New scan may spot endometriosis without surgery
NCT ID NCT06377553
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a special PET/MRI scan can find endometriosis more accurately than current methods like ultrasound or MRI alone. About 60 women with suspected endometriosis will get the scan before surgery, and results will be compared to surgical findings. If successful, this could lead to a non-invasive way to diagnose endometriosis and guide treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2025
- Expected to finish
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May 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
In total, 60 subjects with clinically diagnosed endometriosis will be recruited. All subjects recruited for the study will be able to withdraw from the study at any time. The patients will be referred to the study by their treating physicians to investigate clinically diagnosed endometriosis. We will not recruit or enroll healthy volunteers in this study.
- Ages
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18 to 70 years
- Sex
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Female participants only
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: \- Patients with clinical diagnosis of endometriosis, in any stage, candidate for diagnostic overtherapeutic laparoscopic surgery. Exclusion Criteria: * Subjects less than 18 years of age or greater than 70 years of age. * Any contraindication to MRI, including electrical implants, such as cardiac pacemakers or perfusion pumps. MRI non-compatible ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, prosthetic heart valves that are not compatible with the gradient maps of our scanners, metal fragments, shrapnel, metallic tattoos anywhere on the body, tattoos near the eye, steel implants, and/or ferromagnetic objects such as jewelry, or metal clips in clothing that cannot be removed. * History of claustrophobic reactions. * Individuals who do not speak or understand English since providing a translated version of the entire consent form is not practicable * Any contraindication to PET including active breastfeeding (a negative STAT quantitative serum hCG pregnancy test is required on the day of the scan before the subject can participate) * History of research-related radiation exposure exceeding current Radiology Department guidelines (i.e., 50 mSv in the prior 12 months). * QTc\>460msec obtained within 30 days from the PET/MR * eGFR \<60mL/min/1.73m2 obtained within 30 days from the PET/MR * AST \>40U/L and/or ALT \>55 U/L obtained within 30 days from the PET/MR * A greater risk than normal for potential cardiac arrest such as history of non compensated congestive heart failure, poorly controlled arrythmias, symptomatic non compensated cardiopathies. * History of major head trauma (i.e., multiple concussions, traumatic brain injury). * History of bleeding disorders. * Inability to lie comfortably on a bed inside the PET/MRI bore as assessed by physical examination and medical history (e.g., back pain, severe arthritis). * Subjects under the direct supervision of the principal investigator. * Body weight of \> 300 lbs. (weight limit of the MRI table) or BMI \>33.0 per the standard operating procedure of PET/MRI safety at the Martinos Center. * Subjects from any other at-risk populations (e.g., children and minors cognitively impaired persons, prisoners).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School
Charlestown, Massachusetts, 02129, United States
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Other studies related to the condition(s) this trial covers.
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