Uterine disorder

This study tests whether a temporary uterus transplant from a living donor can allow women with uterine factor infertility—who lack a functioning uterus—to become pregnant and deliver a healthy baby. Recipients receive immunosuppressive drugs to prevent rejection, and the uterus …

This study tests a bivalent HPV vaccine in healthy infants (9 months), toddlers (15 months), children (2-5 years), and unmarried young women (15-20 years) in Ghana. Researchers want to see if the vaccine is safe and triggers a strong immune response, especially when given alongsi…

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This phase 3 trial tests whether adding targeted drugs (trastuzumab and pertuzumab) to standard chemotherapy can better shrink tumors in people with HER2-positive endometrial cancer. The study plans to enroll 360 participants with various stages of the disease. However, the trial…

This study tests a new drug, TER-2013, in people with advanced solid tumors (like breast, ovarian, or lung cancer) that have specific genetic changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and can shrink tumors. About 205 participants will receive th…

This phase 3 trial tests whether adding the experimental drug sacituzumab tirumotecan (sac-TMT) to standard immunotherapy (pembrolizumab) and a targeted therapy (bevacizumab) helps people with metastatic cervical cancer live longer. About 1,000 participants whose cancer has sprea…

This phase 1 study tests a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), in adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the drugs can shrink tumors. Up to 58 people with Kapo…

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This Phase 3 trial tests whether the drug BNT323 (trastuzumab pamirtecan) works better than standard chemotherapy for people with recurrent endometrial cancer that expresses HER2. About 480 participants will be split into two groups based on their HER2 levels. The study measures …

This phase 2 trial tests a drug called lorigerlimab (MGD019) in 47 people with advanced cervical cancer that has spread or come back. The goal is to see if the drug can help control the cancer and improve survival. Participants receive the drug through an IV. The study is current…

This early-phase trial is testing a new radioactive drug that seeks out a protein called Nectin-4 found on many cancer cells. The drug delivers a dose of radiation directly to the tumor, aiming to destroy it while sparing healthy tissue. About 150 adults with advanced bladder, br…

This study tests a new drug called WJB001 combined with various chemotherapy drugs in people with advanced solid tumors that have not responded to standard treatments. The trial has three stages to find the safest dose, check how the body processes the drug, and see if it shrinks…

This study tests whether adding sacituzumab tirumotecan (Sac-TMT) to pembrolizumab helps people with advanced or recurrent endometrial cancer live longer without the cancer getting worse. About 1,100 participants with a specific type of endometrial cancer (pMMR) will receive eith…

This phase II trial is testing whether combining two immunotherapy drugs, nivolumab and ipilimumab, works better than nivolumab alone for women with recurrent endometrial cancer that has a specific DNA repair defect (dMMR). About 81 participants will receive either the combinatio…

Researchers are testing a shorter, adapted form of radiation therapy for people with high-risk endometrial cancer after surgery. The trial enrolls 20 patients and uses daily imaging to adjust the radiation plan to each person's anatomy. Participants receive moderately hypofractio…

This early-phase study tests a new drug called BG-C9074, designed to target and kill cancer cells in people with advanced solid tumors that have not responded to standard treatments. The study will first find the safest dose, then test it alone or with other cancer drugs. About 3…

This study tests an experimental oral drug, GSK5460025, alone or with other cancer drugs, in adults whose solid tumors have specific genetic changes (dMMR or MSI-H). The goal is to see if the drug can shrink tumors and to check its safety. About 47 people with advanced cancers th…

Researchers are testing whether adding an experimental immunotherapy drug called GLS-010 to standard platinum-based chemotherapy, with or without bevacizumab, helps women with persistent, recurrent, or metastatic cervical cancer live longer. The trial enrolls about 424 women aged…

This phase 2 trial tests whether specially selected immune cells taken from a patient's own tumor, grown in large numbers in the lab, and given back along with the drug pembrolizumab (Keytruda) can shrink tumors in people with metastatic colorectal, pancreatic, ovarian, breast, o…

This study tests whether two drugs, abemaciclib and letrozole, can help keep advanced or recurrent endometrial cancer from getting worse. About 32 people with a specific type of estrogen-sensitive cancer will take these pills daily after initial treatment. The goal is to see if t…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This study tests whether a probiotic called EXE-346 can help treat anal high-grade squamous intraepithelial lesions (HSIL) and reduce persistent high-risk HPV infection in people living with HIV. The trial will enroll 90 participants who will take the probiotic or a placebo daily…

This phase II study is testing whether women with certain types of early-stage endometrial cancer can safely receive less aggressive treatment after surgery. The approach is guided by the tumor's molecular profile—either POLE-mutated or p53 wildtype/NSMP. Around 393 participants …

This study tests a new drug called rezatapopt (PC14586) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The drug is designed to reactivate the p53 protein, which normally helps stop cancer growth. The trial will also test rezatapopt combined with th…

This study is testing whether the immunotherapy drug dostarlimab (TSR-042), followed by standard chemoradiation and surgery, can effectively treat advanced mismatch repair deficient (dMMR) solid tumors. About 212 adults with locally advanced dMMR cancers will receive the drug int…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This study compares two surgical approaches for people with advanced ovarian, fallopian tube, or primary peritoneal cancer who have received chemotherapy before surgery. One group will have minimally invasive surgery (small incisions), and the other will have standard open surger…

This study is testing a new experimental drug called GI-101, given alone or with pembrolizumab or lenvatinib, in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to see if the drug is safe and can shrink or control tumors. About 317 adults w…

This study tests a new drug called raludotatug deruxtecan (R-DXd) in people whose high-grade serous ovarian, peritoneal, or fallopian tube cancer has returned after platinum chemotherapy. R-DXd is an antibody-drug conjugate that seeks out cancer cells and delivers a toxic payload…

This study tests a new drug called AZD8205, alone or with another drug (rilvegostomig), in people with advanced solid tumors like breast, ovarian, and lung cancers. The trial has two phases: first to find the safest dose, then to see if it shrinks tumors. About 460 adults whose c…

This phase 2 trial is testing an experimental drug called volrustomig, either alone or with chemotherapy, in people with advanced cervical, head and neck, esophageal, or mesothelioma cancers. The study aims to see if the drug can shrink tumors and how safe it is. About 257 partic…

This study is testing a new drug called ubamatamab, given alone or with another drug called cemiplimab, in people with ovarian cancer or other cancers that have come back after treatment. The main goals are to check safety, find the right dose, and see if the drugs can shrink tum…

This early-stage study tests a two-part system to find and treat metastatic cancer. First, a radioactive tracer is used to spot tumors on a PET scan. Then, a similar radioactive drug is given to deliver radiation directly to the cancer cells. The goal is to see if this approach i…

This early-phase study tests a new drug called BGB-43395 in people with advanced HR+/HER2- breast cancer and other solid tumors. The drug blocks a protein (CDK4) that helps cancer cells grow. Researchers want to find the safest and most effective dose, either alone or combined wi…

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in people with obesity-driven endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare cancer cell activity in t…

This Phase 1 trial tests a new drug called BL-M07D1 in 280 adults with advanced HER2-positive cancers, including breast, lung, and stomach cancers. The study aims to find safe doses and check for early signs of tumor shrinkage. Participants must have tried at least two prior trea…

This study tests whether combining two drugs, pembrolizumab and lenvatinib, can shrink tumors in people with advanced cervical cancer that has stopped responding to initial treatment. The trial enrolls 35 adults whose cancer has spread or cannot be removed by surgery. The goal is…

Researchers are testing a combination of a gonadotropin-releasing hormone agonist injection and the drug letrozole in obese women with early-stage endometrial cancer that has not responded to progestin. The goal is to see if this hormone-blocking approach can shrink tumors and al…

This study tests a new drug called CR-001 in adults with advanced solid tumors that have spread. The goal is to find the safest dose and see if it can shrink tumors. About 290 people will take part in this early-phase trial.

Researchers test whether a combination of GnRHa and letrozole can shrink early endometrial cancer or atypical hyperplasia in non-obese patients who have not responded to progestin therapy. The trial compares this regimen with Diane-35 plus metformin. About 80 participants receive…

This clinical trial is testing whether a combination of two drugs—dostarlimab (an immunotherapy) and niraparib (a PARP inhibitor)—works better than standard chemotherapy for women with a rare and aggressive type of uterine or ovarian cancer called carcinosarcoma. The study will e…

This Phase 3 trial tests whether adding the experimental drug Rina-S to standard care (bevacizumab or monitoring) can help keep platinum-sensitive ovarian cancer from returning after chemotherapy. About 528 participants will receive either Rina-S alone, Rina-S plus bevacizumab, b…

This study compares a new drug called Rina-S to standard chemotherapy (paclitaxel or doxorubicin) in people with endometrial cancer that has returned or worsened after platinum-based chemo and immunotherapy. About 660 participants will be randomly assigned to receive either Rina-…

This early-phase study tests a new radioactive drug, 225Ac-ETN029, in 116 adults with advanced DLL3-positive cancers like small cell lung cancer or neuroendocrine tumors. The main goal is to check safety and find the right dose, while also seeing if the drug can shrink tumors. Pa…

This phase 3 trial compares a new drug called Rina-S to standard chemotherapy in 82 people with platinum-resistant ovarian cancer. Participants are randomly assigned to receive either Rina-S or one of four approved chemotherapies. The goal is to see if Rina-S can delay cancer gro…

This large Phase 3 study tests a new medicine called Sofetabart Mipitecan for people with ovarian, fallopian tube, or peritoneal cancer. It includes two groups: those whose cancer stopped responding to platinum chemotherapy within six months (platinum-resistant), and those whose …

This phase III trial tests whether giving an extra round of chemotherapy and immunotherapy (pembrolizumab) before the usual chemoradiation can help people with high-risk, locally advanced cervical cancer live longer without the cancer growing. About 336 participants will be rando…

This early-stage trial tests a new drug called LY4052031, which is designed to deliver a cancer-killing agent directly to tumor cells that have a protein called Nectin-4. The study includes 420 adults with advanced or metastatic solid tumors such as bladder, breast, lung, and oth…

This trial tests whether screening women with endometriosis for pain complications before surgery, and offering specialized pain care to those who need it, improves their quality of life a year after the operation. Researchers will compare women who receive this extra pain manage…

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This early-stage study tests an experimental drug called IMGS-001 in about 105 people with advanced solid tumors that have come back or not improved after standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. The study has two parts: first, t…

This study tests a new drug, LY4170156, designed to attack cancer cells with a specific marker (folate receptor alpha). It is for people with advanced solid tumors like ovarian, lung, or breast cancer that have not responded to other treatments. The trial has two parts: first fin…

This Phase III trial tests whether adding the drug bevacizumab to a standard chemotherapy plus immunotherapy regimen can help people with a specific type of advanced or recurrent endometrial cancer (pMMR, TP53 mutated). About 255 participants will be randomly assigned to one of t…

