis. The goal is to better understand why some cases don't r…

This study follows 5,000 women with endometriosis who are undergoing in vitro fertilization (IVF) to see how the disease affects their chances of having a baby. Researchers will track live birth rates, pregnancy complications, and other outcomes. The goal is to better understand …