ENDOMETRIOSIS

This phase 3 trial tests whether taking Relugolix combination therapy (Rel-CT) right after endometriosis surgery leads to better quality of life and less chance of the disease coming back. About 110 women having laparoscopic or robotic surgery for endometriosis will be randomly a…

This study tests whether goserelin acetate, a drug that temporarily stops menstruation (like a short-term menopause), can reduce liver fat in women with endometriosis who also have fatty liver disease. Researchers will measure liver fat and stiffness using ultrasound in 62 women …

This study tests whether giving patients a special nutritional drink (immunonutrition) before bladder removal surgery can reduce complications like infections. About 232 adults having open cystectomy for various bladder conditions will be randomly assigned to receive the drink or…

This study is for women under 39 with advanced endometriosis (stage III-IV) who want to get pregnant. It compares two approaches: having surgery to remove endometriosis lesions before trying IVF, versus going straight to IVF without surgery. The goal is to see which path leads to…

This study tests whether a hormone-suppressing drug called Relugolix CT (Myfembree) can reduce pelvic pain, inflammation, and pain sensitivity in women with endometriosis. Researchers will measure changes in blood markers and brain scans in 130 participants over several months. T…

Stanford University is studying the da Vinci Xi robotic system in 250 children and teens aged 6-21. The goal is to see if the robot is safe and works well for various surgeries like gallbladder removal or lung procedures. Participants must weigh at least 15 kilograms and have not…

This study tests whether a capsule called Indinol Forto works as well as the standard pill Visanne for reducing pelvic pain from endometriosis. About 290 women aged 18 to 45 who have been diagnosed with endometriosis through surgery will take one of the two treatments for several…

This study compares two surgical methods for treating ovarian endometriomas (cysts caused by endometriosis): standard cystectomy (removing the cyst wall) and argon plasma coagulation (using a gas-based tool to destroy the cyst lining). The goal is to see which method better prese…

This study looks at whether having surgery to remove deep endometriosis from the bowel before IVF helps women with infertility get pregnant. About 120 women with painful symptoms and trouble conceiving will be randomly assigned to either surgery followed by IVF or IVF alone. The …

This study looks at whether giving a GnRH agonist before a frozen embryo transfer can help women with endometriosis or adenomyosis get pregnant. About 180 women aged 18 to 36 will be randomly assigned to receive either standard hormone support or standard support plus one or two …

This study is testing whether a special full-body PET/CT scan can spot endometriosis without needing surgery. Up to 30 women with suspected endometriosis will get two scans using different tracers that highlight bleeding and scarring. The scan results will be compared with findin…

This study tests a special PET/MRI scan to see if it can accurately diagnose endometriosis. Researchers will scan 24 women with suspected endometriosis and compare the results to surgical findings. If successful, this scan could help diagnose the condition more easily and reduce …

This study aims to find markers in menstrual blood that can diagnose endometriosis, a painful condition affecting many women. Researchers will compare menstrual blood from 250 women with and without endometriosis, and also look at samples before and after surgery in some patients…

This study is testing a new, non-invasive lab test that uses menstrual blood to diagnose endometriosis. Currently, diagnosis requires surgery, which can take years to get. The study will enroll 200 women aged 14-49 to see how accurate the test is compared to standard methods.

This study tests a new blood test called HerResolve™ to see if it can accurately detect endometriosis in women aged 18 to 49 who have symptoms like pelvic pain or abnormal bleeding. About 100 participants will give a blood sample before their scheduled laparoscopy (a surgical pro…

This study is testing whether a special PET scan called 18F-FES PET/CT can find endometriosis lesions more accurately than standard MRI. The scan measures estrogen receptors in the lesions, which may help doctors understand pain levels and guide treatment. About 20 women with end…

This study follows 140 people who previously received High-Intensity Focused Ultrasound (HIFU) for rectal endometriosis. Researchers want to see if the treatment improves quality of life over the long term. Participants fill out online questionnaires to track their symptoms and w…

This study tests whether a 12-week virtual yoga program can reduce pain in women with endometriosis. Researchers will enroll 30 women aged 18-45 who have moderate pain and a confirmed diagnosis. Participants will attend online yoga classes and report their pain levels using quest…

This pilot study tests whether a single, brief mindfulness session before endometriosis surgery can help women cope with pain and use fewer opioids afterward. Twenty adults with endometriosis will be split into two groups: one gets the mindfulness session plus usual care, the oth…

This pilot study tests whether using a dye (indocyanine green) to see the ureters during endometriosis surgery causes less pain than the usual method of placing temporary plastic stents. About 70 women aged 18-50 having deep endometriosis surgery will take part. The goal is to se…

This study tests whether listening to an educational podcast about chronic pelvic pain can improve quality of life, reduce loneliness, and lessen stigma. About 100 adults with chronic pelvic pain or endometriosis will either receive standard care or standard care plus access to t…

This study compares robot-assisted surgery to standard laparoscopic surgery for women with deep endometriosis and adenomyosis who need a hysterectomy. The goal is to see which approach causes fewer complications during and after surgery. About 224 women will take part, and resear…

This phase 2 trial tests a custom high-CBD sublingual product against a placebo in 30 women with endometriosis. Over 12 weeks, researchers will measure changes in pain and quality of life. The goal is to see if cannabinoids can help manage symptoms where few proven options exist.