This early-phase trial is testing the safety and best dose of two drugs, M1774 and ZEN-3694, given together to patients with recurrent ovarian or endometrial cancer. The drugs work by blocking enzymes that cancer cells need to grow. The study aims to find a dose that is safe and …

This Phase 2 trial tests an oral drug called BAY 2927088 (sevabertinib) in about 111 adults with advanced solid tumors that have HER2 gene mutations. The drug aims to block the abnormal HER2 protein and stop cancer growth. Participants take a 20 mg tablet daily in 3-week cycles u…

This study tests an experimental drug called IDP-001 in people with advanced or metastatic solid tumors, including certain lung, head and neck, and other cancers. The trial has two phases: first to check safety and find the right dose, then to see if the drug can shrink tumors. A…

This phase 3 trial is testing whether a targeted drug (trastuzumab deruxtecan) combined with immunotherapy (rilvegostomig or pembrolizumab) works better than standard chemotherapy plus pembrolizumab for people with advanced or recurrent endometrial cancer that has a specific prot…

This early-stage trial is testing an investigational drug called ARR-002 in adults with advanced or metastatic ovarian or endometrial cancer, including cases that have stopped responding to platinum-based chemotherapy. The main goals are to assess the drug's safety, tolerability,…

This early-stage trial is testing a new drug called CTIM-76 in people with advanced ovarian, testicular, or endometrial cancers that have not responded to standard treatments. CTIM-76 is a bispecific antibody designed to attach to a protein called Claudin-6 on cancer cells and he…

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This study tests a new drug called BNT326, given alone or with other cancer immunotherapies, in about 980 adults with advanced solid tumors that have spread or come back after prior treatment. The goal is to find the best dose and see if it is safe and effective. It is an early-s…

This study is tracking the safety and effectiveness of durvalumab (with or without olaparib) in about 50 Korean patients with endometrial cancer who are already prescribed these drugs. Researchers will follow participants for up to 12 months to see how well the treatment works in…

This study tests a new drug called PYX-201 combined with pembrolizumab in people with advanced solid tumors that have not responded to other treatments. The goal is to find safe doses and see if the combination can shrink tumors. About 220 adults with certain cancers like head an…

This trial compares HHK001, an investigational version of leuprorelin acetate, to Enantone, an approved treatment for endometriosis. Both contain the same active ingredient, but HHK001 uses an updated formulation. The study will enroll 30 women aged 18-45 with endometriosis, who …

This early-phase study tests an experimental therapy called FT836, a ready-made CAR T-cell treatment, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers that have not responded to prior treatments. The main goals are…

This trial is testing whether an experimental drug called TUB-040, when added to standard chemotherapy and a targeted therapy, is safe and tolerable for women with a specific type of advanced ovarian cancer. The study involves about 72 participants whose cancer has returned but s…

This large Phase 3 trial will test a new drug called Rina-S, alone or with bevacizumab, against standard platinum-based chemotherapy for women with ovarian cancer that has returned after initial treatment. About 688 participants will be randomly assigned to receive either the new…

This study tests a radiation treatment called Cesium-131 brachytherapy for women whose cervical or endometrial cancer has returned in the vagina after prior pelvic radiation. Tiny radioactive seeds are placed directly into the tumor to kill cancer cells while sparing healthy orga…

This trial tests whether obese patients with endometrial cancer or a precancerous condition can safely undergo a hysterectomy and weight loss surgery at the same time. Researchers want to see if a fast-track referral process can get patients to surgery within 8 to 12 weeks of dia…

This large Phase 3 study tests a new drug called mocertatug rezetecan (Mo-Rez) against standard chemotherapy for people with endometrial cancer that has progressed after platinum-based chemo and immunotherapy. About 600 participants will be randomly assigned to receive either Mo-…

This early-phase study tests a new drug called JNJ-87890387 in people with advanced solid tumors that have spread or cannot be removed. The drug is designed to help the immune system attack cancer cells. The main goals are to find a safe dose and to check for side effects. About …

This early-phase study tests an experimental drug called JNJ-89862175 in people with advanced solid tumors (lung, kidney, ovarian, or uterine cancers that have spread). The drug is designed to deliver a toxic payload directly to cancer cells. The main goals are to find a safe dos…

This study looks at whether irreversible electroporation (IRE) can safely and effectively treat recurrent pelvic tumors in people who cannot have surgery, radiation, or other local treatments. IRE uses electrical pulses to destroy cancer cells without cutting or heating tissue. R…

This early-stage trial tests an experimental oral drug called NKT5097 in adults with advanced solid tumors, especially breast cancer. The drug works by breaking down two proteins that help cancer cells grow. Researchers want to find the safest dose and see if it can shrink tumors…

This early-phase study tests a new drug called STRO-004 in adults with advanced solid tumors that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in more patients, and combining STRO-004 with another d…

This early-phase trial is testing a new drug called DB-1303/BNT323 in people with advanced HER2-positive solid tumors that have not responded to standard treatments. The study aims to find a safe dose and see if the drug can shrink tumors. About 800 participants will take part ac…

This study tests a new drug called BNT329 in people with advanced solid tumors that have a specific marker (CA19-9). The main goals are to check safety and find the best dose. About 245 participants will take part. The drug works by targeting cancer cells and may help control tum…

This study tests two drugs, pembrolizumab and lenvatinib, in people with a type of uterine cancer that has come back after initial treatment. The cancer must be mismatch repair proficient, meaning it has a specific genetic feature. The goal is to see if this drug combination can …

This Phase 3 study tests whether a modified virus called Olvi-Vec, given with chemotherapy and bevacizumab, can help women with ovarian cancer that no longer responds to platinum drugs. About 186 participants will receive either the virus combination or standard chemotherapy. The…

This study tests a new drug called ivonescimab in 50 people with advanced endometrial or cervical cancer that has worsened after standard chemotherapy. The drug targets two proteins (PD1 and VEGF) to help the immune system fight cancer and block tumor blood supply. Researchers wi…

This early-stage trial tests a daily oral drug called CGT6297 in 90 adults with advanced solid tumors that have a specific mutation in the PIK3CA gene. The study has two parts: first, finding a safe dose, and then looking for signs that the drug shrinks tumors. It focuses on peop…

This early-phase trial tests a technique called PIPAC, which turns liquid chemotherapy into a fine mist sprayed directly into the abdomen during a minimally invasive surgery. It aims to see if this approach is safe and causes fewer side effects than standard chemotherapy. The stu…

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and …

This phase 3 trial is testing an immunotherapy drug called volrustomig in 800 women with high-risk locally advanced cervical cancer who have finished chemoradiation. The goal is to see if volrustomig can keep the cancer from coming back or improve survival compared to a placebo. …

This trial is testing whether a shorter, more intense course of radiation therapy can be a safe and effective option for people with high-risk endometrial cancer after surgery. Instead of the usual weeks of daily radiation, the study uses just five sessions of a higher dose, guid…

This phase III trial compares a shorter course of radiation therapy (hypofractionated) against the standard longer course for people with cervical cancer. Both groups also receive chemotherapy and brachytherapy. The goal is to see if the shorter schedule controls the cancer just …

This study tests a new drug called AZD5335, alone or with other cancer medicines, in people with advanced solid tumors like ovarian, lung, and endometrial cancers. The goal is to see if the drug is safe, tolerable, and shows signs of shrinking tumors. About 506 participants will …

This early-phase study tests a new drug, LNCB74, in people with advanced solid tumors (ovarian, breast, endometrial, bile duct, or lung cancer) that have not responded to standard treatments. The drug is designed to deliver a cancer-killing agent directly to tumor cells. The main…

This study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab. The goal is to see if the combination is safe and helps the immune system attack advanced solid tumors. About 132 people with various advanc…

This study is testing whether a shorter course of radiation therapy, given after surgery, can be as well-tolerated as the standard longer course for women with endometrial or cervical cancer. Instead of many small doses, the new approach uses five larger, precisely targeted doses…

This trial tests an experimental drug called STAR0602, which is designed to help the immune system attack cancer cells. It is being studied in people with advanced solid tumors that have not responded to standard treatments. The drug is given alone or combined with chemotherapy, …

This trial asks whether robot-assisted hysterectomy is as effective as traditional open surgery for treating early-stage cervical cancer. About 800 women with stage IB (excluding IB3) or IIA1 cervical cancer will be randomly assigned to one of the two surgical approaches. The mai…

This study tests a new drug, Rina-S, in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to see if Rina-S is safe and how well it works against cancers like ovarian, lung, and breast cancer. About 884 participants will receive the dru…

This trial compares two surgical approaches for early-stage cervical cancer: robotic-assisted surgery using the da Vinci system versus traditional open surgery. Researchers are asking whether the minimally invasive robotic method can match or improve upon open surgery in terms of…

This trial investigates whether salsalate, an anti-inflammatory drug, can reduce the elevated risk of cardiovascular disease seen in women with endometriosis. Researchers will measure blood vessel function and markers of inflammation in 24 women with endometriosis compared to hea…

This study tests whether a program of exercise and nutrition counseling helps women with ovarian or endometrial cancer stick with their chemotherapy plan. About 200 women who are about to start chemotherapy will be randomly assigned to either receive weekly coaching sessions on p…

This study tests whether adding the drug tarlatamab to standard radiation therapy is safe for people with cancers that have a protein called DLL3, including melanoma, lung cancer, and glioblastoma. About 30 adults with advanced or returning cancers will receive tarlatamab infusio…

This study tests a drug called enfortumab vedotin in up to 12 people with advanced endometrial (uterine) cancer that has worsened after standard treatments like immunotherapy. The drug works by targeting a protein on cancer cells to kill them. Researchers will measure how many pa…

This study tests whether giving two injections of a long-acting hormone (GnRH-a) before standard hormone therapy can improve pregnancy rates in women with deep infiltrating endometriosis undergoing their first frozen embryo transfer. The hormone pretreatment aims to suppress endo…

This study looks at whether surgically removing para-aortic lymph nodes before standard chemoradiation can improve disease-free survival in people with stage IIIC1 cervical cancer. About 510 participants will be randomly assigned to either standard treatment or surgery plus tailo…

This study tests a new drug called STX-478 in people with advanced solid tumors that have a specific genetic change (PI3Kα mutation). The trial has two phases: first, it tests STX-478 alone to find safe doses; then, it combines STX-478 with other cancer drugs like fulvestrant or …

This study tests whether a two-month hormone pretreatment (GnRH agonist plus letrozole) before standard frozen embryo transfer can improve live birth rates in women with adenomyosis. About 222 participants will be randomly assigned to either the new regimen or standard care. The …

