Pollution and pain: study probes link between chemicals and endometriosis severity
NCT ID NCT06973603
First seen Jun 26, 2026 · Last updated Sep 17, 2026 · Updated 2 times
Summary
This study will investigate whether exposure to persistent organic pollutants (POPs) like dioxins and PCBs is linked to more severe endometriosis. Researchers will analyze blood samples from 650 women with endometriosis living in the Ile-de-France region of France. The goal is to better understand environmental risk factors for this painful condition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could clarify whether certain environmental pollutants worsen endometriosis, potentially guiding future prevention or treatment strategies.
- What could go wrong
- This is an observational study, not a treatment trial. It can only show a link, not cause and effect. Results may not apply to all populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 650 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Dec 2026
An estimate. Start dates often move.
- Expected to finish
-
Dec 2026
An estimate. End dates often move.
- Lead sponsor
-
A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population will be a group of female volunteers who have self-reported endometriosis. The group size will be a random sample of 650 women from the \~10,000 participants included in the ComPaRe-Endometriosis sub-cohort.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ComPaRe participants ⩾ 18 years old. All ComPaRe participants are at least 18 years of age, so our research participants will all be adults. * Having declared in ComPaRe that they had endometriosis * Living in the Ile-de-France region (departments 75, 77, 78, 91, 92, 93, 94 or 95); * Have given electronic consent stating: "By checking this box, I agree to be solicited for research outside ComPaRe"; This criterion is collected at the time of ComPaRe registration, when consent is collected. Participants can withdraw this consent at any time on their secure personal online account on the ComPaRe platform. * Aged ≤ 45 years to avoid including premenopausal or menopausal women; * In possession of MRI images used to diagnose their endometriosis (CD-ROM) that are no more than 5 years old; * Enrolled in or benefiting from a social security scheme. Exclusion Criteria: * \- People with contraindications to blood sampling will not be included in this research: * Known severe anemia * Hemophilia/coagulation disorders/anticoagulant use * People with HIV, HBV or HCV will not be included in this study due to the risk of BSE (Blood Exposure Accident). * Based on factors that may disrupt lipid dynamics and lipid pollutants, the following individuals will not be included: * Pregnant and breast-feeding women * People suffering from any of the following diseases: * Cancer * Morbid obesity (BMI\>40) * Non-alcoholic steatohepatitis (NASH) * Persons under court protection/guardianship/guardianship will not be able to participate in this research.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Endometriosis are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Hôpital Paris Saint Joseph
Paris, 75014, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can Pre-Surgery pelvic floor therapy stop endometriosis pain after the operation?
- Appendix: the hidden driver of endometriosis pain?
- Allergy pill put to the test against endometriosis pain
- Can ultrasound and tissue clues reveal which endometriosis lesions carry cancer risk?
- Can AI personalize exercise to ease pelvic pain?
- Can AI learn to spot endometriosis and fibroids on ultrasound?