New study tests better embryo transfer prep for women with adenomyosis
NCT ID NCT06239376
First seen Mar 27, 2026 · Last updated Jun 22, 2026 · Updated 10 times
Summary
This study tests whether a two-month hormone pretreatment (GnRH agonist plus letrozole) before standard frozen embryo transfer preparation leads to more live births than standard preparation alone in women with adenomyosis. About 222 women aged 18-42 will be randomly assigned to one of the two groups. The goal is to find a more effective way to help these women have a baby.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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My Duc Hospital
RECRUITINGHo Chi Minh City, Ho Chi Minh City, 70000, Vietnam
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
GnRH agonist (Diphereline) and letrozole (Femara) followed by estradiol valerate and progesterone
What this could lead to
If successful, this could identify a better way to prepare the uterus for embryo transfer in women with adenomyosis, potentially increasing the chance of a live birth.
What could go wrong
This is a relatively small, early-phase trial (222 participants) comparing two existing protocols, so results may not be definitive or widely applicable. Side effects from the hormone treatments are possible.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.