This study follows 261 people with persistent, recurrent, or metastatic cervical cancer who are taking pembrolizumab (Keytruda) with or without bevacizumab (Avastin). Some participants may choose to stop pembrolizumab early if their tumor shrinks or disappears, while others conti…

This study is collecting real-world data from 150 women in Germany with advanced or recurrent endometrial cancer. Participants receive standard first-line treatment with chemotherapy plus durvalumab, followed by maintenance therapy with durvalumab alone or with olaparib. The goal…

This phase 2 trial tests the drug afatinib in 50 women with a rare, aggressive uterine cancer (HER2-positive uterine serous carcinoma) that has persisted or returned. Afatinib is a daily pill that blocks a protein driving cancer growth. The main goal is to see if it can keep the …

This early-stage trial explores whether injecting the immunotherapy drug nivolumab directly into lymph nodes before standard surgery is feasible and safe for people with cervical cancer. The study involves 12 participants and aims to see if this targeted approach can shrink tumor…

This study tests whether a shorter, 3-week course of radiation works as well as the standard 5-week course for women with locally advanced cervical cancer. About 396 women will be randomly assigned to one of the two schedules, both combined with chemotherapy. If the shorter sched…

This phase 2 trial is testing a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus standard chemotherapy before surgery in 103 women with locally advanced cervical cancer. The goal is to see if this approach can shrink tumors enough to allow less extensive…

This early-phase trial tests a new drug called AVA6103 in 174 people with advanced solid tumors (like pancreatic, stomach, or lung cancer) that have not responded to standard treatments. The drug is designed to activate only inside tumors, potentially killing cancer cells while r…

This study compares a new barbed suture (SYMMCORA) with a standard one (V-Loc) for closing the vaginal cuff after laparoscopic hysterectomy. The goal is to see if the new suture reduces stitching time without increasing complications. About 132 women having elective laparoscopic …

This phase 2 trial is testing two immunotherapy drugs, durvalumab and tremelimumab, alone or together, in 60 people with colorectal or endometrial cancer. The goal is to see if these drugs can shrink tumors or slow cancer growth. The study focuses on patients with different genet…

This study is testing Bearing nsPVA particles, used during a procedure called uterine artery embolization, to treat uterine fibroids in 100 women. The goal is to see if these particles safely block blood flow to fibroids, reducing symptoms like pain and heavy bleeding. Participan…

This study looks at 100 women with infertility to see how common chronic endometritis (a long-term inflammation of the womb lining) is and whether antibiotic treatment can improve their chances of getting pregnant and having a healthy baby. Participants will have a camera test an…

This early-phase trial is testing a new type of cell therapy called p95HER2.CAR-TECH2Me for people with advanced HER2-positive breast, gastric, or endometrial cancers that have spread. The treatment uses a patient's own immune cells, which are modified in a lab to better recogniz…

This early-stage trial tests two vaccines designed to help the immune system fight HPV16, a virus linked to cervical cancer. The study includes 30 women with persistent HPV16 infection and mild cervical cell changes (ASC-US or LSIL). Participants receive a DNA vaccine followed by…

This study is for adults with certain cancers (like breast, lung, or ovarian) that are in complete remission but have persistently low platelet counts from past chemotherapy. It tests whether adding a vitamin A derivative (ATRA) to a standard platelet-boosting drug works better t…

This study tests new treatments for endometrial cancer based on the genetic makeup of each person's tumor. About 1,615 participants will be assigned to one of four trials depending on their cancer's molecular profile. The goal is to see if these tailored therapies can prevent the…

This study tests a new treatment for people with solid tumors that have come back or not responded to standard care. The treatment uses a patient's own immune cells (T-cells) that are genetically modified in a lab to recognize and attack a protein called PRAME found on cancer cel…

This study tests if temporarily blocking the blood supply to the uterus and ovaries during minimally invasive fibroid surgery can reduce blood loss. About 120 women with large or numerous fibroids will be randomly assigned to receive the vessel-blocking technique or standard surg…

This pilot study tests a conservative management strategy for placenta accreta, a serious pregnancy complication where the placenta grows too deeply into the uterine wall. Instead of the standard treatment—a hysterectomy (removing the uterus) after a C-section—doctors will leave …

This phase II trial is testing whether the immunotherapy drug dostarlimab, alone or combined with bevacizumab, can control recurrent gynecological clear cell carcinoma better than standard chemotherapy. About 198 women with this rare cancer type will be randomly assigned to one o…

This phase 2 trial is testing two drugs, abemaciclib and letrozole, in 100 people with rare estrogen receptor-positive ovarian cancers (low grade serous carcinoma or granulosa cell tumors). The goal is to see if the combination can shrink tumors and control the disease. Participa…

This study tests if a once-weekly injection of somatrogon works as well as a daily growth hormone shot for children with short stature. It includes 254 children born small for their age or with no clear cause for their short height. The goal is to see if the weekly option can imp…

Stanford University is testing the da Vinci Xi robot for various surgeries in children aged 6-21. The study will enroll 250 participants to check if the robot is safe and works well. The goal is to see if robotic surgery can be a good option for kids needing procedures like gallb…

This phase 2 trial is testing valemetostat, a daily pill, in 900 adults with advanced solid tumors that have specific gene changes (like SMARCB1 or ARID1A). The drug works by blocking EZH1/2 enzymes to reactivate genes that normally protect against cancer. The main goal is to see…

This study looks at whether surgically removing deep endometriosis from the bowel before IVF improves pregnancy rates compared to IVF alone. It includes 120 women with infertility and pain from deep endometriosis. Participants are randomly assigned to either have surgery then IVF…

This early-stage trial tests a new treatment called THEO-260, a virus designed to infect and destroy cancer cells. It is given directly into the abdomen to 18 people with advanced ovarian cancer that no longer responds to platinum chemotherapy. The main goals are to find a safe d…

This phase 2 trial is testing whether giving the drug niraparib again after surgery can help women with ovarian cancer whose disease has come back in just a few spots. About 30 participants will take niraparib pills daily until their cancer grows or side effects become too much. …

This Phase 2 trial tests whether trastuzumab deruxtecan (T-DXd), a targeted antibody-drug conjugate, works better than standard chemotherapy for recurrent ovarian cancer that has stopped responding to PARP inhibitors. About 116 participants whose tumors express the HER2 protein w…

This study looks at two less invasive options—radiofrequency ablation (RFA) and uterine artery embolization (UAE)—for women with heavy bleeding due to adenomyosis who are eligible for hysterectomy. The goal is to see if these treatments can reduce bleeding and pain as well as hys…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control the tumors when other treatments have stopped working. Up to 28 adults will receive treatment for up to 12 months, an…

This study tests a new treatment called THEO-260, a virus designed to attack cancer cells, in people with advanced ovarian cancer that no longer responds to platinum chemotherapy. About 44 participants will receive different doses of the virus through an IV to find a safe dose an…

This study is for women with advanced ovarian cancer who have had complete surgery and chemotherapy. It compares two maintenance treatments: niraparib alone versus niraparib plus bevacizumab. The goal is to see which approach better delays cancer progression. About 390 participan…

This early-phase study tests a new drug called azenosertib (ZN-c3) combined with standard chemotherapy or bevacizumab in people with ovarian, peritoneal, or fallopian tube cancer that has stopped responding to platinum-based treatment. About 172 participants will receive differen…

This early-stage trial is testing a new treatment called VET3-TGI, a virus designed to infect and destroy cancer cells. It is being given alone or with the immunotherapy drug atezolizumab to 60 people with advanced solid tumors that have not responded to standard treatments. The …

This study tests whether combining targeted drugs with the immunotherapy atezolizumab can shrink tumors or slow cancer growth in people with endometrial cancer that has come back or persists. About 148 participants whose cancer has progressed after at least one prior treatment wi…

This study tests whether injecting a lab-made collagen into the uterus, along with daily hormone pills, can help shrink early-stage endometrial cancer or precancerous growths. The goal is to preserve fertility in women aged 45 or younger. Thirty participants will either receive t…

This study compares a newer, less invasive laparoscopic hysterectomy (with special tumor-free techniques) to the standard open abdominal surgery for stage IB2 cervical cancer. About 524 women will be randomly assigned to one of the two surgeries. The main goal is to see if the la…

This early-phase study tests a new drug called 177LuBetaBart in people with advanced solid tumors that have stopped responding to standard treatments. The drug is a radioactive antibody designed to seek out and destroy cancer cells. The study will enroll about 61 participants and…

This study compares a shorter, higher-dose radiation schedule (hypofractionated radiotherapy) to the standard longer course for women with locally advanced cervical cancer in Uganda. About 278 participants will receive either the shorter or standard radiation, plus chemotherapy a…

This early-stage trial is testing a new daily oral medication called ETX-19477 in about 120 adults with advanced solid tumors, including breast, ovarian, prostate, and other cancers. The drug blocks a protein called PARG to interfere with cancer cells' ability to repair themselve…

This study looks at whether giving platelet transfusions only when levels are very low can help extremely premature babies (born at 23-26 weeks) survive without major bleeding. About 2,400 infants will be randomly assigned to a lower or higher transfusion trigger. The goal is to …

This study compares three surgical treatments for endometriomas (ovarian cysts from endometriosis) in 332 women aged 18-43 who want to become pregnant. Participants are randomly assigned to cystectomy, plasma vaporization, or sclerotherapy. The main goal is to see which approach …

This study aims to improve fertility-sparing treatment for young women (ages 18-45) with endometrial cancer by tailoring therapy to the tumor's genetic profile. Participants will receive either hormone therapy (progestins) or a combination with an immunotherapy drug (sintilimab),…

This study tests whether a single, extremely high dose of radiation, guided by advanced MRI technology, can control liver tumors that have spread from other cancers better than the usual high dose. About 114 adults with up to 3 liver metastases will be randomly assigned to receiv…

This program offers early access to the investigational drug selinexor for people with certain advanced cancers, such as multiple myeloma, lymphoma, sarcoma, and others, who have no other treatment options. Patients must not qualify for any ongoing clinical trial and must have ex…

This phase 2 trial is testing whether adding a precise radiation boost to standard treatment can shrink large cervical tumors more effectively. Seventeen participants with bulky squamous cell carcinoma will receive external radiation plus a targeted boost, followed by internal br…

This phase 2 trial is testing a shorter course of radiation therapy (hypofractionated IMRT) given alongside chemotherapy (cisplatin) for cervical cancer. The goal is to see if this approach can reduce the overall treatment time from the usual 7-8 weeks while still controlling the…

This study looks at whether giving the 9vHPV (Gardasil-9) vaccine to women who already have HPV16 or 18 can reduce the virus's ability to infect others. Researchers will measure viral activity in cervical, anal, and oral samples before and after vaccination. The goal is to see if…

This study tests whether a daily dose of pravastatin, a common heart medication, can safely prolong pregnancy in women diagnosed with severe early-onset preeclampsia or fetal growth restriction. The trial will include 154 pregnant women between 24 and 30 weeks of gestation, rando…

