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Could vitamin d predict cervical cancer treatment success?

NCT ID NCT07743918

Knowledge-focused Sponsor: University of Kragujevac Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study looks at whether vitamin D levels in the blood and cervical fluid before treatment can predict how well chemoradiotherapy works for locally advanced cervical cancer. Researchers will measure vitamin D in 100 women undergoing standard treatment and track their response and side effects. The goal is to see if vitamin D could serve as a biomarker to guide treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pretreatment vitamin D assessment in serum and cervical lavage fluid
What this could lead to
If vitamin D levels predict treatment response, this could lead to a simple test to guide therapy and improve outcomes for cervical cancer patients.
What could go wrong
This is an observational study, so it cannot prove cause and effect. Results may not apply to all patients, and vitamin D levels could be influenced by many factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Sep 2034

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will include adult individuals who self-identify as female, aged 18 to 80 years, with histopathologically confirmed locally advanced cervical cancer, FIGO 2018 stage IIB-IVA, who are planned for definitive concurrent chemoradiotherapy at the Clinic for Radiation Oncology, University Clinical Center Kragujevac. All participants must provide written informed consent and be eligible for standard treatment consisting of external beam radiotherapy, high-dose-rate brachytherapy, and weekly cisplatin-based chemotherapy.

Ages

18 to 80 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female patients aged 18 to 80 years. * Histopathologically confirmed cervical cancer. * Locally advanced disease, FIGO 2018 stage IIB to IVA. * Eastern Cooperative Oncology Group performance status 0-1. * Planned treatment with definitive concurrent chemoradiotherapy. * Signed informed consent. * Ability to comply with study procedures and follow-up visits. Exclusion Criteria: * Age under 18 years. * Pregnancy or lactation. * Previous or synchronous diagnosis of another pelvic or abdominal malignancy. * Previous chemotherapy. * Previous radiotherapy. * Previous treatment with immune checkpoint inhibitors. * Current or recent vitamin D supplementation. * Interrupted oncological treatment. * Failure to attend scheduled follow-up visits. * Incomplete medical documentation.

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Conditions

The condition(s) this trial relates to.

cervical cancer radiation injury vitamin D deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Locally advanced cervical cancer Vitamin D concentration

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Clinical Center Kragujevac

    RECRUITING

    Kragujevac, Šumadija, 34000, Serbia

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