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Pollution and pain: study probes link between chemicals and endometriosis severity

NCT ID NCT06973603

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 17, 2026 · Updated 2 times

Summary

This study will investigate whether exposure to persistent organic pollutants (POPs) like dioxins and PCBs is linked to more severe endometriosis. Researchers will analyze blood samples from 650 women with endometriosis living in the Ile-de-France region of France. The goal is to better understand environmental risk factors for this painful condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could clarify whether certain environmental pollutants worsen endometriosis, potentially guiding future prevention or treatment strategies.
What could go wrong
This is an observational study, not a treatment trial. It can only show a link, not cause and effect. Results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 650 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will be a group of female volunteers who have self-reported endometriosis. The group size will be a random sample of 650 women from the \~10,000 participants included in the ComPaRe-Endometriosis sub-cohort.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ComPaRe participants ⩾ 18 years old. All ComPaRe participants are at least 18 years of age, so our research participants will all be adults. * Having declared in ComPaRe that they had endometriosis * Living in the Ile-de-France region (departments 75, 77, 78, 91, 92, 93, 94 or 95); * Have given electronic consent stating: "By checking this box, I agree to be solicited for research outside ComPaRe"; This criterion is collected at the time of ComPaRe registration, when consent is collected. Participants can withdraw this consent at any time on their secure personal online account on the ComPaRe platform. * Aged ≤ 45 years to avoid including premenopausal or menopausal women; * In possession of MRI images used to diagnose their endometriosis (CD-ROM) that are no more than 5 years old; * Enrolled in or benefiting from a social security scheme. Exclusion Criteria: * \- People with contraindications to blood sampling will not be included in this research: * Known severe anemia * Hemophilia/coagulation disorders/anticoagulant use * People with HIV, HBV or HCV will not be included in this study due to the risk of BSE (Blood Exposure Accident). * Based on factors that may disrupt lipid dynamics and lipid pollutants, the following individuals will not be included: * Pregnant and breast-feeding women * People suffering from any of the following diseases: * Cancer * Morbid obesity (BMI\>40) * Non-alcoholic steatohepatitis (NASH) * Persons under court protection/guardianship/guardianship will not be able to participate in this research.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hôpital Paris Saint Joseph

    Paris, 75014, France

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