This study tests whether a same-day HPV screening and treatment approach can help prevent cervical cancer in women living with HIV in the Dominican Republic. 600 women will be randomly assigned to either the new same-day method or standard care. The goal is to see if more women c…

This study looks at whether women with a rare, slow-growing uterine cancer (low-grade endometrial stromal sarcoma) can safely stop taking their hormone-blocking pills (aromatase inhibitors) after long-term use. Half the participants will stop the pills and half will continue, and…

This study tests a less invasive weight-loss procedure called endoscopic suture gastroplasty (ESG) in 74 obese women who have had curative treatment for endometrial cancer. The goal is to see if ESG is safe and effective for helping these women lose weight, since obesity raises t…

This early-phase study tests a new radioactive drug, [177Lu]Lu-AKIR001, in 15 adults with advanced solid tumors (like thyroid, head and neck, cervical, vulvar, or lung cancer) that have stopped responding to standard treatments. The main goal is to check the drug's safety and sid…

This study tests whether taking a daily targeted therapy pill (olaparib) for one year after standard chemoradiation can prevent endometrial cancer from coming back in patients with a specific genetic change (p53 abnormal). About 554 participants will be randomly assigned to recei…

This study tests whether treating asymptomatic bacteriuria (a bladder infection with no symptoms) in pregnant women can reduce the number of preterm births, stillbirths, and underweight babies. Over 1,100 pregnant women in seven low- and middle-income countries will receive eithe…

This study looks at whether giving a GnRH agonist before a frozen embryo transfer can help women with endometriosis or adenomyosis get pregnant. About 180 women aged 18 to 36 will be randomly assigned to receive either standard hormone support or standard support plus one or two …

This study compares two antibiotic treatments for acute kidney infection in children aged 1 month to 3 years. One group gets 3 days of IV antibiotics only, while the other gets 3 days IV followed by 7 days of oral antibiotics. The goal is to see if the shorter course works just a…

This study tests a new tablet called ABP1011T in people with advanced solid tumors, including small cell lung cancer and others like esophageal or bladder cancer. Participants take one pill daily in 21-day cycles. The goal is to see if the drug can shrink tumors and how safe it i…

This study is testing a simple blood test that looks for tumor DNA from HPV-related cervical and anal cancers after radiation treatment. The goal is to see if this test can replace expensive imaging scans and help doctors find early signs of cancer returning. If the test is posit…

This early-stage trial tests a new drug called ONM-501, which is injected directly into tumors, either alone or with the immunotherapy cemiplimab (Libtayo). The study includes 168 adults with advanced solid tumors or lymphomas that have not responded to standard treatments. The m…

This study looks at a treatment for large ovarian cysts caused by endometriosis (6 cm or bigger). The approach involves draining the cyst during a keyhole surgery and then using hormone therapy to lower the chance of the cyst coming back and to protect the ovaries. The goal is to…

This phase 2 trial tests zanidatamab, a drug that targets cancer cells with a HER2 gene alteration, in 105 adults with advanced lung, endometrial, colorectal, head & neck, or sarcoma cancers. Participants receive the drug every 3 weeks, and doctors monitor tumor shrinkage and sid…

This study tests whether giving patients a special nutritional drink (immunonutrition) before bladder removal surgery can reduce complications like infections. About 232 adults having open cystectomy for various bladder conditions will be randomly assigned to receive the drink or…

This early-phase study tests a new treatment called GC203 TIL for people with advanced solid tumors (cancers in organs like the breast, lung, or gut) that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to bet…

This study compares two surgical methods for treating ovarian endometriomas (cysts caused by endometriosis): standard cystectomy (removing the cyst wall) and argon plasma coagulation (using a gas-based tool to destroy the cyst lining). The goal is to see which method better prese…

This trial tests atezolizumab, a drug already approved for several cancers, in people with rare cancers that have high tumor mutational burden (TMB) or microsatellite instability (MSI). The goal is to see if the drug can shrink tumors or stop them from growing for at least 24 wee…

This study tests if injecting alcohol into endometriosis-related ovarian cysts (sclerotherapy) can better preserve egg supply and reduce cyst return compared to standard surgical removal. Sixty women aged 18-40 with cysts at least 2 cm will be randomly assigned to one of the two …

This study compares two approaches for women under 39 with advanced endometriosis who want to get pregnant: having surgery to remove endometriosis lesions before IVF, or going straight to IVF. The goal is to see which leads to more live births within three years. The trial will e…

This study tests whether a 24-week digital wellness platform, combined with one-on-one online sessions with a dietitian, exercise pro, and therapist, can help endometrial cancer survivors lose inches around their waist and improve their health. About 148 survivors who are overwei…

This study tests whether a combination of two drugs, VS-6766 and defactinib, can shrink or control certain gynecological cancers that have come back. It includes women with endometrioid, ovarian, or cervical cancers that have specific gene changes (RAS, BRAF, or NF1). The goal is…

This study compares a newer radiation technique called SABR with standard brachytherapy for treating locally advanced cervical cancer. About 84 women will receive either SABR or brachytherapy after initial chemo-radiation. The goal is to see if SABR is as safe and effective, whic…

This Phase 3 trial is testing whether adding letrozole (a hormone-blocking drug) to standard maintenance therapy can delay cancer recurrence in people with estrogen-receptor-positive ovarian cancer. About 540 participants who have completed initial surgery and chemotherapy will r…

This study tests whether taking misoprostol before myomectomy (surgery to remove uterine fibroids) can reduce blood loss during the operation. 80 women aged 18-43 with symptomatic fibroids will receive either misoprostol or a placebo before surgery. The goal is to see if this sim…

This study follows 140 patients who previously received High-Intensity Focused Ultrasound (HIFU) for rectal endometriosis. Researchers want to see if the treatment's benefits—like pain relief and better quality of life—hold up over the long term. Participants fill out online ques…

This phase 3 trial tests whether a plant-based supplement (Indinol Forto, made from indole-3-carbinol) works as well as a standard hormone drug (Visanne, dienogest) for reducing pelvic pain in endometriosis. About 290 women aged 18-45 with surgically confirmed endometriosis will …

This study compares two types of minimally invasive surgery for early-stage endometrial cancer: robot-assisted laparoscopy and conventional laparoscopy. About 1,680 patients will be randomly assigned to one of the two procedures. The goal is to see which approach offers better va…

This phase 2 trial is testing whether giving a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) along with chemotherapy before surgery can help shrink tumors in people with locally advanced cervical cancer. The study will enroll 43 participants and measure ho…

Researchers at Semmelweis University are building and testing artificial intelligence algorithms that read standardized transvaginal ultrasound images. The study includes women aged 18 to 45 who have suspected endometriosis or adenomyosis, a confirmed uterine mass scheduled for s…

This study tests whether a smartphone-based AI ultrasound, operated by health workers with minimal training, can accurately estimate gestational age, detect placenta position, and identify fetal presentation in pregnant women in rural Democratic Republic of the Congo. The goal is…

The ORACLE study watches people who have finished treatment for early-stage solid tumors, such as lung, breast, colon, and pancreatic cancers. Researchers want to see if a blood test called Guardant Reveal can find tiny traces of tumor DNA that might signal the cancer is coming b…

Preeclampsia is a serious high blood pressure condition that can develop during pregnancy and is a leading cause of death for mothers and babies in Africa. Doctors struggle to predict which women with high blood pressure will become severely ill because current tests are not accu…

This trial tests whether a simple blood test can help detect and monitor cervical cancer. Researchers will analyze tiny DNA fragments and particles in the blood, called cell-free DNA and extracellular vesicles, to see if they act as early warning signs. The study involves 100 wom…

This study is collecting vaginal fluid samples from 4,200 people to develop a new test for endometrial cancer. Participants include those with abnormal uterine bleeding or a recent endometrial cancer diagnosis. The goal is to find biomarkers that could lead to a simple, non-invas…

This study is working on a new, non-invasive test to help rule out uterine cancer in women aged 45 and older who have abnormal bleeding. Researchers will collect samples from 4,500 women to see how well the test detects cancer and identifies benign cases. If successful, it could …

This study tests a low-cost HPV test that can be done in one visit, so women get results and treatment on the same day. It aims to reduce the number of women lost to follow-up in cervical cancer screening programs. The study will enroll 1,000 women in remote areas of El Salvador.

This study evaluates a rapid test called Methylscape that measures DNA methylation patterns in body fluids like blood, urine, or saliva. The goal is to see if it can detect a cancer signal and even predict where the cancer started, using a single sample. Researchers will compare …

This trial tests whether applying vaginal estrogen before a colposcopy helps doctors see the cervix more clearly in women aged 50 and older. As women age, the area where precancerous changes occur can become harder to view, which may lead to missed diagnoses or repeat procedures.…

This study explores whether a tampon can collect DNA samples from the vagina to detect endometrial and ovarian cancer early. Researchers will compare tampon samples with tissue and blood from 1,500 women undergoing surgery. The goal is to develop a simple, non-invasive screening …

This study is testing whether a special menstrual pad, called the Q-Pad, can accurately detect high-risk HPV from menstrual blood collected at home. About 450 people who need a colposcopy after an abnormal Pap or HPV test will use the pad during their period and mail it to a lab.…

This study evaluates whether an HPV DNA test can more accurately detect pre-cancerous cervical changes than standard Pap smears in 1,500 women in South Africa, including those with and without HIV. Participants undergo HPV testing, followed by colposcopy and biopsy if needed. The…

This trial investigates whether advanced MRI scans can better detect placenta adhesion abnormalities (PAA) in pregnant women between 30 and 38 weeks. PAA occurs when the placenta grows too deeply into the uterine wall, raising risks of severe bleeding and emergency hysterectomy d…

This study looks at whether a menstrual cup can collect enough uterine tissue to screen for endometrial cancer, especially in women with Lynch syndrome who are at higher risk. About 25 participants will use a menstrual cup at home and also have a standard biopsy, then compare the…

This study is testing a new, affordable AI system to screen for cervical cancer in low- and middle-income countries. The AI analyzes urine samples and cervical images to detect high-risk HPV and precancerous changes. About 3,200 unscreened women aged 25-49 in Zimbabwe will take p…

This study compares two ways to offer cervical cancer screening to women living with HIV: standard clinic-based screening versus adding community outreach where health workers provide HPV self-collection kits at home or in community settings. About 7,600 women across multiple cli…

This study is testing whether a special full-body PET/CT scan can spot endometriosis without needing surgery. Up to 30 women with suspected endometriosis will get two scans using different tracers that highlight bleeding and scarring. The scan results will be compared with findin…

This study follows 20,000 women who take a new saliva test (Endotest) to diagnose endometriosis. Researchers want to see how the test result—positive or negative—affects their quality of life, emotions, and care decisions. Participants fill out questionnaires and share medical da…

