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New study probes hidden uterine clues behind repeated miscarriages and IVF failure

NCT ID NCT07265505

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 100 women undergoing fertility treatment to understand why some experience repeated implantation failure or pregnancy loss. Researchers will compare immune cells and microbes in the uterus of affected women versus those without such history. The goal is to find biological patterns that could explain these reproductive challenges and guide future personalized care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could identify biological markers that predict implantation failure or miscarriage, paving the way for future personalized treatments.
What could go wrong
This is an observational study, not a treatment trial. It will not directly improve pregnancy outcomes, and findings may not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Apr 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female aged ≥18 and \<36 years * Undergoing assisted reproductive technology (ART) in a fertility center * Covered by the French national health insurance system * Belonging to one of two groups: * Study group: history of recurrent implantation failure (RIF) and/or recurrent pregnancy loss (RPL) * Control group: no history of RIF or RPL Exclusion Criteria: * Pregnant at inclusion * Refusal to provide written informed consent * Antibiotic use within one month prior to endometrial biopsy Positive serology for hepatitis B, hepatitis C or HIV * Uterine anatomical abnormalities (e.g., polyps, cavity-distorting fibroids, untreated hydrosalpinx) * Known chromosomal abnormality in either partner * Known autoimmune disease, thrombophilia, or antiphospholipid antibody syndrome * Persons under legal protection (e.g., guardianship, curatorship)

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Conditions

The condition(s) this trial relates to.

adenomyosis endometrial disorder endometriosis endometritis female infertility habitual spontaneous abortion infertility disorder pregnancy loss, recurrent, 4 pregnancy loss, recurrent, susceptibility uterine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adenomyosis Endometrial diseases Endometriosis Endometritis Infertility, female Recurrent implantation failure Recurrent pregnancy loss

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Service de Gynécologie Obstétrique II et Médecine de la Reproduction - Cochin Hospital

    Paris, IDF, 75014, France

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