This study tests if whole-body cryotherapy (standing in a -120°C chamber for 3 minutes) can safely reduce pain and improve quality of life in people with endometriosis. Thirty participants with chronic pelvic pain will attend 5 sessions over 4 weeks. Researchers will measure pain…

This study tests whether a physiotherapy program that combines gentle exercise with pain education can reduce pain and improve daily life for women with endometriosis. About 62 women will take part, with half receiving the combined program and half receiving pain education alone.…

This study tests whether an 8-week group program called PEEPS, which combines education and peer support, can reduce how much endometriosis pain interferes with daily life. Sixty women aged 18-48 with confirmed endometriosis and chronic pelvic pain will either join PEEPS plus usu…

This study tests whether a small electrical device (TENS) can reduce pelvic pain in women with endometriosis or adenomyosis. 92 women on stable hormone therapy will use the device for 45 minutes daily over 4 weeks, rating their pain on a scale. The goal is to see if the device lo…

This study tests whether a device that delivers gentle magnetic pulses to the lower belly can reduce pain and improve quality of life in women with endometriosis. Sixty women will either get real or fake (sham) treatment three times a week for 8 weeks. Researchers will track pain…

This study compares a new surgical technique (IDLnR) with standard laparoscopic surgery for bowel endometriosis. About 192 women aged 18-55 with confirmed bowel endometriosis will be randomly assigned to one of the two surgeries. The goal is to see if the new method leads to bett…

This study tests whether live, online yoga classes (Tele-Yoga) can reduce chronic pelvic pain, fatigue, and improve quality of life in women with endometriosis. About 66 women will be randomly assigned to either Tele-Yoga or usual care. The goal is to see if a gentle, at-home exe…

This study tests if a non-invasive device that stimulates a nerve in the ear can reduce chronic pelvic pain caused by endometriosis. The device is thought to lower inflammation and change brain chemicals that affect pain. Researchers will enroll 72 women with endometriosis to see…

This study compares a home pelvic floor physical therapy program to standard care for 30 women having endometriosis surgery (without hysterectomy). Participants will report their pain and quality of life over the recovery period. The goal is to see if a simple home program can ea…

This study tests whether metformin, a common diabetes drug, can reduce pelvic pain in young women with endometriosis. Fourteen participants will take either metformin or a placebo daily for 6 months and track their symptoms. The goal is to see if this non-hormonal approach offers…

This study tests whether a whole food plant-based diet can reduce pain in women with endometriosis. 120 women aged 18-45 with moderate to severe pelvic pain will be randomly assigned to either follow the special diet or stay on their usual diet for 12 weeks. The goal is to see if…

This study tests an internet-based therapy program for 10 people with endometriosis and chronic pain. The program teaches skills like mindfulness and acceptance to help reduce pain's impact on daily life. Participants work online with a psychologist over several weeks. The goal i…

This study looks at whether changing what you eat and taking probiotics can help reduce chronic pelvic pain in women who have both endometriosis and irritable bowel syndrome (IBS). Researchers will enroll 74 women aged 18 to 50 and randomly assign them to different groups to comp…

This study tests whether a wearable device called NettleEndo, which delivers mild electrical stimulation to the brain, can reduce chronic pelvic pain in women with endometriosis. About 120 women will use the device at home for 20 minutes a day, five days a week, for 12 weeks. Hal…

This study tests whether a series of workshops led by different health experts, plus regular nurse phone calls, can improve quality of life for women with endometriosis. About 260 women with confirmed endometriosis and chronic pelvic pain will take part. The program focuses on ed…

This study tests a new drug called vipoglanstat to see if it can reduce pelvic pain in people with endometriosis. About 190 women aged 18 to 44 with moderate to severe pain will take either the drug or a placebo for four months. The goal is to find a better treatment option for t…

This study tests whether a special pain consultation and education session can help women with endometriosis feel more in control of their pain and improve their quality of life. About 110 women will either receive the new consultation plus usual care, or usual care alone. They w…

This study looks at whether combining pain neuroscience education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related distress in women with endometriosis. About 32 adult women diagnosed with endometriosis will take part. Researchers will tr…