This study is testing a new blood test that looks at RNA (genetic material) to quickly tell if a person with belly pain has an infection inside the abdomen, like appendicitis or diverticulitis. About 1,000 adults and children over age 7 with abdominal pain will give a blood sampl…

This study is testing whether a simple urine sample can be used instead of a cervical swab to screen for HPV, the virus that causes most cervical cancers. The researchers will collect first-void urine from 350 women aged 30–65 using a special device and compare the results to the…

This study aims to develop a screening test that uses a vaginal swab and blood sample to find DNA markers for endometrial, ovarian, and cervical cancers. Researchers at Mayo Clinic will enroll over 3,000 women to see if the test can accurately detect these cancers at an early sta…

This study aims to find markers in menstrual blood that can diagnose endometriosis, a painful condition affecting many women. Researchers will compare menstrual blood from 250 women with and without endometriosis, and also look at changes after surgery. If successful, this could …

This study aims to find a gentler way to detect uterine cancer early in people with abnormal bleeding. Instead of relying only on a biopsy, researchers will use a health questionnaire and a self-collected vaginal swab to look for cancer-related genetic changes and microbiome patt…

This study is testing whether a self-administered Pap smear is as accurate as the traditional one done by a healthcare provider. Researchers will recruit 250 women in rural Alabama who need routine cervical cancer screening. Each woman will do a self-collected sample right before…

This study looks at whether the things people buy at stores—like pain relievers or digestive aids—could be early warning signs of cancer. Researchers will compare the shopping habits of 2900 people, some diagnosed with cancer and some not, to see if certain purchases happen more …

This study is testing whether a special PET scan called 18F-FES PET/CT can find endometriosis lesions more accurately than standard MRI. The scan measures estrogen receptors in the lesions, which may help doctors understand pain levels and guide treatment. About 20 women with end…

This study is testing whether giving women a simple self-sampling kit to use at home can increase the number of women who get screened for cervical cancer. The trial will enroll 15,000 women in Czech Republic, especially those who haven't had a Pap smear in over 3 years. Particip…

This study is looking at whether a protein called L-PGDS can be used to diagnose adenomyosis, a condition where uterine tissue grows into the muscle wall, causing pain and heavy bleeding. Researchers will measure L-PGDS levels in vaginal swabs, blood, and urine from 60 women with…

This study tests a new device called the Calla introducer for cervical cancer screening. Researchers want to see if women prefer it over the standard speculum used during Pap smears. About 305 healthy women aged 21-65 will participate. The goal is to improve comfort and screening…

This study tests whether a specific ultrasound measurement can reliably detect superficial endometriosis on the uterosacral ligaments. Researchers will compare ultrasound findings with laparoscopic surgery results in 64 women undergoing gynecological surgery. If a clear cutoff th…

This study is testing a new, low-cost screening tool for cervical cancer that uses artificial intelligence to analyze digital images of the cervix. It does not require a lab and can be used at the point of care. The goal is to see if this AI tool can accurately detect precancerou…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This early-stage study tests whether a dye called CYTALUX (pafolacianine) can make endometrial cancer cells glow under a special camera during surgery. The goal is to help surgeons find and remove all cancer. Ten adults with endometrial cancer who are already scheduled for surger…

This study is testing how well two types of 3D ultrasound can detect a uterine septum (a wall inside the uterus) compared to MRI. About 145 women aged 18-45 with a suspected septum will get both an MRI and the ultrasound exams. The goal is to see if the ultrasounds are as good as…

This study compares two methods—OSNA and ultrastaging—for finding cancer in lymph nodes removed during surgery for early-stage endometrial cancer. About 1,900 women will be randomly assigned to one of the two detection techniques. The goal is to see which method finds more cancer…

Researchers are testing whether giving the antibiotic zinacef during labor lowers infections for women with meconium-stained amniotic fluid at term and for their newborns. The trial enrolls 182 women with a single full-term pregnancy and meconium in the fluid. Half receive zinace…

Researchers at Florida A&M University are testing whether a virtual educational session led by a lay health advisor, called a promotora, helps Hispanic women who are behind on cervical cancer screening get tested. The trial enrolls about 160 Hispanic women ages 21 to 65 who have …

This phase 2 trial tests whether cryocompression therapy, alone or combined with the drug cilostazol, can prevent peripheral neuropathy in people receiving paclitaxel for gynecologic cancers. Peripheral neuropathy causes numbness, pain, or tingling in the hands and feet and is a …

This trial tests whether placing a special gel inside the uterus after fibroid removal surgery can prevent the formation of scar tissue (adhesions) that may harm fertility. Women aged 18 to 45 who are scheduled for laparoscopic or abdominal myomectomy and have no pre-existing ute…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests a program called SAKHI HPV for women in India who have both HPV and HIV. The program provides support from community health workers, group sessions, and nutrition education to help women stay healthy and reduce their risk of cervical cancer. Researchers will comp…

This study tests whether taking green tea extract (EGCG) and vitamin D3 daily can prevent uterine fibroids from growing back after surgical removal. About 240 women who have had fibroid surgery will receive either the supplements or a placebo. The goal is to see if this simple co…

This study tests whether taking 150 mg of aspirin daily, starting before 20 weeks of pregnancy, can prevent serious problems like preeclampsia, poor fetal growth, placental abruption, preterm birth, and death in pregnant women with chronic high blood pressure. About 500 women wil…

This study tests whether at-home HPV self-sampling (using urine or a vaginal swab) can help more people get screened for cervical cancer compared to the traditional in-clinic Pap smear. About 735 Latinx individuals aged 30-65 who haven't had a Pap test in at least three years wil…

This study tests whether a general practitioner's encouragement can increase the number of women who get screened for cervical cancer. Over 11,000 women aged 25-65 in France who are behind on screening will be involved. The goal is to see if a simple conversation with their famil…

This study checks how well the HPV vaccine prevents cervical HPV infection in women in Sikkim, India, about 7 years after the vaccine was introduced. Researchers will collect cervical samples from 5,500 married women aged 18-22 and compare infection rates to those before vaccinat…

This study offers free genetic testing to 5,000 women, trans men, and non-binary people with female reproductive organs, regardless of family history. The goal is to find hidden gene changes that raise the risk of breast, ovarian, bowel, and womb cancers. Participants use a smart…

This study looks at whether a structured ultrasound program (OxGRIP) can help detect babies that are not growing well in the womb, which is a major risk factor for stillbirth. The program adds a routine scan at 36 weeks and extra scans for at-risk women. Researchers will compare …

This study in Honduras tests a new way to prevent cervical cancer using a self-collected HPV test that gives results in under an hour, combined with AI-powered imaging. 5,000 women will participate to see if this same-day screening-and-treatment approach is accurate, feasible, an…

This study looks at whether adding pelvic floor physical therapy before standard radiation treatment can help reduce pain and sexual problems in women with cervical, vaginal, vulvar, uterine, or anal cancer. About 20 participants will receive education on using a vaginal dilator …

This study is testing a precise type of radiation (proton beam) given to the pelvis after surgery for cervical, uterine, or endometrial cancer. The goal is to see if it causes fewer bowel side effects than standard radiation. About 25 adults who need pelvic radiation after surger…

This study tests if a newer, shorter course of radiation therapy (MH-ART) is as good as the standard longer course (CF-IMRT) for women who have had surgery for cervical or endometrial cancer. The goal is to see if the new approach causes fewer side effects and improves quality of…

Cancer treatment often leaves patients with a deep, lasting tiredness that few treatments can fix. Researchers are testing whether guarana, a caffeine-rich Amazonian plant, can reduce that fatigue and improve daily life. The study gives 60 people with breast, lung, colorectal, ce…

Researchers are testing whether a quadratus lumborum nerve block reduces pain after laparoscopic myomectomy, a surgery to remove uterine fibroids while keeping the uterus. The block is a temporary anesthetic injection into a lower back muscle. In this double-blind, randomized tri…

This study tests whether ultrasound-guided alcohol sclerotherapy can reduce pelvic pain and improve quality of life in women aged 18-45 with ovarian endometriomas. Participants are randomly assigned to receive the procedure or no treatment (expectant management) and are followed …

This study tests a new drug called vipoglanstat to see if it can reduce pelvic pain in people with endometriosis. About 190 women aged 18 to 44 with moderate to severe pain will take either the drug or a placebo for four months. The goal is to find a better treatment option for t…

Researchers at Mount Sinai are testing whether a reinforcement learning system can deliver personalized daily exercise recommendations to people with chronic pelvic pain. The study enrolls 45 adults who receive alternating standard and AI-generated exercise advice over four two-w…

This trial tests whether preparing the cervix with medication before office hysteroscopy helps postmenopausal women have a more successful and less painful procedure. Participants are randomly assigned to receive either oral misoprostol, vaginal estrogen for 7 or 14 days, or no p…

This study looks at possible eye-related side effects in people with cervical cancer that has returned or spread, who are being treated with the drug TIVDAK. About 100 participants will receive TIVDAK every 3 weeks and undergo regular eye exams before, during, and after treatment…

This study looks at whether electroacupuncture (a type of acupuncture with mild electric pulses) can help women who have trouble urinating after surgery for cervical cancer. About 208 participants will receive either real or fake electroacupuncture alongside standard care. The ma…

This pilot study tests whether a device called Flyte can help improve urinary incontinence in women who had radiation therapy for endometrial or cervical cancer. The Flyte device is used at home and delivers gentle vibrations while the user does Kegel exercises. The study will ch…

This study tests whether the drug misoprostol, given before a cervical exam, can help doctors see the cervix more clearly. 420 women with a hard-to-examine cervix (called Type 3 transformation zone) will receive either misoprostol or a placebo. The goal is to see if the drug make…

This study tests whether a procedure called ovarian and pelvic vein embolization can reduce chronic pelvic pain in women with pelvic varicose veins. Forty women with severe pain lasting over six months will be randomly assigned to either the embolization procedure or a diagnostic…

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This trial tests whether a three-day low-residue diet and deeper muscle relaxation, alone or together, can improve the surgical view during vNOTES hysterectomy (a scarless procedure through the vagina). The study involves 160 women having hysterectomy for non-cancer conditions. R…

This trial investigates whether a minimally invasive procedure called endovascular embolization can relieve chronic pelvic pain in women with pelvic congestion syndrome. The study will enroll 30 women who have had pelvic pain for more than six months and have imaging evidence of …

This trial tests whether a custom-formulated, high-CBD hemp product can reduce pain in women with endometriosis, adenomyosis, or chronic pelvic inflammatory disease. Over 7 days, participants receive either the CBD product or a placebo. Researchers will measure how the body proce…

