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Can getting kids moving sooner in the ICU shorten their time on a ventilator?

NCT ID NCT04989790

Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 25, 2026 · Updated 3 times

Summary

This study tests a program called PICU Up! that helps critically ill children start moving earlier while in the pediatric intensive care unit. The program includes daily activity plans, better sedation management, and family involvement. Researchers want to see if this approach reduces how long children need a breathing machine and improves their overall recovery. The trial will involve 1,440 children across 10 U.S. hospitals.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
PICU Up! early mobility program
What this could lead to
If effective, this program could become a new standard of care to help critically ill children recover faster and with fewer complications.
What could go wrong
This is a pragmatic trial testing a complex intervention across many hospitals, so results may vary. The study is not designed to prove a cure, only to improve recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,440 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2022

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Up to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Invasive mechanical ventilation via oral or nasal endotracheal tube ≥ 48 hours at 7 a.m. on PICU Day 3 Exclusion Criteria: * Active or anticipated withdrawal of life support within 48 hours * Open chest or open abdomen * Current use of Extracorporeal Membrane Oxygenation (ECMO)

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Conditions

The condition(s) this trial relates to.

Critical Illness critical illness polyneuropathy decubitus ulcer delirium postintensive care syndrome primary interstitial lung disease specific to childhood

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Child Critical illness Hospital acquired pressure ulcer Intensive care unit-acquired weakness

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    10 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Children's Hospital at Dartmouth: Geisel School of Medicine

    RECRUITING

    Lebanon, New Hampshire, 03756, United States

  • Children's Hospital of Wisconsin: Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Hennepin Healthcare: University of Minnesota

    RECRUITING

    Minneapolis, Minnesota, 55415, United States

  • Janet Weis Children's Hospital: Geisinger Commonwealth School of Medicine

    RECRUITING

    Danville, Pennsylvania, 17822, United States

  • Johns Hopkins Hospital

    ACTIVE_NOT_RECRUITING

    Baltimore, Maryland, 21287, United States

  • Nemours Children's Hospital of the Nemours Foundation

    RECRUITING

    Orlando, Florida, 32827, United States

  • Norton Children's Hospital: University of Louisville

    RECRUITING

    Louisville, Kentucky, 40202, United States

  • Texas Children's Hospital: Baylor College of Medicine

    RECRUITING

    Houston, Texas, 77030, United States

  • UNC Children's: University of North Carolina

    RECRUITING

    Chapel Hill, North Carolina, 27514, United States

  • Valley Children's Hospital

    RECRUITING

    Madera, California, 93636, United States

  • West Virginia University Medicine Children's: West Virginia University

    RECRUITING

    Morgantown, West Virginia, 26506, United States

More trials for these conditions

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