This study tests whether a low-fat plant-based diet can reduce pain and improve quality of life in women with endometriosis. 120 women aged 18-45 with confirmed endometriosis will either follow the diet or stay on their usual diet for 12 weeks. Researchers will measure changes in…

This study looks at how different ovarian stimulation protocols affect blood clotting in 300 infertile women, including those with endometriosis. Researchers will measure clot formation and breakdown before and after treatment. The goal is to understand which protocols pose highe…

This study follows 5,300 women aged 18-42 with endometriosis or adenomyosis to see if these conditions get worse over time. Researchers track pain, bleeding, fertility, and use imaging to monitor changes. They also explore immune system and gut bacteria links. No new treatment is…

This study follows 15,000 women with endometriosis for up to 10 years to see how well different medical and surgical treatments work over time. Researchers will track symptoms, quality of life, disease return, and pregnancy rates. The goal is to better understand the disease and …

This study aims to collect detailed information from 1,000 people in the UK who have endometriosis, a chronic pain condition affecting 1 in 10 women. Participants will use a mobile app to track symptoms, provide biological samples, and wear a smartwatch. The goal is to find bette…

This study aims to understand how stem cells from menstrual blood and the immune system behave differently in women with endometriosis compared to healthy women. Researchers will collect menstrual blood, tissue samples, and questionnaires from 40 women aged 18-45. No treatments a…

This study looks at how the uterus absorbs fluid during early pregnancy, which may affect fertility. Researchers will compare tissue samples from women with and without endometriosis or infertility. The goal is to understand the role of certain proteins in this process. No treatm…

This study aims to create a complex lab-grown model of the endometrium using tissue biopsies from women with and without endometriosis. Researchers will test how different hormone treatments affect the model, with the goal of predicting individual responses. The study involves 90…

This study looks at how pesticides and the bacteria living in the gut and reproductive organs may be linked to infertility in women with endometriosis. Researchers will measure DNA damage and compare these factors between 160 women with and without the condition. The goal is to f…

This study explores whether a simple, noninvasive eye scan can detect signs of inflammation in women with endometriosis. Researchers will compare retinal images from 100 women with and without the condition. If eye scans prove useful, they could offer a new way to monitor the dis…

This study is looking at 60 women who are getting a hormone-releasing IUD (LNG-IUD) to see if the timing of insertion during their menstrual cycle affects whether they develop ovarian cysts. Researchers will use ultrasound to check for cysts at 0, 3, 6, and 12 months after insert…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study looks at 40 women to see if a simple body measurement (anogenital distance) and hormone levels differ between those with severe endometriosis and those without. Participants will provide blood and saliva samples before and after watching an empathy-provoking video. The…

This study listens to 150 people with endometriosis across Europe to understand how they manage their condition every day. Researchers want to learn what makes people feel empowered or abandoned by their support systems. Participants will share their stories through diaries, inte…

This study aims to see if brain imaging can predict which women with severe endometriosis will experience pain relief after surgery. Researchers will scan the brains of 100 women before their operation and then check their pain levels a year later. The goal is to better understan…

This study follows 650 women with endometriosis who want to have children after diagnosis. Researchers compare pregnancy rates and the need for fertility treatments between those who had surgery and those who took medication. The goal is to understand which approach leads to bett…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study is building a national registry to collect data on people with parietal endometriosis, a condition where endometriosis tissue grows in the abdominal wall. Researchers will track those treated with either surgery or a less invasive technique called cryoablation (freezin…

This study looks at endometriosis and adenomyosis, two conditions that affect women's reproductive health. The goal is to find better ways to diagnose these conditions early using a mix of genetic tests, imaging, and artificial intelligence. Researchers will study 530 women, incl…

This study follows 200 adult women who visit the gynecological emergency department for endometriosis or related symptoms. Researchers want to see if emergency care leads to proper follow-up, like specialist visits or imaging. The goal is to understand how well the emergency syst…

This study tests whether a new smartphone app called elleFA can help women with endometriosis track their symptoms and communicate better with their doctors. Twenty pre-menopausal women aged 18 and older will use the app for 6 months, completing monthly surveys and optional daily…

This study looks at 100 women aged 18-39 with severe deep endometriosis to see how surgery impacts their ovarian reserve, measured by AMH levels over 12 months. Researchers want to know if the procedure lowers egg supply, which could help doctors decide when to recommend egg free…

This study looks at how well pelvic organs move in women with endometriosis using dynamic MRI. Researchers want to see if measuring this movement can help diagnose the disease better and explain why some treatments don't work. About 52 women with suspected endometriosis will take…

This study tests a surgical tool called CUSA Clarity that uses ultrasound to selectively remove endometriosis cyst lining while leaving healthy ovary tissue intact. Researchers will examine cyst wall samples from 10 women to see if the tool can spare ovarian tissue, which may hel…