This study tests whether the drug letrozole can improve symptoms and shrink fibroids in women with uterine fibroids. 140 participants will receive either letrozole or a placebo daily for 12 weeks. The main goal is to see if letrozole reduces symptom severity and improves quality …

This study tests whether up to 9 sessions of electroacupuncture can reduce pelvic pain in women with suspected endometriosis who are scheduled for diagnostic surgery. 38 women aged 18-45 with moderate to severe pain will be enrolled. The goal is to see if this treatment can impro…

This study tests a new way to deliver radiation therapy for endometrial cancer using daily MRI scans to guide the beam. The goal is to give a higher dose of radiation to the tumor while sparing nearby organs like the bowel and bladder. Thirty participants will receive 15 sessions…

This study tests whether a specialized kit helps women with endometriosis manage pain during sex. The kit includes a guidebook, a tracking app, a TENS device, lubricants, and supplements. One hundred women aged 18 to 45 with confirmed endometriosis and sexual pain will either use…

This study tests a 12-week digital program called Samphire Guided Care for people with menstrual or pelvic health conditions like PMS, endometriosis, or menopause. The program combines a wearable device that gently stimulates the brain, coaching, and symptom tracking to see if it…

This study tests whether infusing platelet-rich plasma (PRP) into the uterus can thicken the uterine lining and improve pregnancy success in women with infertility who have had failed IVF cycles due to a thin lining. About 62 women will receive either PRP or a placebo during a fr…

This study tests whether injecting the local anesthetic bupivacaine into the small surgical cuts and the vaginal cuff at the end of a laparoscopic hysterectomy can lower postoperative pain. 120 women having the surgery for non-cancer reasons will be randomly assigned to receive t…

This study tests if whole-body cryotherapy (standing in a -120°C chamber for 3 minutes) can safely reduce pain and improve quality of life in people with endometriosis. Thirty participants with chronic pelvic pain will attend 5 sessions over 4 weeks. Researchers will measure pain…

This study tests whether a high-protein nutrition plan combined with resistance exercises, started weeks before surgery and continued for 24 weeks after, can help older adults with cancer preserve their physical function. The trial enrolls Veterans aged 55 and older with certain …

This study tests whether a physiotherapy program that combines gentle exercise with pain education can reduce pain and improve daily life for women with endometriosis. About 62 women will take part, with half receiving the combined program and half receiving pain education alone.…

This study is testing whether a shorter course of pelvic radiation after surgery works as well as the standard longer schedule for people with cervical or endometrial cancer. The shorter schedule means fewer hospital visits and less time in treatment. About 120 participants will …

This study tests a new surgical technique called intra-operative dual laparoscopy and neo-rectoscopy (IDLnR) for treating bowel endometriosis. Researchers will compare it to standard laparoscopic surgery in 192 women aged 18-55. The goal is to see if the new method leads to bette…

This study is testing whether a low-FODMAP diet can reduce pain and improve quality of life in women with endometriosis who also have gut symptoms like bloating and nausea. Researchers will compare the diet to standard care in 150 women aged 18-45. The goal is to see if changing …

This study tests whether Reiki therapy can reduce anxiety and pain in people receiving brachytherapy for gynecologic cancers. 70 participants will either receive Reiki or standard care during their treatment. Researchers will measure changes in anxiety, pain, and mood using quest…

This study is testing whether a 21-day spa program—including mineral water baths, exercise, and diet—can improve kidney function and reduce symptoms in 150 adults aged 40-70 with chronic kidney or urinary tract diseases. Participants receive standard spa care at a resort in the C…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can reduce pelvic pain in women with endometriosis. The trial will include 64 women who have moderate to severe pain and are waiting for surgery. Half will receive 40 HBOT sessions…

This study looks at whether people with certain cancers prefer getting their immune therapy as a shot under the skin (subcutaneous) or through a needle in a vein (intravenous). About 880 adults who are already eligible for standard treatments like nivolumab or pembrolizumab will …

This study tests whether a small electrical device (TENS) can reduce pelvic pain in women with endometriosis or adenomyosis. 92 women on stable hormone therapy will use the device for 45 minutes daily over 4 weeks, rating their pain on a scale. The goal is to see if the device lo…

This study looks at whether alternate day fasting (eating very little every other day) before chemotherapy can help reduce side effects and improve quality of life for women with ovarian, endometrial, or uterine cancer. About 30 women who have had surgery and are about to start c…

This study tests whether a program of exercise, nutrition advice, and mental support before surgery helps gynecological cancer patients recover faster and feel better. About 64 women with ovarian or endometrial cancer will be randomly assigned to either standard care or the preha…

This study tests a new way of giving radiation for cervical cancer. Instead of using the same plan for weeks, an AI adjusts the radiation daily based on the tumor's position, and weekly MRI scans help guide it. The goal is to reduce side effects like bladder and bowel problems. A…

This study tests whether a food supplement called Doliral can improve quality of life and reduce pelvic pain in women with endometriosis. About 60 women with confirmed endometriosis and ongoing pelvic pain will take either Doliral or a placebo for 12 weeks. Researchers will track…

This study explores whether acupuncture can reduce nerve pain and numbness caused by chemotherapy in people with gynecologic, urologic, or rectal cancers. About 75 participants will be randomly assigned to receive real acupuncture, sham acupuncture, or usual care for 6 weeks. The…

This study compares a fast, 1-week radiation treatment to a standard 6-8 week schedule for reducing pain in people with advanced cervical cancer that cannot be cured. The goal is to see if the shorter schedule provides similar or better pain relief. The trial is recruiting 230 pa…

This study compares robot-assisted hysterectomy to standard laparoscopic surgery for women with deep endometriosis and adenomyosis. The goal is to see which approach leads to fewer complications and better quality of life. 224 participants will be randomly assigned to one of the …

This study tests small hormone implants placed under the skin to relieve menopause symptoms like hot flashes, low mood, and sexual problems. It includes 140 women with natural menopause, early ovarian failure, or menopause from cervical cancer treatment. Researchers will check ho…

This study tests an 8-week group program called PEEPS for people with endometriosis-related chronic pelvic pain. Participants attend weekly sessions with others and get education and support, in addition to their usual care. The goal is to see if this approach reduces how much pa…

This study tests whether a series of workshops led by different health experts, plus regular nurse phone calls, can improve quality of life for women with endometriosis. About 260 women with confirmed endometriosis and chronic pelvic pain will take part. The program focuses on ed…

This study tests whether a wearable device called NettleEndo, which delivers mild electrical stimulation to the brain, can reduce chronic pelvic pain in women with endometriosis. About 120 women will use the device at home for 20 minutes a day, five days a week, for 12 weeks. Hal…

This study compares a shorter course of vaginal cuff brachytherapy (internal radiation) to the standard longer course for people with stage I-II endometrial cancer. The main goal is to see if the shorter treatment improves quality of life and reduces financial burden, while still…

This study tests if a non-invasive device that stimulates a nerve in the ear can reduce chronic pelvic pain caused by endometriosis. The device is thought to lower inflammation and change brain chemicals that affect pain. Researchers will enroll 72 women with endometriosis to see…

This study tests whether a pre-surgery program of exercise and a dietary supplement called Ocoxin can improve recovery for 100 women undergoing surgery for gynecologic cancers like endometrial, ovarian, or cervical cancer. Participants will follow an enhanced recovery protocol (E…

This study looks at whether using the Headspace mindfulness app before surgery or chemoradiation can help people with endometrial or cervical cancer use fewer opioid painkillers. About 120 participants will be randomly assigned to use the app or not. The goal is to see if mindful…

This trial tests a new type of radiation therapy for cervical cancer that adjusts the beam daily based on the patient's anatomy. The goal is to reduce acute bowel side effects like diarrhea and urgency. About 125 patients with advanced cervical cancer will receive this treatment,…

This pilot study tests whether using a dye called indocyanine green to highlight the ureters during endometriosis surgery causes less pain and fewer side effects than the standard method of placing temporary plastic stents. The trial will recruit 70 women aged 18–50 who are sched…

This large screening trial enrolls up to 2,900 people with advanced solid tumors that have spread or not responded to standard treatment. Researchers use genetic tests on tumor samples to find specific mutations, then assign patients to treatment trials testing drug combinations …

This study talks to women with and without endometrial cancer to learn what they know about risk factors and prevention options. Researchers hope to create a tool that helps women make informed decisions. About 45 women will take part at MD Anderson Cancer Center.

This study looks at whether removing only a few key lymph nodes (sentinel node biopsy) is better than removing no nodes at all in women with early-stage endometrial cancer. The goal is to see if this approach helps women return to normal activities faster and does not increase th…

This study is creating a registry of 750 people with a rare and aggressive form of cervical cancer called neuroendocrine carcinoma. Researchers will collect information from medical records to learn more about the disease, how it is treated, and what happens to patients over time…

Researchers are studying atypical endometriosis, a form of the condition whose cells look unusual under the microscope and may sometimes precede ovarian cancer. The study enrolls about 200 adults scheduled for endometriosis surgery or surgery for suspected ovarian or endometrial …

This observational study in Vietnam looks at archived tumor samples from patients with several solid cancers, including liver, colorectal, gastric, breast, lung, endometrial, melanoma, and pancreatic cancer. Researchers will measure the presence of two proteins, ENPP1/cGAS and FA…

This study looks at the genetic makeup of advanced endometrial cancer in 500 women in Russia. Researchers will test tumor samples for specific gene changes to see how common they are and what treatments patients receive. The goal is to gather information, not to test a new treatm…

This study will test tumor samples from 350 adults with gynecological cancers (endometrial, ovarian, cervical, vulvar, and vaginal) to see how often they have high levels of the HER2 protein. Researchers will use two standard lab tests to measure HER2. The goal is to learn how co…

This study explores whether people with Lynch syndrome can use a self-collected vaginal swab at home to detect early signs of uterine cancer. Researchers will enroll 30 participants who will collect samples and answer surveys. The main goal is to see if this approach is practical…

Researchers in Ethiopia are studying whether tuberculosis infection changes how the placenta develops and works. They will enroll 500 pregnant women at delivery clinics and use a blood test to identify those with TB infection. The team will compare placental tissue and infant out…

This study tests whether a new type of adaptive radiotherapy can reduce radiation exposure to the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine, rectal, or cervical cancer. Using advanced imaging and an AI treatment planning system, resea…

This study aims to learn more about abnormal development of the face, head, and neck by comparing people with these conditions to their family members and healthy volunteers. Researchers will collect medical history, perform exams, take 3D images, and analyze genetic samples from…

This study follows 200 adult women who visit the gynecological emergency department for endometriosis or related symptoms. Researchers want to see if emergency care leads to proper follow-up, like specialist visits or imaging. The goal is to understand how well the emergency syst…

This study looks at women who had surgery for deep endometriosis affecting the ureters, the tubes that carry urine from the kidneys to the bladder. The goal is to see how their kidney function and blood pressure fare years after the operation, and whether the type of surgery matt…

