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Could a common diabetes drug ease endometriosis pain?

NCT ID NCT06611501

Symptom relief Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This pilot study tests whether metformin, a drug typically used for diabetes, can reduce pelvic pain in young women with endometriosis. Fourteen participants will take either metformin or a placebo daily for six months and track their symptoms. The goal is to see if this non-hormonal approach can improve pain and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Metformin
What this could lead to
If it works, this could offer a new non-hormonal option to ease pelvic pain in young women with endometriosis.
What could go wrong
This is a very small early-phase trial with only 14 participants. It may not show a clear benefit over placebo, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 14 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 35 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female with surgically confirmed endometriosis, determined at laparoscopy * Current use for at least 2 months duration of a consistent hormonal therapy for endometriosis (either combination hormonal contraceptives or progestin-only therapy) * Current pelvic pain (score ≥ 3 on Visual Analog Scale) that has been present for at least 2 months prior to enrollment * Age 15 years to 35 years and premenopausal * Willingness to comply with visit schedule and protocol Exclusion Criteria: * Pre-menarche or post-menopause * Diagnosis of Type 1 or Type 2 Diabetes Mellitus * Severe renal dysfunction (creatinine \>1.4 mg/dL or eGFR below 45 mL/minute/1.73 m2 * History of lactic acidosis or diabetic ketoacidosis * ALT or AST \> 2.5 times the upper limit of normal * Significant mental or chronic systemic illness that might confound pain assessment or the inability to complete the study * Current/planning pregnancy or breastfeeding * Inability to read English

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Conditions

The condition(s) this trial relates to.

Chronic Pain endometriosis female reproductive system disorder Female Urogenital Diseases Pain Pelvic Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometriosis Pelvic pain

Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.