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New study tests Uterus-Saving approach for dangerous pregnancy condition

NCT ID NCT06512181

Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests a conservative management strategy for placenta accreta, a serious pregnancy complication where the placenta grows too deeply into the uterine wall. Instead of the standard treatment—a hysterectomy (removing the uterus) after a C-section—doctors will leave the placenta in place and monitor the patient closely. The goal is to see if this approach can safely preserve the uterus in 15 women who want to avoid hysterectomy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Conservative management (leaving the placenta in place after delivery)
What this could lead to
If successful, this approach could offer a safer alternative to hysterectomy for some women with placenta accreta, allowing them to keep their uterus.
What could go wrong
This is a very small pilot study (15 people) with no comparison group. The approach may still lead to serious complications like infection or bleeding, and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Provision of signed and dated informed consent form. 2. Stated willingness to comply with all study procedures and availability for the duration of the study. 3. A person with a uterus, age 18 or older 4. Currently pregnant with an intrauterine gestation or postpartum 5. Suspected of having PAS based on history, clinical findings, and/or imaging 6. Patients for whom the usual management would be peripartum hysterectomy. 7. Patient desires uterine preservation or declines hysterectomy 8. Agreement to adhere to Lifestyle Considerations (see section 5.3) throughout study duration. Exclusion Criteria: • Have a low antenatal suspicion for PAS based on imaging.

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Conditions

The condition(s) this trial relates to.

placenta accreta

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Placenta accreta spectrum

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital of the University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

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