This study is for people with cervical or pancreatic cancer who are scheduled to receive chemoradiotherapy. Researchers will collect tumor samples, blood, and imaging data before, during, and after treatment to see how the tumor environment changes over time. The goal is to learn…

This study looks at tumor samples from 2,100 Chinese patients with lung, gynecologic, bile duct, or bladder cancers. Researchers will compare different HER2 testing methods to see how well they agree with each other. The goal is to improve the accuracy of HER2 testing, which help…

This study will compare patient satisfaction between telehealth (video or phone) and in-person follow-up visits after minimally invasive gynecologic surgery. About 100 women will be randomly assigned to one of the two follow-up methods. The goal is to see if virtual visits are as…

This study looks at whether vitamin D levels in the blood and cervical fluid before treatment can predict how well chemoradiotherapy works for locally advanced cervical cancer. Researchers will measure vitamin D in 100 women undergoing standard treatment and track their response …

This study aims to understand the challenges women with endometriosis face when trying to access pelvic health physiotherapy in Quebec. Researchers will interview patients, survey physiotherapists, and hold group discussions with patients and healthcare providers. The goal is to …

This study looks at whether older adults with gynecologic cancer are willing to complete physical and cognitive tests before and after treatment. Researchers will also take small muscle and blood samples to study how cell energy relates to resilience. The goal is to see if this k…

This study is testing a computer model called ENDORISK that helps doctors predict whether endometrial cancer has spread to lymph nodes. About 735 patients with early-stage endometrial cancer will use the model to guide decisions about lymph node surgery. The goal is to see if the…

This study looks at the immune system of 120 women aged 18-40 with chronic pelvic pain that hasn't improved with hormone treatment. Researchers will measure specific immune markers in the blood to see if there is a unique pattern linked to the pain. The goal is to better understa…

This study will test a new way to screen and treat cervical cancer in women with HIV in Mozambique. About 8,445 women aged 25-49 who are already receiving HIV care will be offered HPV testing and same-day treatment if needed. The goal is to see if this approach can screen more wo…

This study looks at how deeply argon beam coagulation (a tool that uses ionized gas to seal tissue) penetrates the ovary during laparoscopic surgery for ovarian endometriomas. Researchers will apply the technique to the cyst surface before removing it, then examine the tissue und…

This study looks at how surgery for severe deep endometriosis impacts a woman's egg supply, measured by a hormone called AMH. Researchers will follow 100 women aged 18 to 39 for 12 months after surgery. The goal is to see if the procedure lowers AMH levels, which could help guide…

This study follows people who have already received gene transfer therapy for cancer or other conditions. The goal is to monitor long-term safety and any side effects over up to 15 years. No new treatment is given; participants provide health updates and occasional blood samples.…

This study looks at whether it is safe for women with endometrial cancer to fast overnight before their surgery. Many women with this cancer have high blood sugar and inflammation, which may help the cancer grow. The study will check if fasting is doable and liked by patients, an…

This study investigates why endometriosis and migraine often occur together. Researchers will measure pain sensitivity and sex hormone levels in four groups: people with endometriosis, people with migraine, people with both conditions, and healthy controls. Participants complete …

This study investigates why some advanced or recurrent endometrial cancers respond to immunotherapy while others do not. Researchers will collect tumor samples from 510 patients before they start immunotherapy and use lab-grown tumor models to study molecular and genetic features…

This study looks at the bacteria living in the mouth, stool, and tumors of Colombian adults with advanced cancers of the stomach, colon, breast, cervix, or head and neck who are starting immunotherapy as standard care. Researchers will compare these microbial profiles to those of…

This study follows thousands of very low birth-weight and premature infants to track their development over time. Researchers collect data on pregnancy, birth, and early childhood outcomes to identify factors that influence brain and body development. No treatments are tested—thi…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study is collecting live tumor samples from 2,000 cancer patients undergoing standard biopsies. Researchers will analyze these samples to understand how tumors respond to immunotherapy drugs outside the body. The goal is to develop a method to predict which patients will res…

This study is looking at 135 women with and without endometriosis to understand how hormones, environmental chemicals, and vaginal bacteria differ between the groups. Researchers hope to find patterns that could lead to faster diagnosis and better treatments. Participants give bl…

This observational registry is gathering data from 500 adults whose gynecologic cancer has returned after prior radiation therapy. Doctors are using reirradiation or other ablative strategies as part of standard care, and the registry will track how well these treatments control …

This study is looking at 180 women with advanced cervical cancer who were treated with radiation and chemotherapy. Researchers want to see if high levels of certain proteins (called IAPs) in the original tumor biopsy can predict whether the cancer will come back within two years.…

This study is observing 300 women with female sexual organs who are receiving radiotherapy for certain cancers. Researchers want to understand why some patients have more sexual side effects than others. They will track sexual quality of life and look at radiation doses to find p…

This study is looking for certain cells in the blood of people with 9 types of advanced cancers that have spread. Researchers will take one blood sample from each of 450 participants before they start a new treatment. They will use two different lab methods to see if they can fin…

This study looks at whether women with Ehlers-Danlos syndrome (EDS) experience more severe period pain than those without the condition. Researchers will compare pain levels and other gynecological issues in 156 women using an online questionnaire. The goal is to better understan…

This study aims to better understand pre-eclampsia and intrauterine growth restriction (IUGR), serious pregnancy complications affecting about 9% of pregnancies. Researchers will collect placenta, blood, and urine samples from 500 pregnant women—both with and without these condit…

This study tests an online training program designed to help primary health care workers in Brazil give better advice on physical activity and reducing sedentary time. Over 3,300 health professionals will take the self-paced course and have their counseling skills measured before…

This study follows 80 cervical cancer patients who receive brachytherapy (internal radiation) to see if they develop post-traumatic stress disorder (PTSD). Participants fill out questionnaires about PTSD, anxiety, depression, quality of life, and sexual health over 5 years. The g…

This pilot study is testing whether a 7-day integrative oncology retreat called 'Via Shalva' is practical and helpful for women who have finished primary treatment for breast or gynecologic cancer. Thirty participants will either attend the retreat or receive usual follow-up care…

This observational study is looking at 350 women with early-stage endometrial cancer to see if doctors can better predict who really needs lymph node removal during surgery. Participants receive standard care and are followed for three years. The goal is to find out if some patie…

This study looks at how pesticides and the bacteria in your gut and genital tract might be linked to endometriosis and infertility. Researchers will compare 160 women with and without endometriosis to find patterns in their DNA and bacteria. The goal is to better understand the d…

This study looks at 1,000 women undergoing IVF to understand how tiny organisms in the womb (the microbiome) may cause chronic endometritis, a condition that can harm fertility. Researchers will collect samples from the vagina and womb to compare the microbes in women with and wi…

This study listens to 150 people with endometriosis across Europe to understand how they manage their condition every day. Researchers want to learn what makes people feel empowered or abandoned by their support systems. Participants will share their stories through diaries, inte…

This study aims to validate a gene test that identifies oxygen-starved (hypoxic) tumours in bladder and prostate cancer patients. About 30 participants will provide tumour samples and blood, and some will have MRI scans. The goal is to see if this test can help doctors choose mor…

This study compares two types of uterine incisions (high vs low) during a first cesarean section to see which leads to fewer scar defects. 168 pregnant women having their first C-section will be randomly assigned to one of four groups, combining incision type with a stitching tec…

This Swiss study is testing whether creating a detailed molecular profile of each patient's tumor can help doctors choose more effective treatments for advanced ovarian cancer. Sixty newly diagnosed patients will be randomly assigned to either standard care or a personalized trea…

This trial is testing whether using a uterine manipulator during minimally invasive hysterectomy for endometrial cancer affects the chance of cancer coming back. About 1,030 women with early-stage endometrial cancer will be randomly assigned to have surgery with or without the de…

This study examines how cells in the placenta manage waste and self-destruction in women with pregnancy complications like pre-eclampsia and intrauterine growth restriction. Researchers will take blood and urine samples from 50 pregnant women throughout their pregnancy and at del…

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study aims to gather and analyze detailed medical information from 10,000 people diagnosed with endometrial cancer in Italy. Researchers will look at how the cancer's molecular and immune features affect how long patients stay free of the disease and how long they live overa…

This study surveys about 264 Italian hospitals that treat endometrial cancer to find out how often they use POLE testing. POLE testing helps doctors know which patients have a very low risk of cancer returning and may not need extra treatment. The goal is to understand current pr…

This study follows 200 women with gynecologic cancer and their partners to see how sexual function changes over time. Researchers use questionnaires at diagnosis, 6 months, and 12 months after treatment. The goal is to understand when sexual counseling might be most helpful, with…

This study looks at 300 people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer. Researchers want to understand why some patients still develop cancer even with regular check-ups. They will analyze blood, gut bacteria, and hair samples to find cl…

This study looks at whether an interactive video program, combined with help from a community health worker, can increase cervical cancer screening among African American women who are overdue for a test. About 288 women will take part, completing two phone surveys and having the…

This study will use pelvic ultrasound to check for endometriosis and adenomyosis in 400 women aged 29–37 who are freezing their eggs for non-medical reasons. Researchers will compare imaging findings with symptoms, anxiety, depression, and quality of life. The goal is to understa…

This study follows 462 women pregnant after egg donation or standard IVF to learn why pre-eclampsia is more common in egg donation pregnancies. Participants give blood samples and have regular check-ups throughout pregnancy. The goal is to find early warning signs and improve car…

This study uses a special contrast dye (SonoVue) during ultrasound to look at blood flow in the placenta of pregnant women with fetal growth restriction. The goal is to better understand how the placenta works when the baby is not growing well. Thirty women who have already decid…

This study tests whether artificial intelligence can help more women in Occitanie, France, complete cervical cancer screening. About 3,000 women aged 30-65 who haven't been screened recently will be invited to use a self-sampling kit. The goal is to see if AI-assisted decision-ma…

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study looks at whether testing for HPV DNA from a cervical swab or a blood sample can help find cervical cancer that has come back after radiotherapy. Researchers will follow 120 patients for two years after treatment, collecting samples at regular visits. The goal is to see…

This study follows 200 women aged 20-50 with adenomyosis, a condition causing pelvic pain and heavy bleeding. Researchers will observe which treatments doctors prescribe and how well they work over 12 months. The goal is to understand current medical practices and help develop be…

This study is a large registry that collects information on very low birth weight infants (weighing 401-1000 grams or born before 29 weeks) at multiple hospitals. Researchers track the babies' health, treatments, and outcomes to find patterns and improve future care. No experimen…

This study collects tissue samples from people with various advanced or early-stage cancers to train a diagnostic platform called Elephas. The goal is to see how accurately it can predict whether a patient will respond to immunotherapy or chemoimmunotherapy. About 324 participant…

