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Could immune clues unlock endometriosis mysteries?

NCT ID NCT07078435

Knowledge-focused Sponsor: University Hospital, Grenoble Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study will compare immune cells and gut bacteria in 40 women with and without endometriosis. Researchers will take tissue and blood samples during surgery and collect stool samples over a year. The goal is to find biological markers that could lead to better treatments for this painful condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could identify immune or microbiome markers that lead to new, non-hormonal treatments for endometriosis.
What could go wrong
This is an early, small observational study (40 participants) that aims to understand the disease, not test a treatment. It may not lead to any new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2025

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 42 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women aged 18-42 years. * Surgery scheduled during the luteal phase. * Written informed consent provided. Additional inclusion criteria for the "endometriosis" group: * Women with confirmed endometriosis and a surgical indication (due to persistent symptoms despite medical treatment and/or risk of organ damage). * Hormonal therapy discontinued at least one month prior to surgery. * Absence of isolated ovarian endometrioma. Control group inclusion criteria: \- Women requiring benign gynecological surgery with no clinical or intraoperative evidence of endometriosis. No inclusion criteria (both groups): * Presence of inflammatory bowel disease (Crohn's disease, ulcerative colitis) or other autoimmune disorders (e.g., lupus, Sjögren's syndrome, antiphospholipid syndrome, rheumatoid arthritis, spondyloarthritis), * Use of antibiotics within the month prior to surgery, * Recent infection (\<2 weeks), * Ongoing treatment with biologics or immunosuppressants, * Contraindication to surgery due to general condition or comorbidities, * Hormonal therapy within the month prior to surgery, * Abdominopelvic surgery involving peritoneal breach within the previous 6 months, * Pregnancy or breastfeeding, * Participation in another clinical study (RIPH 1 or 2). Exclusion Criteria: * Intraoperative impossibility to perform surgery due to local conditions with an unfavorable benefit-risk balance for the patient. * Discovery of endometriosis during surgery in the control group. * Use of biologics or immunosuppressants within the first year after inclusion in the endometriosis group. * Antibiotic use in the month preceding the second stool sample (endometriosis group).

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Conditions

The condition(s) this trial relates to.

endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometriosis Immunity Microbiota

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHUGA

    Grenoble, Isère, 38000, France

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