Brain zapping study probes Cerebellum's role in thinking
NCT ID NCT06108336
First seen Jun 24, 2026 · Last updated Sep 15, 2026 · Updated 5 times
Summary
This study uses transcranial magnetic stimulation (TMS) to temporarily influence the cerebellum while healthy adults perform tasks that require sequencing or memory. By comparing brain scans with and without stimulation, researchers hope to understand how the cerebellum contributes to cognitive functions. The study involves 50 right-handed adults aged 18-50.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Transcranial magnetic stimulation (TMS)
- What this could lead to
- If successful, this could clarify how the cerebellum supports thinking and sequencing, potentially guiding future therapies for cognitive disorders.
- What could go wrong
- This is a small, early-stage study in healthy volunteers, not a treatment trial. Results may not apply to people with brain disorders.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2024
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 1\) Age 18-50; * 2\) educational attainment of at least 8 years; * 3\) capable of giving informed consent; * 4\) fluent speaker of English by self-report; * 5\) right handed. Exclusion Criteria: * 1\) illicit drug use within 30 days of MRI scanning; * 2\) neurological or systemic disorder which can cause dementia or cognitive dysfunction; * 3\) history of an Axis I psychiatric disorder including substance use disorder; * 4\) history of definite stroke; * 5\) focal lesion on MRI exam; * 6\) uncorrected visual deficits by self-report * 7\) contraindications for MRI scanning * 8\) use of anxiolytic, antidepressant, neuroleptic, or sedative medication * 9\) Additional exclusion criteria recommended by Wassermann for TMS neuromodulation, including: History of seizure or a family history of epilepsy, heart disease, intracardiac lines, increased intracranial pressure, history of head trauma, and history of respiratory disease
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Johns Hopkins University School of Medicine
RECRUITINGBaltimore, Maryland, 21205, United States