This study looks at whether a special PET scan and a blood test for HPV can detect any remaining cervical cancer cells after standard chemoradiation. About 64 people with cervical cancer will be followed after their usual treatment. The goal is to see if these tests can predict i…

This early study at Duke University is testing whether combining transrectal ultrasound (TRUS) images with MRI scans can help doctors guide needles more accurately during brachytherapy for uterine cancer. The researchers will enroll 17 adults with uterine or cervical cancer who a…

This study looks at whether MRI scans can help doctors predict which women with endometriosis will benefit from the drug dienogest. Researchers will follow 48 women aged 19-45 who are starting dienogest for the first time. By comparing MRI images before treatment with changes in …

This study looks at whether using a uterine manipulator during hysterectomy changes sexual function three months after surgery. Sixty women having a hysterectomy for non-cancer reasons will be randomly assigned to have the surgery with or without the tool. The main goal is to com…

This study follows 650 women with endometriosis who want to have children after diagnosis. Researchers compare pregnancy rates and the need for fertility treatments between those who had surgery and those who took medication. The goal is to understand which approach leads to bett…

This study follows 300 women aged 18–40 with severe cervical precancer (CIN 2 or 3) to see how often these lesions regress on their own or after surgery. Researchers will track HPV and Pap test results to identify factors that predict healing. The goal is to create a model that h…

This study looks back at medical records of 350 people with cervical cancer that has come back or spread to a few spots. The goal is to see how well treatments like radiation or surgery work, alone or with chemotherapy. Researchers want to find out which patients benefit most fro…

This study looks at 1,000 women to see how ultrasound features of adenomyosis (a condition where the uterine lining grows into the muscle wall) match up with their symptoms like pain and heavy bleeding. Participants get one routine ultrasound and fill out a symptom questionnaire.…

This study is creating a registry to collect information from hospitals across Asia on how brachytherapy (internal radiation) is used to treat cervical cancer. The goal is to understand current practices, track outcomes, and find ways to improve care for women with this disease. …

This study looks at better ways to provide cervical cancer screening and treatment to women living with HIV in Nigeria. About 2,400 women will take part. Researchers will compare two sets of strategies to see which works best for getting women screened and treated. The goal is to…

This study aims to see if a newer type of scan, called PET/MRI, is better than the standard PET/CT scan at finding cancer spread in lymph nodes for people with cervical cancer. About 50 adults with stage IB2 to IVA cervical cancer will be enrolled. Researchers will compare the ac…

This study looks at how the dose and storage conditions of a dye called indocyanine green (ICG) affect its ability to find sentinel lymph nodes during surgery for cervical, endometrial, and vulvar cancers. Researchers will enroll 30 patients to see which approach works best and s…

This study looks at how pelvic radiation therapy changes the immune system in people with cervical cancer. Researchers want to understand if radiation helps or hurts the body's ability to fight cancer long-term. About 110 participants will provide blood and tumor samples before, …

This study looks at whether hospitals in India are following standard guidelines for treating cervical cancer with radiation and chemotherapy. Researchers will review records from over 600 patients treated at multiple centers to see how often the recommended care is given. The go…

This study collects tumor and blood samples from over 1,000 people with certain cancers (ovarian, breast, head and neck, cervical, vulva, and sarcoma). Researchers will analyze the samples to find links between genetic changes, the immune system, and how the cancer behaves. Parti…

This study aims to create a complex lab-grown model of endometrial tissue using biopsies from women with and without endometriosis. Researchers will test how different hormone treatments affect the tissue, with the goal of predicting individual responses. The study involves 90 wo…

This study is a large German registry that will follow nearly 2,000 people with advanced ovarian or endometrial cancer. Researchers will collect information on the treatments patients actually receive, how their disease responds, and their quality of life. The goal is to understa…

This study tests whether a new smartphone app called elleFA can help women with endometriosis track their symptoms and communicate better with their doctors. Twenty pre-menopausal women aged 18 and older will use the app for 6 months, completing monthly surveys and optional daily…

This study collects blood and leftover tissue samples from 9,600 people with various cancers, including breast, lung, and pancreatic cancer. Researchers will use these samples to improve tests that look for cancer DNA in the blood. The goal is to better detect if cancer returns o…

This study is testing whether artificial intelligence can help doctors better classify and predict the behavior of rare smooth muscle tumors of the uterus, including those that are hard to diagnose (called STUMP). Researchers will train AI models on digital images of tumor tissue…

This study tests a program called DADA-LINK to help more women in Kenya get screened for cervical cancer. The program includes HPV self-sampling kits, a care navigator to guide patients, and a phone app to track care. About 1,980 women aged 25-49 will take part, and researchers w…

This study looks at whether a special hospital visit with a team of experts can help women who finished treatment for ovarian or endometrial cancer get more of the supportive care they need. About 268 women in remission will be split into groups: some get the extra hospital asses…

This study looks at MRI scans from 120 women with advanced cervical cancer to see if a computer model can predict how well their tumors respond to standard chemotherapy and radiation. The goal is to identify women who might need different or stronger treatments early on. Research…

This study follows 100 people with a rare type of uterine tumor called endometrial stromal tumor. Researchers collect information on how the disease progresses and how it is diagnosed. No new treatments are tested; the goal is simply to learn more about the condition.

This study from the University of Oxford is looking at whether brain scans can predict which women with severe endometriosis will have less pain after surgery. Researchers will scan the brains of 100 women before their operation and then check their pain levels a year later. The …

This study looks at how well pelvic organs move in women with endometriosis using dynamic MRI. Researchers want to see if measuring this movement can help diagnose the disease better and explain why some treatments don't work. About 52 women with suspected endometriosis will take…

The CONEXUS study is testing a new type of brain imaging called functional ultrasound (fUS) in 76 newborns at high risk for neurodevelopmental disorders. The technique uses sound waves to measure blood flow changes in the brain, similar to a regular ultrasound but more advanced. …

This study looks at DNA methylation patterns in brain, thyroid, and endometrial tumors. Researchers aim to better classify these cancers and find new markers for early diagnosis. The study will involve 180 participants and uses existing tumor samples.

This study is gathering information from 640 pregnant people to build a computer model that can predict placental insufficiency — a condition where the placenta doesn't work well and can lead to stillbirth. Participants will have extra ultrasounds and blood tests during pregnancy…

This study at Johns Hopkins University is looking at how aging cells (senescent cells) contribute to uterine fibroids, which are non-cancerous growths in the uterus. Researchers will analyze tissue samples from 150 women with fibroids to map these cells and their signals. The goa…

This study aims to learn how gene and protein changes in gynecologic tumors affect cancer behavior and treatment response. Researchers will collect tumor tissue and blood samples from 1,000 people with ovarian, uterine, cervical, or other gynecologic cancers. The goal is to bette…

This study follows 6,000 pregnant women in rural Pakistan to understand how high temperatures impact pregnancy and birth outcomes. Researchers will track heat exposure, collect blood and urine samples, and monitor mothers and babies for up to a year after birth. The goal is to id…

This study is testing whether tumor tissue from endometrial cancer patients can be successfully turned into organoids (tiny lab-grown models) after being transported from other hospitals. About 20 adults with endometrial cancer will provide a sample during their standard surgery.…

This study is building a national registry to collect data on people with parietal endometriosis, a condition where endometriosis tissue grows in the abdominal wall. Researchers will track those treated with either surgery or a less invasive technique called cryoablation (freezin…

This study aims to create a large collection of blood samples from 2,500 people with or at high risk for cancer. Researchers will use these samples to study liquid biopsies, which are blood tests that may help detect cancer, track treatment response, and spot recurrence. Particip…

This study looks at whether a simple, non-invasive eye scan can detect signs of inflammation in women with endometriosis. Researchers will compare retinal images from 100 women—half with endometriosis and half without—to see if the eyes can reveal information about this condition…

This study takes small tissue samples from 24 women with cervical cancer and grows them into mini tumors called organoids. These organoids act like avatars to test which drugs work best, aiming to avoid unnecessary radiation and its side effects. The goal is to learn more about t…

This study follows 15,000 women with endometriosis for up to 10 years to see how well different medical and surgical treatments work. Researchers will track symptoms, quality of life, disease return, and pregnancy rates. The goal is to better understand the long-term outcomes of …

This study is looking at 60 women who are getting a hormone-releasing IUD (LNG-IUD) to see if the timing of insertion during their menstrual cycle affects whether they develop ovarian cysts. Researchers will use ultrasound to check for cysts at 0, 3, 6, and 12 months after insert…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study follows 5,300 women aged 18-42 with endometriosis or adenomyosis to see if these conditions get worse over time. Researchers track pain, bleeding, fertility, and use imaging to monitor changes. They also explore immune system and gut bacteria links. No new treatment is…

This study looks at whether chlordecone, a pesticide still present in the environment in Guadeloupe, is linked to fertility problems in women. Researchers will measure a key fertility hormone (AMH) and count egg follicles in 634 women seeking fertility treatment. The goal is to u…

This study compares two approaches after robotic hysterectomy: going home the same day versus staying overnight in the hospital. Researchers will track quality of life and complications over 30 days in 300 patients with benign conditions or endometrial cancer. The goal is to see …

This study is looking at whether using a device called a uterine manipulator during minimally invasive surgery for early stage endometrial cancer causes cancer cells to spread into the abdominal fluid. About 278 women will be randomly assigned to have surgery with or without the …

This study tests a surgical tool called CUSA Clarity that uses ultrasound to selectively remove endometriosis cyst lining while leaving healthy ovary tissue intact. Researchers will examine cyst wall samples from 10 women to see if the tool can spare ovarian tissue, which may hel…

This observational study is recruiting 530 women to better understand endometriosis and adenomyosis. Researchers will analyze genetic, epigenetic, and imaging data, using artificial intelligence to develop better diagnostic tools. The goal is to enable earlier detection and more …

This study follows 1,489 women diagnosed with hydatidiform mole (molar pregnancy) across multiple hospitals in China. Researchers will track how often the condition becomes cancerous and look for ways to predict and prevent that. The goal is to create a nationwide system for bett…

This study tests whether pregnant women with complications like pre-eclampsia or fetal growth restriction can use a remote device at home to monitor their baby's heart rate. Sixty participants between 32 and 37 weeks of pregnancy will try the device daily. Researchers will check …

This study will collect blood and tumor samples from 1,100 people with various cancers, including head and neck, ovarian, cervical, lung, and brain cancers. Researchers want to learn how immune cells called T cells behave in these tumors. The goal is to better understand why some…

This study collects amniotic fluid from 275 pregnant women delivering at various stages, including extremely preterm. Researchers will analyze the fluid's microbes and chemicals, and link them to the baby's gut bacteria and health outcomes like necrotizing enterocolitis (NEC) and…