ALCOHOL USE DISORDER

This study tested whether the diabetes medication semaglutide (Rybelsus) can help people with alcohol use disorder reduce their drinking. Fifty adults who wanted to cut down or stop drinking were randomly assigned to take semaglutide or a placebo for 8 weeks. Researchers measured…

This study looked at whether a broccoli sprout extract supplement could help repair the gut lining and lower inflammation in 40 older adults (age 50+) who drink at least 8 alcoholic drinks per week and have poor diets. The goal was to see if this natural supplement could reduce h…

This study tested two smartphone apps to help people cut down on risky drinking and improve family relationships during the COVID-19 pandemic. 398 pairs of drinkers and their family members participated. One app focused on the drinker, the other involved the family. The goal was …

This study tested a non-invasive brain stimulation technique called TMS to see if it could help people with alcohol use disorder reduce their drinking. 147 adults who wanted to cut back on alcohol received TMS and were tracked for 4 months. The goal was to find out which TMS meth…

This study tested a new drug called DCR-AUD in 16 healthy adults who are social drinkers. The main goal was to see if repeat doses are safe and how the drug works in the body. Participants received either the drug or a placebo and had up to 10 alcohol interaction tests. The resul…

This study tested a smartphone-based program that combines cognitive-behavioral therapy (CBT) with medication (naltrexone) to help adults with moderate to severe alcohol use disorder reduce their drinking. About 242 employed adults with health insurance participated, and the prog…

This study tested a medication called GET73 in 79 adults with moderate to severe alcohol use disorder who were not seeking treatment. Participants took GET73 or a placebo for 8 days and had MRI scans to measure brain chemistry and activity. The goal was to see if GET73 could redu…

This study tested whether kudzu, an herbal supplement, can help people who binge drink reduce their alcohol use and risky sexual behaviors. 120 adults who reported heavy drinking and were at high risk for HIV took part. The goal was to see if kudzu could lower the number of binge…

This study tested a smartphone app and special debit card program to help 236 adults with alcohol use disorder reduce or stop drinking. Participants used breathalyzer tests and received coaching and rewards for staying sober. The goal was to see if this technology-based approach …

This study tested whether a single high dose of psilocybin, given with psychological support, could help people with alcohol use disorder drink less. Sixty adults from Denmark took part. The main goal was to see if the treatment reduced the number of heavy drinking days over the …

This study tested a technique called Episodic Future Thinking (EFT), where people imagine positive future events in detail, to see if it helps those with alcohol use disorder drink less. 154 adults who wanted to cut down on drinking participated. The approach aims to reduce impul…

This study tested a 4-week virtual intensive outpatient program for people with moderate to severe alcohol use disorder. 63 participants joined from home, using daily breathalyzer checks and online group therapy. The goal was to see if people would stay in the program and find it…

This study looked at two simple tests (MoCA and BEARNI) to see which one is better at finding thinking and memory problems in people with alcohol use disorder. Researchers tested 90 patients and compared the results to a full set of detailed brain tests. The goal was to find out …

This study tested a smartphone app designed to help people with alcohol dependence avoid relapse after leaving inpatient rehab. The app uses a game-like training to reduce unconscious cravings for alcohol. 600 participants used the app at home, and researchers tracked relapse rat…

This study tested two types of therapy for insomnia in 134 people who were also being treated for alcohol use disorder. The goal was to see if improving sleep could also help reduce drinking. Participants received either a standard insomnia treatment or a therapy that also focuse…

This study tested a mobile app called WisePath designed to help adults struggling with suicidal thoughts and alcohol misuse. 127 participants used either WisePath or a control app for 12 weeks. The goal was to see if the app could reduce suicidal thoughts and drinking while peopl…

This study tested whether an online insomnia treatment could help heavy drinkers reduce their alcohol use. 113 adults who had trouble sleeping and drank heavily took part. The program taught them skills to improve sleep, and researchers tracked changes in drinking and sleep quali…

This study tested whether cytisine, a plant-based medication, is safe and helpful for quitting smoking in people who also have alcohol use disorder. Twenty adults who smoked daily and wanted to quit took cytisine and were monitored for side effects and smoking abstinence. The goa…

This study tested a short, 11-session therapy program for adults in residential rehab for drug or alcohol problems. The therapy combined techniques to improve emotion regulation, distress tolerance, and psychological flexibility. 36 participants were split into two groups: one re…

This study looked at whether a bacterial substance called endotoxin increases drinking in people with alcohol use disorder. 27 adults took part in a lab session where they could drink alcohol after receiving either endotoxin or a placebo. The goal was to see if endotoxin changes …

This study looked at what happens when people drink alcohol and use high-THC cannabis concentrates together. 146 regular drinkers and cannabis users took part in a mobile lab session. Researchers measured things like blood alcohol level, heart rate, and cognitive performance to s…

This study tested whether an 8-week cognitive training program delivered via telehealth is practical and well-liked by veterans recovering from alcohol use disorder who have mild memory or thinking problems. Nineteen veterans participated, and the main goal was to see if they wou…

This study tested whether a gentle brain stimulation technique called tDCS, combined with cognitive training, could improve thinking skills and reduce relapse in veterans with alcohol use disorder. Forty-five veterans participated, receiving either real or sham stimulation while …

This study looked at 34 people who came to the emergency department with alcohol intoxication. Researchers asked them to guess their blood alcohol concentration (BAC) and then compared it to a real measurement. The goal was to see if showing patients the difference could help the…

This study looked at how alcohol changes brain activity and feelings in 60 young adults (21–26 years old) — half with bipolar disorder and half without. Participants received both alcohol and a placebo during brain scans to compare their reactions. The goal was to understand why …

This study looked at whether community health workers visiting pregnant women at home could improve health for both mothers and children in a rural area of South Africa. About 1,490 women took part, with some receiving home visits and others not. The program aimed to support heal…